We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Design hackathons offer a unique research opportunity to study time-pressured collaborative design. At the same time, research on design hackathons faces unique methodological challenges, prompting the exploration of new research approaches. This paper proposes a new data-collection framework that leverages a virtual format of hackathon events and enables a deeper insight into hackathon dynamics. The framework applicability is presented through a case study of the IDEA challenge hackathon, in which different intrusive and non-intrusive data collection approaches were used.
To study the airflow, transmission, and clearance of aerosols in the clinical spaces of a hospital ward that had been used to care for patients with coronavirus disease 2019 (COVID-19) and to examine the impact of portable air cleaners on aerosol clearance.
Design:
Observational study.
Setting:
A single ward of a tertiary-care public hospital in Melbourne, Australia.
Intervention:
Glycerin-based aerosol was used as a surrogate for respiratory aerosols. The transmission of aerosols from a single patient room into corridors and a nurses’ station in the ward was measured. The rate of clearance of aerosols was measured over time from the patient room, nurses’ station and ward corridors with and without air cleaners [ie, portable high-efficiency particulate air (HEPA) filters].
Results:
Aerosols rapidly travelled from the patient room into other parts of the ward. Air cleaners were effective in increasing the clearance of aerosols from the air in clinical spaces and reducing their spread to other areas. With 2 small domestic air cleaners in a single patient room of a hospital ward, 99% of aerosols could be cleared within 5.5 minutes.
Conclusions:
Air cleaners may be useful in clinical spaces to help reduce the risk of acquisition of respiratory viruses that are transmitted via aerosols. They are easy to deploy and are likely to be cost-effective in a variety of healthcare settings.
Despite a growing understanding of disorders of consciousness following severe brain injury, the association between long-term impairment of consciousness, spontaneous brain oscillations, and underlying subcortical damage, and the ability of such information to aid patient diagnosis, remains incomplete.
Methods
Cross-sectional observational sample of 116 patients with a disorder of consciousness secondary to brain injury, collected prospectively at a tertiary center between 2011 and 2013. Multimodal analyses relating clinical measures of impairment, electroencephalographic measures of spontaneous brain activity, and magnetic resonance imaging data of subcortical atrophy were conducted in 2018.
Results
In the final analyzed sample of 61 patients, systematic associations were found between electroencephalographic power spectra and subcortical damage. Specifically, the ratio of beta-to-delta relative power was negatively associated with greater atrophy in regions of the bilateral thalamus and globus pallidus (both left > right) previously shown to be preferentially atrophied in chronic disorders of consciousness. Power spectrum total density was also negatively associated with widespread atrophy in regions of the left globus pallidus, right caudate, and in the brainstem. Furthermore, we showed that the combination of demographics, encephalographic, and imaging data in an analytic framework can be employed to aid behavioral diagnosis.
Conclusions
These results ground, for the first time, electroencephalographic presentation detected with routine clinical techniques in the underlying brain pathology of disorders of consciousness and demonstrate how multimodal combination of clinical, electroencephalographic, and imaging data can be employed in potentially mitigating the high rates of misdiagnosis typical of this patient cohort.
Opioid use disorder is a major public health crisis, and evidence suggests ways of better serving patients who live with opioid use disorder in the emergency department (ED). A multi-disciplinary team developed a quality improvement project to implement this evidence.
Methods
The intervention was developed by an expert working group consisting of specialists and stakeholders. The group set goals of increasing prescribing of buprenorphine/naloxone and providing next day walk-in referrals to opioid use disorder treatment clinics. From May to September 2018, three Alberta ED sites and three opioid use disorder treatment clinics worked together to trial the intervention. We used administrative data to track the number of ED visits where patients were given buprenorphine/naloxone. Monthly ED prescribing rates before and after the intervention were considered and compared with eight nonintervention sites. We considered whether patients continued to fill opioid agonist treatment prescriptions at 30, 60, and 90 days after their index ED visit to measure continuity in treatment.
Results
The intervention sites increased their prescribing of buprenorphine/naloxone during the intervention period and prescribed more buprenorphine/naloxone than the controls. Thirty-five of 47 patients (74.4%) discharged from the ED with buprenorphine/naloxone continued to fill opioid agonist treatment prescriptions 30 days and 60 days after their index ED visit. Thirty-four patients (72.3%) filled prescriptions at 90 days.
Conclusions
Emergency clinicians can effectively initiate patients on buprenorphine/naloxone when supports for this standardized evidence-based care are in place within their practice setting and timely follow-up in community is available.
