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This Research Communication describes an investigation of the nutritional depletion of total mixed rations (TMR) by pest birds. We hypothesized that species-specific bird depredation of TMR can alter the nutritional composition of the ration and that these changes can negatively impact the performance of dairy cows. Blackbirds selected the high energy fraction of the TMR (i.e., flaked corn) and reduced starch, crude fat and total digestible nutrients during controlled feeding experiments. For Holsteins producing 37·1 kg of milk/d, dairy production modeling illustrated that total required net energy intake (NEI) was 35·8 Mcal/d. For the reference TMR unexposed to blackbirds and the blackbird-consumed TMR, NEI supplied was 41·2 and 37·8 Mcal/d, and the resulting energy balance was 5·4 and 2·0 Mcal/d, respectively. Thus, Holsteins fed the reference and blackbird-consumed TMR were estimated to gain one body condition score in 96 and 254 d, and experience daily weight change due to reserves of 1·1 and 0·4 kg/d, respectively. We discuss these results in context of an integrated pest management program for mitigating the depredation caused by pest birds at commercial dairies.
Surgical site infections (SSIs) following colorectal surgery (CRS) are among the most common healthcare-associated infections (HAIs). Reduction in colorectal SSI rates is an important goal for surgical quality improvement.
OBJECTIVE
To examine rates of SSI in patients with and without cancer and to identify potential predictors of SSI risk following CRS
DESIGN
American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data files for 2011–2013 from a sample of 12 National Comprehensive Cancer Network (NCCN) member institutions were combined. Pooled SSI rates for colorectal procedures were calculated and risk was evaluated. The independent importance of potential risk factors was assessed using logistic regression.
SETTING
Multicenter study
PARTICIPANTS
Of 22 invited NCCN centers, 11 participated (50%). Colorectal procedures were selected by principal procedure current procedural technology (CPT) code. Cancer was defined by International Classification of Disease, Ninth Revision, Clinical Modification (ICD-9-CM) codes.
MAIN OUTCOME
The primary outcome of interest was 30-day SSI rate.
RESULTS
A total of 652 SSIs (11.06%) were reported among 5,893 CRSs. Risk of SSI was similar for patients with and without cancer. Among CRS patients with underlying cancer, disseminated cancer (SSI rate, 17.5%; odds ratio [OR], 1.66; 95% confidence interval [CI], 1.23–2.26; P=.001), ASA score ≥3 (OR, 1.41; 95% CI, 1.09–1.83; P=.001), chronic obstructive pulmonary disease (COPD; OR, 1.6; 95% CI, 1.06–2.53; P=.02), and longer duration of procedure were associated with development of SSI.
CONCLUSIONS
Patients with disseminated cancer are at a higher risk for developing SSI. ASA score >3, COPD, and longer duration of surgery predict SSI risk. Disseminated cancer should be further evaluated by the Centers for Disease Control and Prevention (CDC) in generating risk-adjusted outcomes.
Prestige, authority and power: what is the significance of these three terms for the study of late-medieval manuscripts and texts? This collection of essays, by leading scholars from Britain and North America, answers this question in various ways: by discussing manuscripts as prestigious de luxe objects; by showing how the layout of texts was used to confer different kinds of authority; and by locating manuscripts and texts more dynamically in what Foucault calls 'power's net-like organisation'. All of the essays in the volume embed the manuscripts they discuss in particular sets of personal relationships, conducted in specific social environments - in the schoolroom or the monastery, at court, in the gentry household and the city, or mediating between these. The essays address, among others, issues of gender, patronage, status, self-authorization, and gentry and urban sociability, in studies ranging from the twelfth to the sixteenth centuries. Professor FELICITY RIDDY teaches in the Centre for Medieval Studies and the Department of English at the University of York. Contributors: SUZANNE REYNOLDS, KANTIK GHOSH, KATE HARRIS, KATHLEEN L. SCOTT, JOHN THOMPSON, CAROL M. MEALE, ANNE M. DUTTON, JAMES P. CARLEY, DAVID R. CARLSON
One variant of substance-use disorder is characterized by behavioral disinhibition. In this
report, we martial evidence for a model for the development of this variant. We hypothesize that
genetic liability for this variant is reflected in a spectrum of risk indicators linked to the inability
or unwillingness to inhibit behavioral impulses. Included in this spectrum are personality traits
suggesting low constraint, and externalizing psychopathology, including conduct, oppositional
defiant, and attention-deficit disorder in children and antisocial personality disorder and behavior
in adults. We further hypothesize that these individual differences in behavioral disinhibition are
manifestations of underlying central nervous system processes associated with various
psychophysiological anomalies, some of which may index genetic risk for substance abuse.
Support for the model is derived from the analysis of findings from the Minnesota Twin Family
Study, an epidemiological investigation of approximately 2,700 adolescent twins and their
parents.
