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School-based interventions to prevent obesity have shown heterogeneous results. Recent school-based trials with “negative” have cast doubt on their effectiveness. In the Juntos Santiago trial, we used an innovative, theory-based gamification strategy to increase motivation and participation in healthy behavioural changes. This is the first trial, to our knowledge, to use gamification to prevent childhood obesity.
Objective
To examine the effectiveness of a multicomponent gamification strategy to prevent obesity in 5th and 6th-grade schoolchildren in Santiago de Chile.
Materials and methods
School-based, parallel cluster-randomized controlled trial. 81 schools in two municipalities in Santiago, Chile, with more than 40 students in 5th and 6th grade altogether were eligible. Schools were randomized and sequentially invited to participate. The multicomponent intervention was a gamification strategy with four components: (i) healthy challenges (snacks, steps and healthy activities); (ii) gamification incentives, such as points, levels, leaderboards and badges; (iii) rewards (infrastructure and fun activity) and (iv) an online platform for parents and students to monitor the progress. Participants were followed up at 5 and 8 months. Pre-registered primary outcomes were body mass index (BMI) z-score and waist circumference (WC) at 8 months. Secondary outcomes were BMI and systolic (SBP) and diastolic blood pressure (DBP) at 8 months. Multilevel analysis adjusted for individual and school-level covariates were used.
Results
24 schools (9 controls) and 2333 students (709 controls) were assessed at baseline and 2264 students (689 controls) were assessed at 8 months. The mean BMI z-score was lower in the intervention group compared to the control group at 8 months (mean difference -0.132, 95% CI -0.249; -0.014), while no difference was observed for WC. Mean BMI and SBP were lower in the intervention arm compared to the control arm (mean difference for SBP -0.139; 95% CI -2.39; -0.40). No difference was observed for DBP.
Discussion
The gamification strategy appears to prevent childhood obesity and reduce systolic blood pressure in school children in Santiago. These effects are larger than the pooled effects from existing meta-analyses. Further research should identify which components of the gamification strategy were more effective.
‘Discourses of climate delay’ pervade current debates on climate action. These discourses accept the existence of climate change, but justify inaction or inadequate efforts. In contemporary discussions on what actions should be taken, by whom and how fast, proponents of climate delay would argue for minimal action or action taken by others. They focus attention on the negative social effects of climate policies and raise doubt that mitigation is possible. Here, we outline the common features of climate delay discourses and provide a guide to identifying them.
By
Lorenz A. Gilch, Know Center GmbH, Inffeldgasse 13, A-8010 Graz, Austria,
Sebastian Müller, Aix Marseille University, CNRS, Centrale Marseille, I2M, Marseille, France
We construct a renewal structure for random walks on surface groups. The renewal times are defined as times when the random walks enter a particular type of cone and never leave it again. As a consequence, the trajectory of the random walk can be expressed as an aligned union of independent and identically distributed trajectories between the renewal times. Once having established this renewal structure, we prove a central limit theorem for the distance to the origin under exponential moment conditions. Analyticity of the speed and of the asymptotic variance are natural consequences of our approach. Furthermore, our method applies to groups with infinitely many ends and therefore generalizes classic results on central limit theorems on free groups.
To understand the dynamics of ice shelves, a knowledge of their internal and basal structure is very important. As the capacity to perform local surveys is limited, remote sensing provides an opportunity to obtain the relevant information. We must prove, however, that the relevant information can be obtained from remote sensing of the surface. That is the aim of this study. The Jelbart Ice Shelf, Antarctica, exhibits a variety of surface structures appearing as stripe-like features in radar imagery. We performed an airborne geophysical survey across these features and compared the results to TerraSAR-X imagery. We find that the stripe-like structures indicate surface troughs coinciding with the location of basal channels and crevasse-like features, revealed by radio-echo sounding. HH and VV polarizations do not show different magnitude. In surface troughs, the local accumulation rate is larger than at the flat surface. Viscoelastic modelling is used to gain an understanding of the surface undulations and their origin. The surface displacement, computed with a Maxwell model, matches the observed surface reasonably well. Our simulations show that the surface troughs develop over decadal to centennial timescales.
Impaired social functioning and autistic symptoms are characteristics of schizophrenia. The social hormones oxytocin (OT) and arginine-vasopressin (AVP) both modulate social interaction and therefore may be involved in the pathogenesis of schizophrenia. We investigated whether men with schizophrenia show altered OT and AVP levels compared with healthy controls (HC) and whether autism symptoms are associated with OT levels.
Methods
Forty-one men with non-acute schizophrenia and 45 matched HC were enroled. Schizophrenia was assessed with the Positive and Negative Syndrome Scale (PANSS). Blood samples were collected on 2 days, and plasma OT and AVP levels were measured by ELISA immunoassay.
Results
The schizophrenia patients had significantly lower plasma OT levels than the HC; a similar trend was found for AVP. Plasma OT levels were associated with severe life events, fewer important attached persons, and a higher score on the PANSS negative scale; the most dominant PANSS items were ‘preoccupation’, ‘emotional withdrawal’, and ‘passive/apathetic social withdrawal’.