Pulsatile rough-wall turbulent pipe flow is compared against its non-pulsatile counterpart using data obtained from direct numerical simulation. Results are presented at a mean friction Reynolds number of 540 for a set of three geometrically scaled roughness topographies at a single forcing condition, which, based on existing classifications, falls into the current-dominated very-high-frequency regime. By comparing the pulsatile data against an equivalent non-pulsatile dataset (Chan et al., J. Fluid Mech., vol. 854, 2018, pp. 5–33), the key differences (and similarities) between the forced and unforced configurations are identified. A major finding of this study is that the flow in the outer region retains its self-similar functional form under pulsatile rough-wall conditions, and, as a result, Townsend’s outer-layer similarity hypothesis holds for the roughness-forcing combinations considered here. On the other hand, the unsteady cases exhibit a rich array of flow physics in the region beneath the roughness crests not observed in the steady case. These differences are examined using a Moody chart, which encapsulates how the hydraulic properties of pulsatile rough-wall pipe flow differ from their non-pulsatile counterpart.
Over the past decade, emotion dysregulation has become a very popular term in the psychiatric and clinical psychology literature and it has been described as a key component in a range of mental disorders. For this reason, it has been recently called the “hallmark of psychopathology” (Beauchaine et al., 2007). However, many issues make this concept controversial.
Objectives
To explore emotion dysregulation, focusing on problems related to its definition, meanings and role in many psychiatric disorders.
Aims
To clarify the psychopathological core of emotion dysregulation and to discuss potential implications for clinical practice.
Methods
A literature review was carried out by examining articles published in English between January 2003 and June 2015. A search of the databases PubMed, PsycINFO, Science Direct, Medline, EMBASE and Google Scholar was performed to identify the relevant papers.
Results
Although, there is no agreement about the definition of emotion dysregulation, the following five overlapping, not mutually exclusive dimensions were identified: decreased emotional awareness, inadequate emotional reactivity, intense experience and expression of emotions, emotional rigidity and cognitive reappraisal difficulty. These dimensions characterise a number of psychiatric disorders in different proportions, with borderline personality disorder and eating disorders seemingly more affected than other conditions.
Conclusions
This review highlights a discrepancy between the widespread clinical use of emotion dysregulation and inadequate conceptual status of this construct. Better understanding of the various dimensions of emotion dysregulation has implications for treatment. Future research needs to address emotion dysregulation in all its multifaceted complexity.
Disclosure of interest
The authors have not supplied their declaration of competing interest.
A statistical description of flow regions with negative streamwise velocity is provided based on simulations of turbulent plane channels in the Reynolds number range $547\leqslant Re_{\unicode[STIX]{x1D70F}}\leqslant 2003$. It is found that regions of backflow are attached and their density per surface area – in wall units – is an increasing function of $Re_{\unicode[STIX]{x1D70F}}$. Their size distribution along the three coordinates reveals that, even though in the mean they appear to be circular in the wall-parallel plane, they tend to become more elongated in the spanwise direction after reaching a certain height. Time-tracking of backflow regions in a $Re_{\unicode[STIX]{x1D70F}}=934$ simulation showed they convect downstream at the mean velocity corresponding to $y^{+}\approx 12$, they seldom interact with other backflow events, their statistical signature extends in the streamwise direction for at least $300$ wall units, and they result from a complex interaction between regions of high and low spanwise vorticity far beyond the viscous sublayer. This could explain why some statistical aspects of these near-wall events do not scale in viscous units; they are dependent on the $Re_{\unicode[STIX]{x1D70F}}$-dependent dynamics further away from the wall.
Streamwise velocity and wall-shear stress are acquired simultaneously with a hot-wire and an array of azimuthal/spanwise-spaced skin friction sensors in large-scale pipe and boundary layer flow facilities at high Reynolds numbers. These allow for a correlation analysis on a per-scale basis between the velocity and reference skin friction signals to reveal which velocity-based turbulent motions are stochastically coherent with turbulent skin friction. In the logarithmic region, the wall-attached structures in both the pipe and boundary layers show evidence of self-similarity, and the range of scales over which the self-similarity is observed decreases with an increasing azimuthal/spanwise offset between the velocity and the reference skin friction signals. The present empirical observations support the existence of a self-similar range of wall-attached turbulence, which in turn are used to extend the model of Baars et al. (J. Fluid Mech., vol. 823, p. R2) to include the azimuthal/spanwise trends. Furthermore, the region where the self-similarity is observed correspond with the wall height where the mean momentum equation formally admits a self-similar invariant form, and simultaneously where the mean and variance profiles of the streamwise velocity exhibit logarithmic dependence. The experimental observations suggest that the self-similar wall-attached structures follow an aspect ratio of $7:1:1$ in the streamwise, spanwise and wall-normal directions, respectively.
