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Oral rotavirus vaccine efficacy estimates from randomised controlled trials are highly variable across settings. Although the randomised study design increases the likelihood of internal validity of findings, results from trials may not always apply outside the context of the study due to differences between trial participants and the target population. Here, we used a weight-based method to transport results from a monovalent rotavirus vaccine clinical trial conducted in Malawi between 2005 and 2008 to a target population of all trial-eligible children in Malawi, represented by data from the 2015–2016 Malawi Demographic and Health Survey (DHS). We reweighted trial participants to reflect the population characteristics described by the Malawi DHS. Vaccine efficacy was estimated for 1008 trial participants after applying these weights such that they represented trial-eligible children in Malawi. We also conducted subgroup analyses to examine the heterogeneous treatment effects by stunting and tuberculosis vaccination status at enrolment. In the original trial, the estimates of one-year vaccine efficacy against severe rotavirus gastroenteritis and any-severity rotavirus gastroenteritis in Malawi were 49.2% (95% CI 15.6%–70.3%) and 32.1% (95% CI 2.5%–53.1%), respectively. After weighting trial participants to represent all trial-eligible children in Malawi, vaccine efficacy increased to 62.2% (95% CI 35.5%–79.0%) against severe rotavirus gastroenteritis and 38.9% (95% CI 11.4%–58.5%) against any-severity rotavirus gastroenteritis. Rotavirus vaccine efficacy may differ between trial participants and target populations when these two populations differ. Differences in tuberculosis vaccination status between the trial sample and DHS population contributed to varying trial and target population vaccine efficacy estimates.
Impactful, transdisciplinary scientific discoveries are created by teams of researchers spanning multiple disciplines, but collaboration across disciplines can be challenging. We examined how team dynamics and collaboration are related to successes and barriers faced by teams of researchers from multiple disciplines.
Methods:
A mixed-methods approach was used to examine 12 research teams granted multidisciplinary pilot awards. Team members were surveyed to assess their team dynamics and individual views about transdisciplinary research. Forty-seven researchers (59.5%) responded, including two to eight members from each funded team. Associations were examined between collaborative dynamics and scholarly product outcomes, including manuscripts, grant proposals, and awarded grants. One member from each team was selected for an in-depth interview to contextualize and extend information about collaborative processes, successes, and barriers to performing transdisciplinary research.
Results:
Quality of team interactions was positively associated with achievement of scholarly products (r = 0.64, p = 0.02). Satisfaction with team members (r = 0.38) and team collaboration scores (r = 0.43) also demonstrated positive associations with achievement of scholarly products, but these were not statistically significant. Qualitative results support these findings and add further insight into aspects of the collaborative process that were particularly important to foster success on multidisciplinary teams. Beyond scholarly metrics, additional successes from the multidisciplinary teams were identified through the qualitative portion of the study including career development and acceleration for early career researchers.
Conclusions:
Both the quantitative and qualitative study results indicate that effective collaboration is critical to multidisciplinary research team success. Development and/or promotion of team science-based trainings for researchers would promote these collaborative skills.
LiDAR coverage of a large contiguous area within the Mirador-Calakmul Karst Basin (MCKB) of northern Guatemala has identified a concentration of Preclassic Maya sites (ca. 1000 b.c.–a.d. 150) connected by causeways, forming a web of implied social, political, and economic interactions. This article is an introduction to one of the largest, contiguous, regional LiDAR studies published to date in the Maya Lowlands. More than 775 ancient Maya settlements are identified within the MCKB, and 189 more in the surrounding karstic ridge, which we condensed into 417 ancient cities, towns, and villages of at least six preliminary tiers based on surface area, volumetrics, and architectural configurations. Many tiered sites date to the Middle and Late Preclassic periods, as determined by archaeological testing, and volumetrics of contemporaneously constructed and/or occupied architecture with similar morphological characteristics. Monumental architecture, consistent architectural formats, specific site boundaries, water management/collection facilities, and 177 km of elevated Preclassic causeways suggest labor investments that defy organizational capabilities of lesser polities and potentially portray the strategies of governance in the Preclassic period. Settlement distributions, architectural continuities, chronological contemporaneity, and volumetric considerations of sites provide evidence for early centralized administrative and socio-economic strategies within a defined geographical region.
