Using an original demographically representative survey, we estimate the determinants of public support for a set of supportive and punitive policies to combat the opioid epidemic among a sample of 2,131 Americans. Our findings indicate that individuals who attribute blame for the epidemic to the personal choices of individuals, conservatives and those high in racial resentment are consistently more likely to support punitive policies to combat the opioid epidemic and less likely to favour policies to support individuals with substance use disorders. Individuals who have a personal connection to someone struggling with opioid use disorder favour policies to support such individuals but have nuanced attitudes towards punitive policies. Importantly, we find overwhelming support for all supportive policies except supervised injection sites, while roughly 50% of our sample supported the set of punitive policy choices. Our research represents a significant step forward toward understanding public opinion about the opioid epidemic and policies to combat it.

Musculoskeletal models, like all theoretical models of physical processes, depend on the assumptions needed to construct the model. For musculoskeletal models, these assumptions include, among other things, the kinematic data, the kinetic data and the muscle parameters. The former (dynamic) data can be acquired relatively easily from living subjects, but the latter are usually based on limited information, frequently determined from cadaver studies performed on elderly individuals. Previously, we determined the sensitivity of forces to dynamic differences among 10 humans walking on a straight path. Here, we assess the sensitivity of the muscle and joint reaction forces developed in human walking to variable muscle parameters obtained from 10 living adults, whose data were recently reported, and compared the results with the values from a standard model that depends on cadaveric data. We found that, while the force patterns across the stance cycle were similar among muscle parameter models, differences of as much as 15% in the force magnitude were produced. Whether or not the variation between the standard model and other muscle parameters is important depends on why the forces are required.