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Age at the first psychotic episode and an interval between the onset of
epilepsy and that of psychosis reflect developmental processes of
interictal psychosis. However, factors relating to these indices remain
To identify clinical variables that are associated with the timing of the
development of interictal psychosis.
In 285 adults with epilepsy with interictal psychosis, effects of
epileptic (epilepsy type), organic (intellectual functioning) and genetic
(family history of psychosis) variables on timing of the development of
psychosis were examined.
The mean interval between the onset of epilepsy and that of psychosis was
14.4 years. Some psychosis occurred within a few years of the first
seizure. Generalised epilepsy, normal intellectual function and a
positive family history of psychosis were associated with early onset of
Early development of interictal psychosis in people with epilepsy may
reflect other individual vulnerabilities to psychosis rather than
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