To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Cardiac involvement associated with multi-system inflammatory syndrome in children has been extensively reported, but the prevalence of cardiac involvement in children with SARS-CoV-2 infection in the absence of inflammatory syndrome has not been well described. In this retrospective, single centre, cohort study, we describe the cardiac involvement found in this population and report on outcomes of patients with and without elevated cardiac biomarkers. Those with multi-system inflammatory syndrome in children, cardiomyopathy, or complex CHD were excluded. Inclusion criteriaz were met by 80 patients during the initial peak of the pandemic at our institution. High-sensitivity troponin T and/or N-terminal pro-brain type natriuretic peptide were measured in 27/80 (34%) patients and abnormalities were present in 5/27 (19%), all of whom had underlying comorbidities. Advanced respiratory support was required in all patients with elevated cardiac biomarkers. Electrocardiographic abnormalities were identified in 14/38 (37%) studies. Echocardiograms were performed on 7/80 patients, and none demonstrated left ventricular dysfunction. Larger studies to determine the true extent of cardiac involvement in children with COVID-19 would be useful to guide recommendations for standard workup and management.
Enter with Devils, giving crowns and rich apparel to Faustus, and dance and then depart.
Faustus: Speak, Mephistopheles. What means this show?
Mephistopheles: Nothing, Faustus, but to delight thy mind withal And to show thee what magic can perform.
From the mid-eighteenth century when interest in Doctor Faustus revived, critical attention on the play has largely focused on what may be termed its metaphysical concerns. Is Marlowe challenging conventional Christian perspectives on hell and heaven, or does his play ultimately conform with them? Is Faustus a tragic hero or a misguided sinner? Though scholarship on Doctor Faustus has increasingly complicated issues surrounding the origin and status of the play's two main versions, ideas of what may be termed high seriousness have dominated debate about its content. For both readers of a text and spectators at performances, attention is commonly concentrated on those scenes that engage most thoroughly with a tragic dimension. The scenes of farce attract much less attention. But what type of play engaged early spectators? How might Doctor Faustus have been performed in the theatres of Elizabethan England? This chapter seeks to re-examine the modern preoccupation with Faustus as metaphysical tragedy by thinking about it in the cultural milieu from which it first arose. Interestingly, many of the issues raised by the place of the stage in early modern London still seem to resonate strangely within current critical debates about Doctor Faustus.
Stress levels imparted on a cell have been shown to alter cell organization and function, presumably as a result of morphological cues affecting cytoskeletal organization. Materials with spatially resolved surface chemistry were designed to isolate individual mammalian cells to determine the influence of projected area on cell proliferation and cytoskeletal organization. Surfaces were fabricated using a photolithographic process resulting in islands of cell binding N-(2-aminoethyl)-3-aminopropyl-trimethoxysilane (EDS) separated by a non-adhesive interpenetrating polymer network [poly acrylamide-co-ethylene glycol; P(AAm-co-EG)]. The surfaces contained over 3800 adhesive islands/cm2, allowing for isolation of single cells with projected areas ranging from 100µm2to 10,000µm2. These surfaces provide a useful tool for researching how cell morphology and mechanical forces affect cell function.