We evaluated whether universal chlorhexidine bathing (decolonization) with or without COVID-19 intensive training impacted COVID-19 rates in 63 nursing homes (NHs) during the 2020–2021 Fall/Winter surge. Decolonization was associated with a 43% lesser rise in staff case-rates (P < .001) and a 52% lesser rise in resident case-rates (P < .001) versus control.

Stem cells give rise to the entirety of cells within an organ. Maintaining stem cell identity and coordinately regulating stem cell divisions is crucial for proper development. In plants, mobile proteins, such as WUSCHEL-RELATED HOMEOBOX 5 (WOX5) and SHORTROOT (SHR), regulate divisions in the root stem cell niche. However, how these proteins coordinately function to establish systemic behaviour is not well understood. We propose a non-cell autonomous role for WOX5 in the cortex endodermis initial (CEI) and identify a regulator, ANGUSTIFOLIA (AN3)/GRF-INTERACTING FACTOR 1, that coordinates CEI divisions. Here, we show with a multi-scale hybrid model integrating ordinary differential equations (ODEs) and agent-based modeling that quiescent center (QC) and CEI divisions have different dynamics. Specifically, by combining continuous models to describe regulatory networks and agent-based rules, we model systemic behaviour, which led us to predict cell-type-specific expression dynamics of SHR, SCARECROW, WOX5, AN3 and CYCLIND6;1, and experimentally validate CEI cell divisions. Conclusively, our results show an interdependency between CEI and QC divisions.

The dynamics of the subgrid-scale (SGS) stress and scalar flux in the convective atmospheric surface layer are studied through the budgets of the SGS turbulence kinetic energy (TKE), the SGS stress and the SGS temperature flux using field measurements from the Advection Horizontal Array Turbulence Study (AHATS). The array technique, which employs sensor arrays to perform filter operations to obtain the SGS velocity and temperature, is extended to include pressure sensors to measure the fluctuating pressure, enabling separation of the resolvable- and subgrid-scale pressure, and therefore for the first time allowing for measurement of the pressure covariance terms and the full SGS budgets. The non-dimensional forms of the SGS budget terms are obtained as functions of the stability parameter $z/ L$ and the ratio of the wavelength of the spectral peak of the vertical velocity to the filter width, ${\Lambda }_{w} / {\Delta }_{f} $. The results show that the SGS TKE budget is a balance among the production, transport and dissipation. The SGS shear stress budget and the SGS temperature flux budgets are dominated by the production and pressure destruction, with the latter causing return to isotropy. The budgets of the SGS normal stress components are more complex. Most notably the pressure–strain-rate correlation includes two competing processes, return to isotropy and generation of anisotropy, the latter due to ground blockage of the large convective eddies. For neutral surface layers, return to isotropy dominates. For unstable surface layers return to isotropy dominates for small filter widths, whereas for large filter widths the ground blockage effect dominates, resulting in strong anisotropy. The results in the present study, particularly for the pressure–strain-rate correlation, have strong implications for modelling the SGS stress and flux using their transport equations in the convective atmospheric boundary layer.