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Approximately one in twenty men have sperm counts low enough to impair fertility but little progress has been made in answering fundamental questions in andrology or in developing new diagnostic tools or management strategies in infertile men. Many of these problems increase with age, leading to a growing population of men seeking help. To address this, there is a strong movement towards integrating male reproductive and sexual healthcare involving clinicians such as andrologists, urologists, endocrinologists and counselors. This book will emphasize this integrated approach to male reproductive and sexual health throughout the lifespan. Practical advice on how to perform both clinical and laboratory evaluations of infertile men is given, as well as a variety of methods for medically and surgically managing common issues. This text ties together the three major pillars of clinical andrology: clinical care, the andrology laboratory, and translational research.
Catullan Questions Revisited offers a new insight into the brilliant poet who loved an aristocratic girl, attacked Julius Caesar and became a satirical playwright. Insisting on scrupulous use of the primary sources, Peter Wiseman combines textual, historical and even archaeological evidence to explode the orthodox view of Catullus' life and work. 'Lesbia' was not a woman in her thirties, as has been believed for 150 years, but a girl only recently married; Catullus' poems were written for performance, private or public, and it was only in 54 BC, at what he saw as the turning-point of his life, that he collected their texts into a sequence of probably seven volumes. His subsequent literary career, equally successful but much less well attested, was as a 'mime'-dramatist. This book is intended for everyone who is interested in poetry and history, and who does not believe that literary texts exist in a vacuum.
In this book, T. L. Short places the notorious difficulties of Peirce's important writings in a more productive light, arguing that he wrote philosophy as a scientist, by framing conjectures intended to be refined or superseded in the inquiries they initiate. He argues also that Peirce held that the methods and metaphysics of modern science are amended as inquiry progresses, making metaphysics a branch of empirical knowledge. Additionally, Short shows that Peirce's scientific work expanded empiricism on empirical grounds, grounding his phenomenology and subverting the fact/value dichotomy, and that he understood statistical explanations in nineteenth-century science as reintroducing the idea of final causation, now made empirical. Those innovations underlie Peirce's late ideas of a normative science and of philosophy as a branch of science. Short's rich and original study shows us how to read Peirce's writings and why they are worth reading.
Does interpersonal political communication improve the quality of individual decision making? While deliberative theorists offer reasons for hope, experimental researchers have demonstrated that biased messages can travel via interpersonal social networks. We argue that the value of interpersonal political communication depends on the motivations of the people involved, which can be shifted by different contexts. Using small-group experiments that randomly assign participants' motivations to seek or share information with others as well as their motivations for evaluating the information they receive, we demonstrate the importance of accounting for motivations in communication. We find that when individuals with more extreme preferences are motivated to acquire and share information, collective civic capacity is diminished. But if we can stimulate the exchange of information among individuals with stronger prosocial motivations, such communication can enhance collective civic capacity. We also provide advice for other researchers about conducting similar group-based experiments to study political communication.
Archaeoprimatology intertwines archaeology and primatology for understanding the ancient liminal relationships between humans and nonhuman primates. During the last decade novel studies have boosted this discipline. This edited volume is the first compendium of archaeoprimatological studies ever produced. Written by a culturally diverse group of scholars, with multiple theoretical views and methodological perspectives, it covers new zooarchaeological examinations and material culture evaluations, as well as innovative uses of oral and written sources. Themes covered comprise the survey of past primates as pets, symbolic mediators, prey, iconographic references, or living commodities. The book covers different regions of the world, from the Americas to Asia, along with studies from Africa and Europe. Temporally, the chapters explore the human-nonhuman primate interface from deep in time to more recent historical times, covering both extinct and extant primate taxa. This anthology of archaeoprimatological studies will be of interest to archaeologists, primatologists, anthropologists, art historians, paleontologists, conservationists, zoologists, historical ecologists, philologists, and ethnobiologists.
High-frequency continuous deep brain stimulation (DBS) is an effective therapy for many motor symptoms of movement disorders but has limitations related to time-consuming device programming and maintenance. Expert clinicians typically program devices in a trial-and-error fashion with established techniques such as the monopolar review. Multiple visits are often required to determine long-term DBS settings and dopaminergic medication dosing based on direct clinical observation.
This volume of Proclus' commentary on Plato's Timaeus records Proclus' exegesis of Timaeus 27a–31b, in which Plato first discusses preliminary matters that precede his account of the creation of the universe, and then moves to the account of the creation of the universe as a totality. For Proclus this text is a grand opportunity to reflect on the nature of causation as it relates to the physical reality of our cosmos. The commentary deals with many subjects that have been of central interest to philosophers from Plato's time onwards, such as the question whether the cosmos was created in time, and the nature of evil as it relates to physical reality and its ontological imperfection.
