International travel is thought to be a major risk factor for developing gastrointestinal (GI) illness for UK residents. Here, we present an analysis of routine laboratory and exposure surveillance data from North East (NE) England, describing the destination-specific contribution that international travel makes to the regional burden of GI infection.

Laboratory reports of common notifiable enteric infections were linked to exposure data for cases reported between 1 January 2013 and 31 December 2022. Demographic characteristics of cases were described, and rates per 100,000 visits were determined using published estimates of overseas visits from the Office for National Statistics (ONS) International Passenger Survey (IPS).

About 34.9% of cases reported international travel during their incubation period between 2013 and 2022, although travel-associated cases were significantly reduced (>80%) during the COVID-19 pandemic. Between 2013 and 2019, half of Shigella spp. and non-typhoidal Salmonella infections and a third of Giardia sp., Cryptosporidium spp., and Shiga toxin-producing Escherichia coli (STEC) infections were reported following travel. Rates of illness were highest in travellers returning from Africa and Asia (107.8 and 61.1 per 100,000 visits), with high rates also associated with tourist resorts like Turkey, Egypt, and the Dominican Republic (386.4–147.9 per 100,000 visits).

International travel is a major risk factor for the development of GI infections. High rates of illness were reported following travel to both destinations, which are typically regarded as high-risk and common tourist resorts. This work highlights the need to better understand risks while travelling to support the implementation of guidance and control measures to reduce the burden of illness in returning travellers.

The Greenland Ice Sheet has become an increasingly larger contributor to sea level rise in the past two decades and is projected to continue to lose mass. Climate variability is expected to increase under future warming, but the effect of climate variability on the Greenland Ice Sheet volume is poorly understood and is adding to the uncertainty of the projected mass loss. Here we quantify the influence of inter-annual temperature variability on mass loss from the Greenland Ice Sheet using the PISM model. We construct an ensemble of temperature-forcing fields that accounts for inter-annual variability in temperature using reanalysis data from NOAA-CIRES over the period 1851–2014. We investigate the steady-state and transient response of the Greenland Ice Sheet. We find that the simulated steady-state ice-sheet volume decreases by 1.9 ± 0.4 cm of sea level equivalent when forced with a varying temperature forcing compared to a constant temperature forcing, and by 11.5 ± 1.4 cm when the variability is doubled. The northern basins are particularly sensitive with a change in volume of 0.9–1.1%. Our results emphasize the importance of including temperature variability in projections of future mass loss.

Precision Medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. Autoimmune diseases are those in which the body’s natural defense system loses discriminating power between its own cells and foreign cells, causing the body to mistakenly attack healthy tissues. These conditions are very heterogeneous in their presentation and therefore difficult to diagnose and treat. Achieving precision medicine in autoimmune diseases has been challenging due to the complex etiologies of these conditions, involving an interplay between genetic, epigenetic, and environmental factors. However, recent technological and computational advances in molecular profiling have helped identify patient subtypes and molecular pathways which can be used to improve diagnostics and therapeutics. This review discusses the current understanding of the disease mechanisms, heterogeneity, and pathogenic autoantigens in autoimmune diseases gained from genomic and transcriptomic studies and highlights how these findings can be applied to better understand disease heterogeneity in the context of disease diagnostics and therapeutics.

The young open cluster NGC 6231 hosts a rich population of O-type binary stars. We study several of these eccentric short-period massive eclipsing binaries and assess their fundamental parameters. The properties of these systems make them interesting targets to study tidally induced apsidal motion. The analysis of apsidal motion offers a powerful means to obtain information about the internal structure of the stars. Indeed, since the rate of apsidal motion in a binary system is proportional to the internal structure constants of the stars composing it, its value gives direct insight into the internal structure and evolutionary state of these stars. Stellar evolution models are constructed based on the observationally-determined fundamental parameters and a theoretical rate of apsidal motion is inferred. The results are striking: Adopting standard stellar evolution models yields a theoretical rate of apsidal motion much larger than the observational value. This discrepancy results from the standard models predicting too low an efficiency of internal mixing and thus too homogenous stars in terms of density. By enforcing the theoretical rates of apsidal motion to match the observational values, enhanced mixing is required, through a large overshooting parameter and/or additional turbulent/rotational mixing. Our analysis leads to the conclusion that the chemically mixed cores in those massive stars must be more extended than anticipated from standard models.