Conclusion
These findings support an association between the social hormones OT and AVP and schizophrenia. We suggest that OT metabolism may be altered in schizophrenia, but other possible causes for decreased plasma OT levels in schizophrenia patients include decreased OT synthesis, mRNA expression, and translation. Especially the ‘autistic’ symptoms of schizophrenia seem to be closely linked to an altered metabolism of OT, the ‘attachment’ hormone.
The European Convention on Human Rights (hereafter ECHR, or Convention) has gained more importance within the multi-level system of judicial protection of human rights in Germany in recent years. The number of adverse judgments against Germany delivered by the European Court of Human Rights (hereafter ECtHR, or Strasbourg Court) has been relatively low compared with other member states of the Council of Europe. In 2007 and 2008, the ECtHR found a violation of the Convention in seven and six judgments respectively. The number is even lower when one looks into the records before the Strasbourg Court became a permanent institution in 1998. However, since 2009 an increase of adverse judgments against Germany can be observed, with the ECtHR delivering twenty-nine adverse judgments in 2010 and thirty-one in 2011. Even though several of the judgments concerned repetitive cases, the Strasbourg Court has for the first time decided on significant topics like preventive detention in Germany. It also issued its first pilot judgment against Germany regarding excessive length of court proceedings, as well as judgments on freedom of expression and the protection of whistleblowers. The increase in adverse judgments, as well as the importance of the issues they involve, raise significant questions concerning the role of the ECtHR's judgments in the domestic system of human rights protection.
Indium has attracted much attention as a beneficial addition to cobalt–antimony-based skutterudites as a result of good thermoelectric performance. In this study, as-cast InxCo4Sb12 with x = 0.05, 0.2 were examined using x-ray diffraction analysis and scanning electron microscopy. For x = 0.2 we found, besides the skutterudite main phase, nanometer-sized regions of secondary phases distributed along the grain boundaries, which exhibit substructures. As-cast material with x = 0.05 does not show visible precipitates. We further observed that changing one of the heat treatment parameters of In0.2Co4Sb12 has a major effect on the microstructure and shape of the precipitates, but minor influence on the skutterudite matrix composition. Energy dispersive x-ray spectroscopy analysis by transmission electron microscopy) reveals that indium is to a large extent distributed into the skutterudite structure. Measurements of short-term sintered material confirm that the addition of indium and particularly the modification of the synthesis parameter entails to an enhanced ZT.
Spider walks are systems of interacting particles. The particles move independently as long as their movements do not violate some given rules describing the relative position of
the particles; moves that violate the rules are not realized. The goal of this paper is to study qualitative properties, as recurrence, transience, ergodicity, and positive rate of escape of these Markov processes.
ϵ Eridani hosts one known inner planet and an outer Kuiper belt analog. Further, Spitzer/IRS measurements indicate that warm dust is present at distances as close as a few AU from the star. Its origin is puzzling, since an “asteroid belt” that could produce this dust would be unstable because of the inner planet. We tested a hypothesis that the observed warm dust is generated by collisions in the outer belt and is transported inward by P-R drag and strong stellar winds. With numerical simulation we investigated how the dust streams from the outer ring into the inner system, and calculated the thermal emission of the dust. We show that the observed warm dust can indeed stem from the outer belt. Our models reproduce the shape and magnitude of the observed SED from mid-IR to sub-mm wavelengths, as well as the Spitzer/MIPS radial brightness profiles.
In the mammalian retina, neuronal nitric oxide
synthase (NOS) is mainly localized in subpopulations of
amacrine cells. One function of nitric oxide (NO) is to
stimulate soluble guanylate cyclases which in turn synthesize
cGMP. We used an antibody specific for cGMP to demonstrate
cGMP-like immunoreactivity (cG-IR) in bovine, rat, and
rabbit retinae and investigated the effects on cGMP levels
of both exogenously applied NO and of endogenously released
NO. We found that cGMP levels in inner and outer retina
were controlled in opposite ways. In the presence of the
NO-donors SNP, SIN-1 or SNAP, cG-IR was prominent in neurons
of the inner retina, mainly in cone bipolar cells, some
amacrine and ganglion cells. Retinae incubated in IBMX
showed weak cG-IR in bipolar cells. Glutamate increased
cG-IR in the inner retina, presumably by stimulating endogenous
NO release, whereas NOS inhibitors or GABA and glycine
decreased cG-IR in bipolar cells by reducing NO release.
In somata, inner segments and spherules of rod photoreceptors
the situation was reversed. cG-IR was undetectable in the
presence of NO-donors or glutamate, was moderate in IBMX-treated
retinae, but increased strongly in the presence of NOS
inhibitors or GABA/glycine. We conclude that NO is released
endogenously in the retina. In the presence of NO, cGMP
levels are increased in neurons of the inner retina, but
are decreased in rods.
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