To determine if the P300 component of the event-related
potential indexes risk for substance use and related disorders,
we presented a community sample of 377 16–18-year-old
males a visual oddball task and selected 31 subjects with
the smallest and 31 subjects with the largest P300 amplitudes.
An additional 31 subjects whose amplitudes fell in the
middle of the amplitude distribution were assigned to the
average group. The small and average amplitude groups were
more likely to have alcohol dependence and more symptoms
of alcohol dependence than the large amplitude subjects.
The small amplitude group had more symptoms of illicit
drug dependence than the other groups. There was also a
significantly larger proportion of subjects with externalizing
disorders in the small amplitude group than in the large
P300 group. These findings suggest that P300 amplitude
may index a spectrum of risk for disinhibited psychopathology.
To determine if the inability to take advantage
of the predictability of an aversive stimulus to diminish
its psychological impact reflects a deficit in inhibitory
control related to the development of substance dependence,
we recorded skin conductance responses (SCRs), heart rate
(HR), and anticipatory electrodermal nonspecific fluctuations
(NSFs) from 175 16–18-year-old boys when a white
noise blast was either unpredictable or temporally predictable.
Compared with boys who had moderately reduced or augmented
SCRs to predictable blasts (moderate and poor modulators,
respectively), boys whose SCRs were greatly reduced (good
modulators) had fewer symptoms of alcohol and nicotine
dependence and more anticipatory NSFs. HR appeared to index
an active coping response for good and moderate modulators.
The autonomic response pattern evident for good modulators
may index an inhibitory control mechanism protecting them
from developing substance dependence.
A new process route for lateral growth of nearly defect free GaN structures via Pendeo-epitaxy is discussed. Lateral growth of GaN films suspended from {110} side walls of [0001] oriented GaN columns into and over adjacent etched wells has been achieved via MOVPE technique without the use of, or contact with, a supporting mask or substrate. Pendeo-epitaxy is proposed as the descriptive term for this growth technique. Selective growth was achieved using process parameters that promote lateral growth of the {110} planes of GaN and disallow nucleation of this phase on the exposed SiC substrate. Thus, the selectivity is provided by tailoring the shape of the underlying GaN layer itself consisting of a sequence of alternating trenches and columns, instead of selective growth through openings in SiO2 or SiNx mask, as in the conventional lateral epitaxial overgrowth (LEO).
Two modes of initiation of the pendeo-epitaxial GaN growth via MOVPE were observed: Mode A - promoting the lateral growth of the {110} side facets into the wells faster than the vertical growth of the (0001) top facets; and Mode B - enabling the top (0001) faces to grow initially faster followed by the pendeo-epitaxial growth over the wells from the newly formed {110} side facets. Four-to-five order decrease in the dislocation density was observed via transmission electron microscopy (TEM) in the pendeo-epitaxial GaN relative to that in the GaN columns. TEM observations revealed that in pendeo-epitaxial GaN films the dislocations do not propagate laterally from the GaN columns when the structure grows laterally from the sidewalls into and over the trenches. Scanning electron microscopy (SEM) studies revealed that the coalesced regions are either defect-free or sometimes exhibit voids. Above these voids the PEGaN layer is usually defect free.
A new process route for lateral growth of nearly defect free GaN structures via Pendeoepitaxy is discussed. Lateral growth of GaN films suspended from {1120} side walls of [0001] oriented GaN columns into and over adjacent etched wells has been achieved via MOVPE technique without the use of, or contact with, a supporting mask or substrate. Pendeo-epitaxy is proposed as the descriptive term for this growth technique. Selective growth was achieved using process parameters that promote lateral growth of the { 1120) planes of GaN and disallow nucleation of this phase on the exposed SiC substrate. Thus, the selectivity is provided by tailoring the shape of the underlying GaN layer itself consisting of a sequence of alternating trenches and columns, instead of selective growth through openings in SiO2 or SiNx mask, as in the conventional lateral epitaxial overgrowth (LEO).
Two modes of initiation of the pendeo-epitaxial GaN growth via MOVPE were observed: Mode A - promoting the lateral growth of the {1120} side facets into the wells faster than the vertical growth of the (0001) top facets; and Mode B - enabling the top (0001) faces to grow initially faster followed by the pendeo-epitaxial growth over the wells from the newly formed {1120} side facets. Four-to-five order decrease in the dislocation density was observed via transmission electron microscopy (TEM) in the pendeo-epitaxial GaN relative to that in the GaN columns. TEM observations revealed that in pendeo-epitaxial GaN films the dislocations do not propagate laterally from the GaN columns when the structure grows laterally from the sidewalls into and over the trenches. Scanning electron microscopy (SEM) studies revealed that the coalesced regions are either defect-free or sometimes exhibit voids. Above these voids the PEGaN layer is usually defect free.