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2 results

  • Worldwide incidence of cervical lesions: a systematic review

  • J. TING, A. F. ROSITCH, S. M. TAYLOR, L. RAHANGDALE, H. M. SOETERS, X. SUN, J. S. SMITH
  • Journal:
    Epidemiology & Infection / Volume 143 / Issue 2 / January 2015
    Published online by Cambridge University Press:
    30 May 2014, pp. 225-241
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  • We conducted a systematic review summarizing data on incidence of high- and low-grade lesions in women with normal baseline cervical cytology, stratified by age (<30 and ⩾30 years), and baseline human papillomavirus (HPV) infection. Incidence of high- and low-grade lesions in women aged ⩾30 years with a baseline HPV infection increased over follow-up time (5–127 months), although incidence generally remained <10%. Without baseline HPV infection, incidence of high-grade lesions remained low over follow-up time (<5% over 5–122 months). Incidence of high-grade lesions in women aged ⩾30 years with baseline HPV infection appeared similar to that in women aged <30 years. In some women aged <30 years, high-grade lesions can develop relatively shortly after initial HPV infection. We observed an increase in low-grade lesions over time in women aged ⩾30 years with baseline HPV infection, potentially indicative of an HPV infection that is potentially progressing to higher grade lesions.