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Two experiments were conducted to understand the influence
of estrogen exposure on cardiovascular responses to acute
stress measured by impedance cardiography. Study 1 compared
stress responses of 29 postmenopausal women who used postmenopausal
hormone replacement therapy (HRT) and 29 who did not use
HRT. Women who did not use HRT had higher systolic blood
pressure and pulse pressure responses to the tasks relative
to HRT users. Study 2 compared stress responses of 38 healthy
postmenopausal women not initially on HRT who were randomly
assigned to transdermal estradiol or placebo treatment
for 6–8 weeks. HRT assignment did not influence substantially
women's cardiovascular responses to stress. Characteristics
correlated with HRT use, not HRT itself, or differences
in type, duration, and dosage may account for the discrepancy
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