Given the current lack of experimental data for shock waves interacting with incoming transitional boundary layers, the goal of this study was to characterize the dynamics of such an interaction to better understand the fundamental fluid physics of these complex phenomena. Here, the mean flow field and time-dependent characteristics of a three-dimensional Mach 5 cylinder-induced shock-wave/boundary-layer interaction where the upstream boundary layer is transitional, have been studied experimentally. The interactions were generated with a right circular cylinder mounted on a flat plate. Streamwise–spanwise planar laser scattering from a condensed alcohol fog and schlieren imaging were used to characterize the mean and instantaneous structure of the interaction, and fast-response wall-pressure measurements on the centreline upstream of the cylinder enabled characterization of the unsteadiness. The pressure measurements show a mean pressure profile that resembles a composite of an upstream laminar profile and a downstream turbulent profile. The upstream influence location of the transitional interaction was approximately 8.5 diameters ($d$) upstream of the cylinder leading edge, which is between that of a laminar and a turbulent interaction, and is followed by a plateau region to approximately $4d$ upstream of the cylinder. The plateau region is a region with a thicker boundary layer and possible flow separation. The plateau pressure was within 7 % of the value predicted by Hill's correlation for free-interaction phenomena. Furthermore, a statistical analysis of the pressure histories suggests that the entire interaction stretches and contracts in concert. Power spectral densities of the pressure fluctuations showed unsteadiness throughout the interaction with energy content primarily centred between a region defined by a separation-length-based Strouhal number $St_{L} = 0.05\text {--}0.2$, comparing well with other related studies of cylinder-induced interactions. Cross-correlations and coherence functions in the interaction suggest that the unsteadiness in the laminar region may be due to the entire ‘laminar’ region oscillating in response to the ‘turbulent’ unsteadiness of the intermittent region.

L’Organisation mondiale de la santé (OMS) définit l’empowerment comme faisant « référence au niveau de choix, de décision, d’influence et de contrôle que les usagers des services de santé mentale peuvent exercer sur les événements de leur vie (…). La clé de l’empowerment se trouve dans la transformation des rapports de force et des relations de pouvoir entre les individus, les groupes, les services et les gouvernements » (Wallerstein, 2006). L’OMS mentionne également les aidants dans le Pacte européen pour la santé mentale et le bien-être (2004, 2007) : « L’empowerment des personnes avec un problème de santé mentale et des aidants sont des priorités pour la prochaine décennie ». Suite aux 4e rencontres internationales du centre collaborateur de l’OMS pour la recherche et la formation en santé mentale (CCOMS, Lille, France), 21 recommandations en faveur de l’empowerment des usagers des services de santé mentale et des aidants ont été définies (document disponibles : http://www.ccomssantementalelillefrance.org/?q=promotion-des-indicateurs-d%E2 %80 %99empowerment). Cette première étape est le fruit d’un travail conjoint entre usagers, aidants, élus et professionnels. Une seconde étape, en cours, consiste à associer des indicateurs d’empowerment permettant de dresser une cartographie de l’empowerment en santé mentale en Europe. Cette communication présentera le concept d’empowerment en santé mentale, la promotion de cette notion par l’OMS et les 21 recommandations. La discussion portera sur la question fondamentale suivante : comment promouvoir de manière concrète ces recommandations ?

The horticultural industry is an important source of invasive ornamental plant species, which is part of the motivation for an increased emphasis on using native alternatives. We were interested in the possibility that plants marketed in the midwestern United States as the native Celastrus scandens, or American bittersweet, were actually the difficult-to-distinguish invasive Celastrus orbiculatus (oriental bittersweet) or hybrids of the two species. We used nuclear microsatellite DNA loci to compare the genetic identities of 34 plants from 11 vendors with reference plants from wild populations of known species identity. We found that 18 samples (53%) were mislabeled, and 7 of the 11 vendors sold mislabeled plants. Mislabeled plants were more likely to be purchased through Internet or phone order shipments and were significantly less expensive than accurately labeled plants. Vendors marketed mislabeled plants under five different cultivar names, as well as unnamed strains. Additionally, the most common native cultivar, ‘Autumn Revolution,’ displays reproductive characteristics that diverge from the typical C. scandens, which could be of some concern. The lower price and abundance of mislabeled invasive plants introduces incentives for consumers to unknowingly contribute to the spread of C. orbiculatus. Revealing the potential sources of C. orbiculatus is critical for controlling further spread of the invasive vine and limiting its impact on C. scandens populations.

