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239 results

Page 1 of 12

  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 222 / Issue 2 / February 2023
  • Published online by Cambridge University Press: 30 January 2023, pp. 93-94
  • Print publication: February 2023
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 221 / Issue 6 / December 2022
  • Published online by Cambridge University Press: 21 November 2022, pp. 771-772
  • Print publication: December 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 221 / Issue 5 / November 2022
  • Published online by Cambridge University Press: 24 October 2022, pp. 709-710
  • Print publication: November 2022
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  • Neuroimaging oxytocin modulation of social reward learning in schizophrenia
  • Elias D. Mouchlianitis, Derek K. Tracy, Rebekah Wigton, Lucy D. Vanes, Anne-Kathrin Fett, Sukhi S. Shergill
  • Journal: BJPsych Open / Volume 8 / Issue 5 / September 2022
  • Published online by Cambridge University Press: 26 September 2022, e175
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  • View abstract
    Background

    Conventional pharmacological approaches have limited effectiveness for schizophrenia. There is interest in the application of oxytocin, which is involved in social cognition. Clinical trials have yielded mixed results, with a gap in understanding neural mechanisms.

    Aims

    To evaluate the behavioural impact of oxytocin administration on a social learning task in individuals with schizophrenia, and elucidate any differential neural activity produced.

    Method

    We recruited 20 clinically stable right-handed men diagnosed with schizophrenia or schizoaffective disorder. In a double-blind cross-over randomised controlled study, 40 IU of oxytocin or placebo were administered before functional magnetic resonance imaging of participants playing a multi-round economic exchange game of trust. Participants had the role of investors (investment trials) receiving repayment on their investments (repayment trials), playing one session against a computer and a second against a player believed to be human.

    Results

    During investment trials, oxytocin increased neural signalling in the right lateral parietal cortex for both human and computer player trials, and attenuated signalling in the right insula for human player trials. For repayment trials, oxytocin elicited signal increases in left insula and left ventral caudate, and a signal decrease in right amygdala during the human player trials; conversely it resulted in right dorsal caudate activation during the computer player trials. We did not find a significant change in behavioural performance associated with oxytocin administration, or any associations with symptoms.

    Conclusions

    During a social learning task oxytocin modulates cortical and limbic substrates of the reward-processing network. These perturbations can be putatively linked to the pathoaetiology of schizophrenia.

  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 221 / Issue 4 / October 2022
  • Published online by Cambridge University Press: 26 September 2022, pp. 651-652
  • Print publication: October 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 221 / Issue 3 / September 2022
  • Published online by Cambridge University Press: 22 August 2022, pp. 585-586
  • Print publication: September 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 221 / Issue 2 / August 2022
  • Published online by Cambridge University Press: 18 July 2022, pp. 505-506
  • Print publication: August 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 221 / Issue 1 / July 2022
  • Published online by Cambridge University Press: 20 June 2022, pp. 435-436
  • Print publication: July 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 220 / Issue 6 / June 2022
  • Published online by Cambridge University Press: 23 May 2022, pp. 369-370
  • Print publication: June 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 220 / Issue 5 / May 2022
  • Published online by Cambridge University Press: 29 April 2022, pp. 307-308
  • Print publication: May 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 220 / Issue 4 / April 2022
  • Published online by Cambridge University Press: 31 March 2022, pp. 249-250
  • Print publication: April 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 220 / Issue 3 / March 2022
  • Published online by Cambridge University Press: 21 February 2022, pp. 167-168
  • Print publication: March 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 220 / Issue 2 / February 2022
  • Published online by Cambridge University Press: 24 January 2022, pp. 105-106
  • Print publication: February 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 220 / Issue 1 / January 2022
  • Published online by Cambridge University Press: 23 December 2021, pp. 47-48
  • Print publication: January 2022
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 219 / Issue 6 / December 2021
  • Published online by Cambridge University Press: 29 November 2021, pp. 701-702
  • Print publication: December 2021
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 219 / Issue 5 / November 2021
  • Published online by Cambridge University Press: 15 November 2021, pp. 624-625
  • Print publication: November 2021
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 219 / Issue 4 / October 2021
  • Published online by Cambridge University Press: 27 September 2021, pp. 573-574
  • Print publication: October 2021
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  • Kaleidoscope
  • Derek K. Tracy, Dan W. Joyce, Dawn N. Albertson, Sukhwinder S. Shergill
  • Journal: The British Journal of Psychiatry / Volume 219 / Issue 3 / September 2021
  • Published online by Cambridge University Press: 25 August 2021, pp. 527-528
  • Print publication: September 2021
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Page 1 of 12