Individuals with discordantly high apoB to LDL-cholesterol levels carry a higher risk of atherosclerotic CVD compared with those with average or discordantly low apoB to LDL-cholesterol. We aimed to determine associations between apoB and LDL-cholesterol discordance in relation to nutrient patterns (NP) using National Health and Nutrition Examination Survey data. Participants were grouped by established LDL-cholesterol and apoB cut-offs (Group 1: low apoB/low LDL-cholesterol, Group 2: low apoB/high LDL-cholesterol, Group 3: high apoB/low LDL-cholesterol, Group 4: high apoB/high LDL-cholesterol). Principle component analysis was used to define NP. Machine learning (ML) and structural equation models were applied to assess associations of nutrient intake with apoB/LDL-cholesterol discordance using the combined effects of apoB and LDL-cholesterol. Three NP explained 63·2 % of variance in nutrient consumption. These consisted of NP1 rich in SFA, carbohydrate and vitamins, NP2 high in fibre, minerals, vitamins and PUFA and NP3 rich in dietary cholesterol, protein and Na. The discordantly high apoB to LDL-cholesterol group had the highest consumption of the NP1 and the lowest consumption of the NP2. ML showed nutrients that had the greatest unfavourable dietary contribution to individuals with discordantly high apoB to LDL-cholesterol were total fat, SFA and thiamine and the greatest favourable contributions were MUFA, folate, fibre and Se. Individuals with discordantly high apoB in relation to LDL-cholesterol had greater adherence to NP1, whereas those with lower levels of apoB, irrespective of LDL-cholesterol, were more likely to consume NP3.

Optical parametric chirped-pulse amplification implemented using multikilojoule Nd:glass pump lasers is a promising approach for producing ultra-intense pulses (>1023 W/cm2). We report on the MTW-OPAL Laser System, an optical parametric amplifier line (OPAL) pumped by the Nd:doped portion of the multi-terawatt (MTW) laser. This midscale prototype was designed to produce 0.5-PW pulses with technologies scalable to tens of petawatts. Technology choices made for MTW-OPAL were guided by the longer-term goal of two full-scale OPALs pumped by the OMEGA EP to produce 2 × 25-PW beams that would be co-located with kilojoule−nanosecond ultraviolet beams. Several MTW-OPAL campaigns that have been completed since “first light” in March 2020 show that the laser design is fundamentally sound, and optimization continues as we prepare for “first-focus” campaigns later this year.

The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.

Gravitational waves from coalescing neutron stars encode information about nuclear matter at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced by the presence of tides, which depend on the neutron star equation of state. Neutron star mergers are expected to often produce rapidly rotating remnant neutron stars that emit gravitational waves. These will provide clues to the extremely hot post-merger environment. This signature of nuclear matter in gravitational waves contains most information in the 2–4 kHz frequency band, which is outside of the most sensitive band of current detectors. We present the design concept and science case for a Neutron Star Extreme Matter Observatory (NEMO): a gravitational-wave interferometer optimised to study nuclear physics with merging neutron stars. The concept uses high-circulating laser power, quantum squeezing, and a detector topology specifically designed to achieve the high-frequency sensitivity necessary to probe nuclear matter using gravitational waves. Above 1 kHz, the proposed strain sensitivity is comparable to full third-generation detectors at a fraction of the cost. Such sensitivity changes expected event rates for detection of post-merger remnants from approximately one per few decades with two A+ detectors to a few per year and potentially allow for the first gravitational-wave observations of supernovae, isolated neutron stars, and other exotica.

There has been little research investigating how mode of input affects incidental vocabulary learning, and no study examining how it affects the learning of multiword items. The aim of this study was to investigate incidental learning of L2 collocations in three different modes: reading, listening, and reading while listening. One hundred thirty-eight second-year college students learning EFL in Taiwan were randomly assigned to three experimental groups (reading, listening, reading while listening) and a no treatment control group. The experimental groups encountered 17 target collocations in the same graded reader. Learning was measured using two tests that involved matching the component words and recalling their meanings. The results indicated that the reading while listening condition was most effective while the reading and listening conditions contributed to similarly sized gains. The findings suggest that listening may play a more important role in learning collocations than single-word items.