Starting from the biblical depiction of Christ’s incarnate personhood, this chapter traces the early church’s discernment of the deity and humanity of Christ that culminated in the Chalcedonian definition. Exploring the range of christological options, the chapter emphasizes the promise of a kenotic christology for making sense of Chalcedon’s intentions and parameters, including a fuller appreciation of Christ’s humanity.
This chapter articulates the identity of the church by way of key biblical metaphors and the Nicene Creed. It then examines the church’s mission, the role of proclamation and the sacraments, and the missional shape of the doctrine of election.
This chapter considers the meaning of the claim that human beings are created in God’s image (imago Dei), offering a representational-relational conception of the doctrine. It also examines how the corruptive effects of sin deface humanity’s image-bearing, pointing to the need for the image to be restored through the person of Jesus Christ, the true image of God.
This chapter takes up the doctrine of God generally, concentrating on the traditional understanding of divine being as a complex of attributes derived via positiva and via negative (i.e., “classical theism”). Given classical theism’s tensions with the biblical narrative, as well as its role in helping to foster the rise of modern atheism, the chapter argues for a rigorous trinitarian rethinking of key traditional divine attributes.
This chapter looks at the reality of religious plurality – more particularly, the relationship between the Christian church and other religious traditions – including the common typology of exclusivism, inclusivism, and pluralism. It also explores the significance of the fact that the Christian church’s numerical center has shifted from the West to the South and East, with significant consequences for the mission and theology of the church.
This chapter explores how the life, death, and resurrection of Jesus Christ make reconciliation possible. It surveys the diverse biblical motifs surrounding reconciliation/atonement, the variety of traditional “atonement theories” that flowed out of those motifs, and a way of coherently integrating a variety of atonement approaches.
This chapter analyzes the context and theology of the Protestant Reformation, focusing on key theologians such as Luther, Melanchthon, Zwingli, and Calvin. It also examines responses to the Protestant Reformation, such as the radical reformers and forms of Catholic reformation, concluding with an exploration of the connection between Reformation theology and the rise of Protestant orthodoxy, pietism, and new forms of rationalism.
This chapter elaborates four pillars of an “ecumenical eschatology”: (1) the second coming of Christ (vis-à-vis “going to” heaven); (2) resurrection of the body (vis-à-vis an exclusive emphasis on an immortal soul); (3) final judgment/justice that is historical and public (vis-à-vis one that is heavenly and private); and (4) new heaven and earth (vis-à-vis an exclusive emphasis on heaven). It contends for a creational understanding of this doctrine, which implies that eschatology, rather than being merely a theological afterthought, is a central and mobilizing theme.
This chapter charts the medieval consolidation of the Christian world’s inheritance from the patristic tradition, giving some attention to the Byzantine East but primarily focusing on western theology. It examines important theological debates of the early Middle Ages, describes the development of scholastic theology, and explores the theology produced by the mendicant orders, especially that of Thomas Aquinas.
This chapter explores the contextual situation of theology today, engaging the set of challenges inherent in being caught between modernity (with challenges such as secularization, atheism, dehumanization, suffering, and the ecological crisis) and so-called postmodernity (with issues such as the demise of truth, the crisis of meaning, and a deepened global consciousness).
Beginning with a discussion of the difficult matter of defining “salvation,” this chapter explores the creational scope of the doctrine, which requires moving beyond a merely individualistic consideration of salvation. Within this context, the chapter addresses the traditional soteriological topics: justification, sanctification, the shape of the Christian life, and the eschatological orientation of salvation, including the resurrection of the body.
This chapter explores the nature, purpose, and method of Christian theology, giving attention to the classic Augustinian/Anselmian conception of theology as “faith seeking understanding.” It describes Christian theology as a systematic web of themes, the articulation of which aims at biblical-confessional soundness, logical coherence, and practical relevance.
This chapter surveys Christian theology from the turbulent 1960s – including significant reforms in Catholic theology, a renewed emphasis on history and eschatology in Protestant theology, and the rise of political and liberation theologies – to the postmodern present. The chapter concludes the book by inquiring about the significance of non-western theological proposals for the increasingly secularized West.