Five-hundred years ago, Europeans finally “discovered” Malay, the undisputed language of Southeast Asian commerce and diplomacy of that time. In this chapter, we look into the role of Malay in the early modern era so we can understand the processes that have contributed to its continued diffusion and diversification in this century. We look at the spread of Malay, not by mass migration, but through language convergence and language shift. Malay, whether a national language (named Malay and Indonesian) or a local dialect spoken by a small ethnic minority, is one of the world’s major languages. Its geographic and demographic expansion can be linked to numerous factors, among them: language shift as a component of broader cultural change; consolidation of diverse ethnicities; immigrant accommodation to the majority population; and early use in national educational systems. But the underlying basis and strength of Malay is its centuries old geographic and societal diffusion. On the one hand, its national-language status has triggered the significant growth we are witnessing now. On the other hand, the creativity of its speakers using diverse social and regional dialects sustains that growth, reflected in its large profile in today’s electronic media, such as Facebook.
This article draws from Charles Taylor’s work of retrieval to advance moral foundations theory (MFT). Taylor’s contribution to MFT lies in his insistence that we retrieve the moral sources that have helped constitute, substantiate, and give meaning to individuals’ moral sensibilities. Applying Taylor’s insights to MFT, this article seeks to advance a view of moral foundations that connects them more explicitly to their underlying moral sources. Using this retrieved account of moral foundations, this article then addresses current issues within moral foundations research and theory. Finally, this article suggests ways in which Taylor’s philosophy can contribute to three areas within business ethics: ethical leadership, behavioral ethics, and ethics pedagogy.
To understand barriers and facilitators to evidence-based prescribing of antibiotics in the outpatient dental setting.
Design:
Semistructured interviews.
Setting:
Outpatient dental setting.
Participants:
Dentists from 40 Veterans’ Health Administration (VA) facilities across the United States.
Methods:
Dentists were identified based on their prescribing patterns and were recruited to participate in a semistructured interview on perceptions toward prescribing. All interviews were recorded, transcribed, and double-coded for analysis, with high reliability between coders. We identified general trends using the theoretical domains framework and mapped overarching themes onto the behavior change wheel to identify prospective interventions that improve evidence-based prescribing.
Results:
In total, 90 dentists participated in our study. The following barriers and facilitators to evidence-based prescribing emerged as impacts on a dentist’s decision making on prescribing an antibiotic: access to resources, social influence of peers and other care providers, clinical judgment, beliefs about consequences, local features of the clinic setting, and beliefs about capabilities.
Conclusions:
Findings from this work reveal the need to increase awareness of up-to-date antibiotic prescribing behaviors in dentistry and may inform the best antimicrobial stewardship interventions to support dentists’ ongoing professional development and improve evidence-based prescribing.
Increasing interest in three-dimensional nanostructures adds impetus to electron microscopy techniques capable of imaging at or below the nanoscale in three dimensions. We present a reconstruction algorithm that takes as input a focal series of four-dimensional scanning transmission electron microscopy (4D-STEM) data. We apply the approach to a lead iridate, Pb$_2$Ir$_2$O$_7$, and yttrium-stabilized zirconia, Y$_{0.095}$Zr$_{0.905}$O$_2$, heterostructure from data acquired with the specimen in a single plan-view orientation, with the epitaxial layers stacked along the beam direction. We demonstrate that Pb–Ir atomic columns are visible in the uppermost layers of the reconstructed volume. We compare this approach to the alternative techniques of depth sectioning using differential phase contrast scanning transmission electron microscopy (DPC-STEM) and multislice ptychographic reconstruction.
To investigate factors that influence antibiotic prescribing decisions, we interviewed 49 antibiotic stewardship champions and stakeholders across 15 hospitals. We conducted thematic analysis and subcoding of decisional factors. We identified 31 factors that influence antibiotic prescribing decisions. These factors may help stewardship programs identify educational targets and design more effective interventions.