Online learning has become an increasingly expected and popular component for education of the modern-day adult learner, including the medical provider. In light of the recent coronavirus pandemic, there has never been more urgency to establish opportunities for supplemental online learning. Heart University aims to be “the go-to online resource” for e-learning in CHD and paediatric-acquired heart disease. It is a carefully curated open access library of paedagogical material for all providers of care to children and adults with CHD or children with acquired heart disease, whether a trainee or a practising provider. In this manuscript, we review the aims, development, current offerings and standing, and future goals of Heart University.

We present a detailed guide to advanced collisionless fluid models that incorporate kinetic effects into the fluid framework, and that are much closer to the collisionless kinetic description than traditional magnetohydrodynamics. Such fluid models are directly applicable to modelling the turbulent evolution of a vast array of astrophysical plasmas, such as the solar corona and the solar wind, the interstellar medium, as well as accretion disks and galaxy clusters. The text can be viewed as a detailed guide to Landau fluid models and it is divided into two parts. Part 1 is dedicated to fluid models that are obtained by closing the fluid hierarchy with simple (non-Landau fluid) closures. Part 2 is dedicated to Landau fluid closures. Here in Part 1, we discuss the fluid model of Chew–Goldberger–Low (CGL) in great detail, together with fluid models that contain dispersive effects introduced by the Hall term and by the finite Larmor radius corrections to the pressure tensor. We consider dispersive effects introduced by the non-gyrotropic heat flux vectors. We investigate the parallel and oblique firehose instability, and show that the non-gyrotropic heat flux strongly influences the maximum growth rate of these instabilities. Furthermore, we discuss fluid models that contain evolution equations for the gyrotropic heat flux fluctuations and that are closed at the fourth-moment level by prescribing a specific form for the distribution function. For the bi-Maxwellian distribution, such a closure is known as the ‘normal’ closure. We also discuss a fluid closure for the bi-kappa distribution. Finally, by considering one-dimensional Maxwellian fluid closures at higher-order moments, we show that such fluid models are always unstable. The last possible non Landau fluid closure is therefore the ‘normal’ closure, and beyond the fourth-order moment, Landau fluid closures are required.

In Part 2 of our guide to collisionless fluid models, we concentrate on Landau fluid closures. These closures were pioneered by Hammett and Perkins and allow for the rigorous incorporation of collisionless Landau damping into a fluid framework. It is Landau damping that sharply separates traditional fluid models and collisionless kinetic theory, and is the main reason why the usual fluid models do not converge to the kinetic description, even in the long-wavelength low-frequency limit. We start with a brief introduction to kinetic theory, where we discuss in detail the plasma dispersion function $Z(\unicode[STIX]{x1D701})$, and the associated plasma response function $R(\unicode[STIX]{x1D701})=1+\unicode[STIX]{x1D701}Z(\unicode[STIX]{x1D701})=-Z^{\prime }(\unicode[STIX]{x1D701})/2$. We then consider a one-dimensional (1-D) (electrostatic) geometry and make a significant effort to map all possible Landau fluid closures that can be constructed at the fourth-order moment level. These closures for parallel moments have general validity from the largest astrophysical scales down to the Debye length, and we verify their validity by considering examples of the (proton and electron) Landau damping of the ion-acoustic mode, and the electron Landau damping of the Langmuir mode. We proceed by considering 1-D closures at higher-order moments than the fourth order, and as was concluded in Part 1, this is not possible without Landau fluid closures. We show that it is possible to reproduce linear Landau damping in the fluid framework to any desired precision, thus showing the convergence of the fluid and collisionless kinetic descriptions. We then consider a 3-D (electromagnetic) geometry in the gyrotropic (long-wavelength low-frequency) limit and map all closures that are available at the fourth-order moment level. In appendix A, we provide comprehensive tables with Padé approximants of $R(\unicode[STIX]{x1D701})$ up to the eighth-pole order, with many given in an analytic form.

