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Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD).
We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years).
As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD.
Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.
The present study examines whether illusory movement (IM) of a
horizontal line, induced by a moving background (MB), influences
line-bisection performance in normal subjects. The first experiment
attempted to identify the speeds of MB that induce IM. We found that when
speed is increased from 1.53° to 13.3°/sec, IM increases, but
that with further speed increases, IM decreases. Leftward MB induces
rightward IM, and vice versa. In the second experiment, we had subjects
bisect lines at MB speeds that had been shown to induce IM in the first
experiment. We found that leftward MB induced a rightward bias, and vice
versa. We also found that there was a relationship between the magnitude
of IM and the degree of bias. In the third experiment, by making the
target line larger than the MB, we made the conditions where IM was
presumably absent. Unlike the results of bisection performed with IM,
subjects showed a bias in the direction of the MB. Overall, these
experiments demonstrated that the perception of motion induces subjects to
attend in the direction of movement. (JINS, 2005, 11,
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