Understanding edge-localised-mode (ELM)-free high-confinement (H-)mode scenarios is vital for developing practical future demonstration reactor scenarios. An argon-seeded EDA H-mode discharge performed in ASDEX Upgrade is computationally studied in detail for the first time with the gyrokinetic GENE code using experimental profiles and magnetic equilibrium as direct code inputs. Linear scans outline dominant instabilities in the regime and reveal distinct ion- and electron-scale wavenumber growth-rate peaks for two local core and two local pedestal top scenarios. Linear ion-scale growth rates are found to be relatively insensitive to the addition of argon, and collisionality scans demonstrate increased sensitivity in the pedestal top. The addition of an argon impurity profile while keeping the input main ion temperature gradient (ITG) largely unchanged is found to reduce ITG-driven turbulence in the outer core. Nonlinear electromagnetic simulations reveal close agreement with experimentally predicted heat fluxes in the core, outline key sensitivities to electron $\beta$ and background $\boldsymbol{E\times B}$ shearing, and reveal gyrokinetic challenges in analysing the quasicoherent mode. Global electrostatic nonlinear simulations reduce local simulated heat transport overpredictions at the pedestal top. A quasilinear analysis finds that there is good core agreement but poor agreement in the pedestal between linear and nonlinear temperature and density fluctuation cross-phases. Local simulation limitations are elucidated and paths forward for future computation are suggested.
The unmanned aerial vehicle (UAV) flocking among obstacles was transferred to a velocity-controllable UAV flocking problem, which means that multi-UAV gradually form and maintain the
$\alpha$
-lattice geometry as they track the desired flocking velocity, and can be applied to tasks such as obstacle avoidance and velocity tracking. Velocity-controllable UAV flocking problem is a multi-objective flocking controller parameters optimisation problem, for which we design flocking velocity and geometry objective function, and solve them using a multi-objective particle swarm optimisation algorithm (MOPSO). On this basis, to address the problem that MOPSO has random results and long computation time, we propose to use a neural network (NN) to approximate the mathematical relationship between the UAV flocking state and the flocking controller parameters. We simulate the flight process of 5 and 49 UAVs performing obstacle avoidance and velocity tracking tasks, respectively. The results show that the proposed UAV flocking controller has better convergence performance, obtains reproducible results, reduces computation time, and can be used for large-scale UAV flocking control.
Joint programs are an alternative model that may aid in improving congenital cardiac surgery outcomes while avoiding the potential resource and accessibility challenges that could result from regionalization. This study aims to characterize current joint programs, identify factors that are associated with joint program success and failure, and gauge attitudes within the profession regarding joint programs as an alternative.
Methods:
A multiple choice survey with 23 standard questions for all participants and additional 42 additional questions for each participant hospital in a joint program was addressed to pediatric cardiac surgeons in the US. Questions were designed to qualitatively and quantitatively characterize congenital cardiac surgery joint programs.
Results:
Of the 34 unique congenital cardiac surgery programs identified in this survey, 14 have participated in a joint program and 50% of those joint programs existed for more than 10 years. Most joint programs (86%) participate or participated in a model where participants are engaged in a “mother-daughter” relationship in both perception and case volume distribution. In 3 out of 4 defunct joint programs, there were case complexity limitations placed on partner institutions, but the now independent partner institutions operate with no limitation on complexity. Most (71%) of participants in a joint program felt that the joint program produced better outcomes than two separate programs; however, among those who participate or have participated in a joint program, only 18% felt that joint programs were the optimal model for delivery of congenital cardiac surgical care.
Stochastic models of varying complexity have been proposed to describe the dispersion of particles in turbulent flows, from simple Brownian motion to complex temporally and spatially correlated models. A method is needed to compare competing models, accounting for the difficulty in estimating the additional parameters that more complex models typically introduce. We employ a data-driven method, Bayesian model comparison, which assigns probabilities to competing models based on their ability to explain observed data. We focus on the comparison between the Brownian and Langevin dynamics for particles in two-dimensional isotropic turbulence, with data that consist of sequences of particle positions obtained from simulated Lagrangian trajectories. We show that, while on sufficiently large time scales the models are indistinguishable, there is a range of time scales on which the Langevin model outperforms the Brownian model. While our set-up is highly idealised, the methodology developed is applicable to more complex flows and models of particle dynamics.
We use Supreme Court amicus curiae briefs filed by seven religious groups—four liberal and three conservative—to understand the changing nature of political conflict between American religious groups in the predominantly White Protestant tradition from 1969 to 2020. Religious groups on both sides of the ideological divide have increased the frequency of their amicus filings, and increasingly become involved in issue areas which were once primarily the concern of groups on the other side. These findings suggest that the culture war that redefined party politics in America has also shaped religious activism, including legal activism. We argue that these groups have increased their involvement in a wider range of issues for two reasons: their rivalry for influence over the nation's moral center has become more encompassing and overtly political, and their appreciation for and consciously developed ability to tap into the courts' influence on American politics has grown.