This study presents findings from a first-of-its-kind measurement campaign that includes simultaneous measurements of the full velocity and vorticity vectors in both pipe and boundary layer flows under matched spatial resolution and Reynolds number conditions. Comparison of canonical turbulent flows offers insight into the role(s) played by features that are unique to one or the other. Pipe and zero pressure gradient boundary layer flows are often compared with the goal of elucidating the roles of geometry and a free boundary condition on turbulent wall flows. Prior experimental efforts towards this end have focused primarily on the streamwise component of velocity, while direct numerical simulations are at relatively low Reynolds numbers. In contrast, this study presents experimental measurements of all three components of both velocity and vorticity for friction Reynolds numbers $Re_{\unicode[STIX]{x1D70F}}$ ranging from 5000 to 10 000. Differences in the two transverse Reynolds normal stresses are shown to exist throughout the log layer and wake layer at Reynolds numbers that exceed those of existing numerical data sets. The turbulence enstrophy profiles are also shown to exhibit differences spanning from the outer edge of the log layer to the outer flow boundary. Skewness and kurtosis profiles of the velocity and vorticity components imply the existence of a ‘quiescent core’ in pipe flow, as described by Kwon et al. (J. Fluid Mech., vol. 751, 2014, pp. 228–254) for channel flow at lower $Re_{\unicode[STIX]{x1D70F}}$, and characterize the extent of its influence in the pipe. Observed differences between statistical profiles of velocity and vorticity are then discussed in the context of a structural difference between free-stream intermittency in the boundary layer and ‘quiescent core’ intermittency in the pipe that is detectable to wall distances as small as 5 % of the layer thickness.
The use of different methodological approaches together with an exhaustive qualitative study has helped to recognize important morphological traits to distinguish species in a systematic and phylogenetic framework. Parabolinella triarthroides Harrington, 1938 was described based on two cranidia from the Quebrada de Coquena, Purmamarca, Jujuy province. The generic assignment of P. triarthroides has been questioned by a phylogenetic analysis, which resolves this species as the sister group of Bienvillia Clark, 1924. To explore the generic assignment of this species, a revision of the type material, plus a morphometric analysis including specimens of Parabolinella Brøgger, 1882 and Bienvillia were performed. In addition, the original matrix used in the published phylogeny was reviewed and enlarged, including more species of Bienvillia. Continuous characters were coded in different ways in order to compare how they could affect the ordering of specimens and their phylogenetic relationships. Finally, both methodologies were compared, especially in regard to the behavior of the quantitative characters included in the analyses. From the combined analyses, it is shown that similarities between the cranidium of P. triarthroides and all other Parabolinella species are true homologies instead of a by-product of evolutionary convergence. Therefore, P. triarthroides should be considered a member of this genus. Finally, this study demonstrates that the best strategy for solving systematic problems in groups where the morphological variation is the only source of information (i.e., fossil taxa without living representatives) is the implementation of an integrative approach, combining different methodological techniques and a good description of specimens.
The late Cambrian-Early Ordovician sequences of the Cordillera Oriental in northwestern Argentina are extensive and highly fossiliferous. The olenid trilobite Parabolinella argentinensis Kobayashi sensu Harrington and Leanza, 1957 was reported from a great number of Tremadocian localities and includes a wide range of morphologies. Based on specimens collected from the type locality (Purmamarca, Jujuy) and the quebrada Moya (Huacalera, Jujuy), as well as on material of the Harrington and Leanza collections in the University of Buenos Aires, classic morphometry and geometric morphometry methods were used to evaluate the variability in the cranidium of P. argentinensis. The results obtained from the two methodologies are similar. Both analyses allowed the review of the diagnosis of P. argentinensis, and the distinction of two new morphologies: Parabolinella clarisae n. sp. and Parabolinella pompadouris n. sp. The results show how morphogeometrics distinguishes more clearly the three morphotypes and provides graphical representations of the differences between those groups and how from the representations plus the correlation between classical variables and principal components, new diagnostic characters that distinguish the three morphospecies, can be identified.
In the analysis of velocity fields in turbulent boundary layers, the traditional Reynolds decomposition is universally employed to calculate the fluctuating component of streamwise velocity. Here, we demonstrate the perils of such a determination of the fluctuating velocity in the context of structural analysis of turbulence when applied in the outer region where the flow is intermittently turbulent at a given wall distance. A new decomposition is postulated that ensures non-turbulent regions in the flow do not contaminate the fluctuating velocity components in the turbulent regions. Through this new decomposition, some of the typical statistics concerning the scale and structure of turbulent boundary layers are revisited.