The Godbillon–Vey invariant occurs in homology theory, and algebraic topology, when conditions for a co-dimension 1, foliation of a three-dimensional manifold are satisfied. The magnetic Godbillon–Vey helicity invariant in magnetohydrodynamics (MHD) is a higher-order helicity invariant that occurs for flows in which the magnetic helicity density $h_{m}=\boldsymbol{A}\boldsymbol{\cdot }\boldsymbol{B}=\boldsymbol{A}\boldsymbol{\cdot }(\unicode[STIX]{x1D735}\times \boldsymbol{A})=0$, where $\boldsymbol{A}$ is the magnetic vector potential and $\boldsymbol{B}$ is the magnetic induction. This paper obtains evolution equations for the magnetic Godbillon–Vey field $\unicode[STIX]{x1D6C8}=\boldsymbol{A}\times \boldsymbol{B}/|\boldsymbol{A}|^{2}$ and the Godbillon–Vey helicity density $h_{\text{gv}}=\unicode[STIX]{x1D6C8}\boldsymbol{\cdot }(\unicode[STIX]{x1D735}\times \unicode[STIX]{x1D6C8})$ in general MHD flows in which either $h_{m}=0$ or $h_{m}\neq 0$. A conservation law for $h_{\text{gv}}$ occurs in flows for which $h_{m}=0$. For $h_{m}\neq 0$ the evolution equation for $h_{\text{gv}}$ contains a source term in which $h_{m}$ is coupled to $h_{\text{gv}}$ via the shear tensor of the background flow. The transport equation for $h_{\text{gv}}$ also depends on the electric field potential $\unicode[STIX]{x1D713}$, which is related to the gauge for $\boldsymbol{A}$, which takes its simplest form for the advected $\boldsymbol{A}$ gauge in which $\unicode[STIX]{x1D713}=\boldsymbol{A}\boldsymbol{\cdot }\boldsymbol{u}$ where $\boldsymbol{u}$ is the fluid velocity. An application of the Godbillon–Vey magnetic helicity to nonlinear force-free magnetic fields used in solar physics is investigated. The possible uses of the Godbillon–Vey helicity in zero helicity flows in ideal fluid mechanics, and in zero helicity Lagrangian kinematics of three-dimensional advection, are discussed.

Excessive mobilization of body reserves during the transition from pregnancy to lactation imposes a risk for metabolic diseases on dairy cows. We aimed to establish an experimental model for high v. normal mobilization and herein characterized performance, metabolic and endocrine changes from 7 weeks antepartum (a.p.) to 12 weeks postpartum (p.p.). Fifteen weeks a.p., 38 pregnant multiparous Holstein cows were allocated to two groups that were fed differently to reach either high or normal body condition scores (HBCS: 7.2 NEL MJ/kg dry matter (DM); NBCS: 6.8 NEL MJ/kg DM) at dry-off. Allocation was also based on differences in body condition score (BCS) in the previous and the ongoing lactation that was further promoted by feeding to reach the targeted BCS and back fat thickness (BFT) at dry-off (HBCS: >3.75 and >1.4 cm; NBCS: <3.5 and <1.2 cm). Thereafter, both groups were fed identical diets. Blood samples were drawn weekly from 7 weeks a.p. to 12 weeks p.p. to assess the serum concentrations of metabolites and hormones. The HBCS cows had greater BCS, BFT and BW than the NBCS cows throughout the study and lost more than twice as much BFT during the first 7 weeks p.p. compared with NCBS. Milk yield and composition were not different between groups, except that lactose concentrations were greater in NBSC than in HBCS. Feed intake was also greater in NBCS, and NBCS also reached a positive energy balance earlier than HBCS. The greater reduction in body mass in HBCS was accompanied by greater concentrations of non-esterified fatty acids, and β-hydroxybutyrate in serum after calving than in NBCS, indicating increased lipomobilization and ketogenesis. The mean concentrations of insulin across all time-points were greater in HBCS than in NBCS. In both groups, insulin and IGF-1 concentrations were lower p.p than in a.p. Greater free thyroxine (fT4) concentrations and a lower free 3-3′-5-triiodothyronine (fT3)/fT4 ratio were observed in HBCS than in NBCS a.p., whereas p.p. fT3/fT4 ratio followed a reverse pattern. The variables indicative for oxidative status had characteristic time courses; group differences were limited to greater plasma ferric reducing ability values in NBSC. The results demonstrate that the combination of pre-selection according to BCS and differential feeding before dry-off to promote the difference was successful in obtaining cows that differ in the intensity of mobilizing body reserves. The HBCS cows were metabolically challenged due to intense mobilization of body fat, associated with reduced early lactation dry matter intake and compromised antioxidative capacity.