Three-dimensionally phosphatized, spherical fossils, interpreted as metazoan eggs and embryos on the basis of taphonomic features and cleavage patterns, are reported for the first time from the Cambrian of North America. These microfossils occur with a phosphatized biota of skeletonized fossils, including specimens indicative of the earliest Cambrian Anabarites–Protohertzina Zone in the Wernecke Mountains of eastern Yukon Territory, northwestern Canada. They range in size from 0.25 mm to more than 1.0 mm in diameter and can be referred to two genera, Olivooides Qian, 1977 and Archaeooides Qian, 1977. The North American discovery extends the biogeographic range of earliest Cambrian eggs and embryos from coeval successions in China and Siberia, suggesting a wide geographic distribution of these taxa, and emphasizes the crucial role of local environmental and taphonomic conditions in preserving this phosphatic window into the record of early animal evolution. In addition to previously reported taxa, the phosphatized biota also include indeterminate spheroids, fused clusters of Protohertzina siciformis Missarzhevsky, 1973, the enigmatic rodlike fossil Zhejiangorhabdion comptum Yue and Zhao, 1993, phosphatized fossils, including Paradoxiconus typicalis Qian et al., 2001, protoconularid Carinachites sp., and phosphatic tubes assigned to Hyolithellus cf. H. isiticus Missarzhevsky, 1969, cf. Pseudorthotheca sp., and ?Rugatotheca sp.

The traces of macroboring organisms are known throughout the Phanerozoic, with diversification and exploitation of the macroboring niche paralleling variations in the development of skeletal metazoa. The oldest macroboring biota is an abundant yet low diversity fauna in hardgrounds and reefs of Lower Cambrian age. Following the extinction of archaeocyathids at the end of the Lower Cambrian (and thus the demise of skeletal reefs until the Middle Ordovician), boring organisms appear to be restricted to submarine hardgrounds. With the development of skeletal reefs in the Middle Ordovician the macroboring fauna shows a rapid speciation and a dramatic increase in diversity. This same pattern occurs again in the Devonian. This record appears to represent refuge of the fauna in low stress, hardground environments when skeletal reefs were not present and radiation in the high stress environment of the reef when large skeletal metazoa were abundant and diverse.

The ex situ lift out (EXLO) adhesion forces are reviewed and new applications of EXLO for focused ion beam (FIB)-prepared specimens are described. EXLO is used to manipulate electron transparent specimens on microelectromechanical systems carrier devices designed for in situ electron microscope analysis. A new patented grid design without a support film is described for EXLO. This new slotted grid design provides a surface for holding the specimen in place and also allows for post lift out processing. Specimens may be easily manipulated into a backside orientation to reduce FIB curtaining artifacts with this slotted grid. Large EXLO specimens can be manipulated from Xe+ plasma FIB prepared specimens. Finally, applications of EXLO and manipulation of FIB specimens using a vacuum probe lift out method are shown. The vacuum probe provides more control for placing specimens on the new slotted grids and also allows for easy manipulation into a backside configuration.

Transmission electron microscopy (TEM) based orientation mapping has been used to measure the length fraction of coherent and incoherent Σ3 grain boundaries in a series of six nanocrystalline Cu thin films with thicknesses in the range of 26–111 nm and grain sizes from 51 to 315 nm. The films were annealed at the same temperature (600 °C) for the same length of time (30 min), have random texture, and vary only in grain size and film thickness. A strong grain size dependence of Σ3 (coherent and incoherent) and coherent Σ3 boundary fraction was observed. The experimental results are quantitatively compared with three physical models for the formation of annealing twins developed for microscale materials. The experimental results for the nanoscale Cu films are found to be in good agreement with the two microscale models that explain twin formation as a growth accident process.