The identification of uniform momentum zones in wall-turbulence, introduced by Adrian, Meinhart & Tomkins (J. Fluid Mech., vol. 422, 2000, pp. 1–54) has been applied to turbulent channel flow, revealing a large ‘core’ region having high and uniform velocity magnitude. Examination of the core reveals that it is a region of relatively weak turbulence levels. For channel flow in the range $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}Re_{\tau } = 1000\text {--}4000$, it was found that the ‘core’ is identifiable by regions bounded by the continuous isocontour lines of the streamwise velocity at $0.95U_{CL}$ (95 % of the centreline velocity). A detailed investigation into the properties of the core has revealed it has a large-scale oscillation which is predominantly anti-symmetric with respect to the channel centreline as it moves through the channel, and there is a distinct jump in turbulence statistics as the core boundary is crossed. It is concluded that the edge of the core demarcates a shear layer of relatively intense vorticity such that the interior of the core contains weakly varying, very low-level turbulence (relative to the flow closer to the wall). Although channel flows are generally referred to as ‘fully turbulent’, these findings suggest there exists a relatively large and ‘quiescent’ core region with a boundary qualitatively similar to the turbulent/non-turbulent interface of boundary layers, jets and wakes.
This article reports on one component of a larger study on measurement of the zero-pressure-gradient turbulent flat plate boundary layer, in which a detailed investigation was conducted of the suite of corrections required for mean velocity measurements performed using Pitot tubes. In particular, the corrections for velocity shear across the tube and for blockage effects which occur when the tube is in close proximity to the wall were investigated using measurements from Pitot tubes of five different diameters, in two different facilities, and at five different Reynolds numbers ranging from ${\mathit{Re}}_{\theta } = 11\hspace{0.167em} 100$ to 67 000. Only small differences were found amongst commonly used corrections for velocity shear, but improvements were found for existing near-wall proximity corrections. Corrections for the nonlinear averaging of the velocity fluctuations were also investigated, and the results compared to hot-wire data taken as part of the same measurement campaign. The streamwise turbulence-intensity correction was found to be of comparable magnitude to that of the shear correction, and found to bring the hot-wire and Pitot results into closer agreement when applied to the data, along with the other corrections discussed and refined here.
In this study, we present cytogenetic data regarding 66 Myzus persicae strains collected in different regions of Italy. Together with the most common 2n = 12 karyotype, the results showed different chromosomal rearrangements: 2n = 12 with A1–3 reciprocal translocation, 2n = 13 with A1–3 reciprocal translocation and A3 fission, 2n = 13 with A3 fission, 2n = 13 with A4 fission, 2n = 14 with X and A3 fissions. A 2n = 12–13 chromosomal mosaicism has also been observed. Chromosomal aberrations (and in particular all strains showing A1–3 reciprocal translocation) are especially frequent in strains collected on tobacco plants, and we suggest that a clastogenic effect of nicotine, further benefited by the holocentric nature of aphid chromosomes, could be at the basis of the observed phenomenon.
Data comparing age-related alterations in faecal IgA concentrations of dogs are not available in the literature. The present study aimed to compare the faecal concentrations of IgA in puppies, mature and senior dogs. A total of twenty-four beagle dogs were used, including eight puppies (5 months old, four females and four males), eight mature (4·6 years old, eight males) and eight senior dogs (10·6 years old, three males and five females). Fresh faecal samples were collected from each dog for three consecutive days and pooled by animal. After saline extraction, IgA content was measured by ELISA. Data were analysed by one-way ANOVA, and means were compared with Tukey's test (P < 0·05). Results showed that puppies have lower faecal IgA concentrations than mature dogs (P < 0·05); senior animals presented intermediary results. The reduced faecal IgA concentration in puppies is consistent with the reduced serum and salivary IgA concentrations reported previously, suggesting a reduced mucosal immunity in this age group. Although some studies have found an increased serum IgA concentration in older dogs, this may differ from the intestinal secretion of IgA, which appears to be lower in some senior animals (four of the eight dogs studied).
A correction for streamwise Reynolds stress data acquired with insufficient spatial resolution is proposed for wall-bounded flows. The method is based on the attached eddy hypothesis to account for spatial filtering effects at all wall-normal positions. This analysis reveals that outside the near-wall region the spatial filtering effect scales inversely with the distance from the wall, in contrast to the commonly assumed scaling with the viscous length scale. The new formulation is shown to work very well for data taken over a wide range of Reynolds numbers and wire lengths.
Sleep disorders cause considerable morbidity and distress in the aging population. By highlighting the clinical diagnosis and management of sleep disorders, this volume provides a valuable resource for all those involved in health care of older individuals. The changes in sleep patterns that occur during normal aging are described, followed by authoritative chapters on the presentation of various age-related sleep disorders. The book deals with the range of therapeutic measures available for managing these disorders and gives insight to potential areas of research that have emerged in the last few years, such as the study of circadian rhythms in later life, sleep patterns associated with co-morbidities and the use of quality-of-life measurement tools to determine sleep quality as we age. This volume is relevant to sleep disorders specialists, psychiatrists, geriatricians and gerontologists, and any professionals and researchers working in the interdisciplinary areas of sleep and aging.