Optical parametric chirped-pulse amplification (OPCPA) [Dubietis et al., Opt. Commun. 88, 437 (1992)] implemented by multikilojoule Nd:glass pump lasers is a promising approach to produce ultraintense pulses (${>}10^{23}~\text{W}/\text{cm}^{2}$). Technologies are being developed to upgrade the OMEGA EP Laser System with the goal to pump an optical parametric amplifier line (EP OPAL) with two of the OMEGA EP beamlines. The resulting ultraintense pulses (1.5 kJ, 20 fs, $10^{24}~\text{W}/\text{cm}^{2}$) would be used jointly with picosecond and nanosecond pulses produced by the other two beamlines. A midscale OPAL pumped by the Multi-Terawatt (MTW) laser is being constructed to produce 7.5-J, 15-fs pulses and demonstrate scalable technologies suitable for the upgrade. MTW OPAL will share a target area with the MTW laser (50 J, 1 to 100 ps), enabling several joint-shot configurations. We report on the status of the MTW OPAL system, and the technology development required for this class of all-OPCPA laser system for ultraintense pulses.

Post-war planning and rebuilding of Britain's towns and cities led to rapid changes in medieval building stock, topography and character, as well as below-ground archaeology. Two case-studies of large, industrial, bomb-damaged yet important former medieval towns are examined in this article: Southampton and Coventry. Together, they illustrate the range of local responses to protecting what we now term the ‘historic environment’ in the period 1945 to 1955 at a time when a limited protection mechanism was introduced through the 1947 Town and Country Planning Act. The responsibility for compiling lists of protected buildings and providing resources to protect them largely fell to local solutions. Using previously unpublished archive material from both national and local sources, this article offers an alternative ‘bottom-up’, local, organized grass-roots viewpoint to most official ‘top-down’ accounts.

There is substantial evidence of an inverse association between birth weight and later blood pressure (BP) in populations from high-income countries, but whether this applies in low-income countries, where causes of low birth weight are different, is not certain. Objective: We conducted a review of the evidence on the relationship between birth weight and BP among African children and adolescents. Medline, EMBASE, Global Health and Web of Science databases were searched for publications to October 2016. Papers reporting the relationship between birth weight and BP among African children and adolescents were assessed. Bibliographies were searched for further relevant publications. Selected papers were summarized following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. In total, 16 papers from 13 studies conducted in nine African countries (Nigeria, Republic of Seychelles, Gambia, Democratic Republic of Congo, Cameroon, South Africa, Algeria, Zimbabwe and Angola) were reviewed. Eight studies were cohorts, while five were cross-sectional. The relationship between birth weight and later BP varied with age of the participants. Studies in neonates showed a consistently positive association, while predominantly inverse associations were seen among children, and studies in adolescents were inconsistent. Based on the limited number of studies identified, the relationship between birth weight and later BP may vary with age in African children and adolescents. Not all studies adequately controlled for confounding, notably gender or age. Whether the inverse relationship between birth weight and BP in later life observed in Western settings is also seen in Africa remains unclear.

In 1964 (Solar Cycle 20; SC 20), Patrick McIntosh began creating hand-drawn synoptic maps of solar magnetic features, based on Hα images. These synoptic maps were unique in that they traced magnetic polarity inversion lines, and connected widely separated filaments, fibril patterns, and plage corridors to reveal the large-scale organization of the solar magnetic field. Coronal hole boundaries were later added to the maps, which were produced, more or less continuously, into 2009 (i.e., the start of SC 24). The result was a record of ~45 years (~570 Carrington rotations), or nearly four complete solar cycles of synoptic maps. We are currently scanning, digitizing and archiving these maps, with the final, searchable versions publicly available at NOAA's National Centers for Environmental Information. In this paper we present preliminary scientific studies using the archived maps from SC 23. We show the global evolution of closed magnetic structures (e.g., sunspots, plage, and filaments) in relation to open magnetic structures (e.g., coronal holes), and examine how both relate to the shifting patterns of large-scale positive and negative polarity regions.

We examined reported policies for the control of common multidrug-resistant organisms (MDROs) in US healthcare facilities using data from the National Healthcare Safety Network Annual Facility Survey. Policies for the use of Contact Precautions were commonly reported. Chlorhexidine bathing for preventing MDRO transmission was also common among acute care hospitals.

Infect Control Hosp Epidemiol 2016:1–4