Evaluation of benefits beyond quantitative academic outputs is essential in determining translational research value. We used the Translational Science Benefits Model (TSBM) to examine the impact of the QUARTET USA trial using 30 benefits across 4 domains: Clinical, Community, Economic, and Policy. We found that the QUARTET USA trial demonstrated impact in six areas within the Clinical, and Community domains and had potential impact in two additional areas within the Community and Economic domains. Use of the TSBM supports the value of the QUARTET USA trial, which can be used as a template for future cardiovascular trials.

Background: A clear understanding of the neuropathological causes of RPD is needed to inform the diagnosis and treatment of patients with rapidly progressive dementia (RPD). Methods: Patients with <4.0 years from symptom onset to death were identified within the Mayo Clinic Neurodegenerative Brain Bank (1998-2020). Relevant clinical details were extracted from available records. Neuropathological diagnoses were assigned following standard protocols. Results: 310/8586 (3.6%) cases met RPD criteria. Relative to typically progressive cases, prion disease most commonly presented as RPD (74%, 32/43), followed by progressive supranuclear palsy/corticobasal degeneration (PSP/CBD: 7.5%, 142/1894), other frontotemporal lobar degeneration (FTLD: 5.7%, 32/561), Lewy body disease (LBD: 4.1%, 49/1202), and Alzheimer disease (AD: 1.8%, 48/2687). Average age-at-symptom onset was 69.5±10.4 years. Average disease duration was 2.9±1.0 years. Prion diseases had the most rapid disease course (1.6±1.3 years). Comorbid cerebrovascular disease (25.5%), and clinically symptomatic depression (41.3%), psychoses (37.1%), and sleep disturbances (39.4%) were common across groups. Only psychosis was associated with shorter disease duration (β=-0.31 years, CI95% -0.53, -0.082, controlling for age-at-symptomatic onset). Conclusions: Although prion disease commonly presented as RPD, atypical presentations of more prevalent neurodegenerative diseases accounted for most cases of RPD. Rapidly progressive variants of typical neurodegenerative diseases warrant consideration in clinical practice.

Background: Accurate etiologic diagnoses are needed in patients with rapidly progressive dementia (RPD) to ensure access to symptomatic and disease-modifying therapies when available. Methods: Patients with RPD were prospectively enrolled and evaluated at Washington University (Saint Louis, MO; 2016-2019) and Mayo Clinic (Jacksonville, FL; 2020-2021). Etiologic diagnoses were independently assigned by two dementia specialists integrating clinical features and the results of diagnostic tests; disagreements were resolved via blinded review by a third specialist. Results: 160 RPD patients were enrolled and followed. Average age-at-symptom onset was 60.0±15.9 years; 50% were female. Inter-rater reliability (91% agreement; Cohen’s κ=0.88, p<0.001) and clinicopathologic correlation were excellent (100% agreement in 24 patients with neuropathologic data). Autoimmune encephalitis was the leading cause of RPD (39%), followed by Alzheimer disease and related dementias (29%), Creutzfeldt-Jakob disease (15%), and other causes (15%). Patients with potentially treatable causes of RPD were younger (54.5±18.2 than those with neurodegenerative causes (67.3±9.5; p<0.001), and more likely to present with altered levels of consciousness, seizures, or CSF pleocytosis (p<0.05). Conclusions: Etiologic diagnoses can be reliably established in RPD patients using available clinical data. The prevalence of autoimmune encephalitis in this series justifies routine screening for potentially treatment-responsive causes of RPD, particularly in younger patients.

Background: Assays capable of detecting prions in CSF (e.g., RT-QuIC) have greatly improved the antemortem diagnosis of Creutzfeldt-Jakob disease (CJD) yet take time to conduct and are not widely accessible. There is a need to identify clinical features and common tests that identify mimics at presentation. Methods: Mimics were identified within longitudinal studies of rapidly progressive dementia at study sites. Mimics met clinical criteria for probable CJD but did not have CJD. Clinical features were compared between mimics and patients with CJD assessed at Mayo Clinic Enterprise (n=79) and Washington University in St. Louis (n=10; Jan-2014 to Oct-2020). Results: Mimics (10/155; 6.5%) were diagnosed with autoimmune encephalitis (n=7), neurosarcoidosis, frontotemporal lobar degeneration with motor neuron disease, and unknown dementia. Age-at-symptom onset, gender, presenting symptoms, and EEG and MRI findings were similar between mimics and CJD patients. Focal motor abnormalities (49/93, 10/10), elevations in CSF leukocytosis (4/92, 5/10) and protein (39/92, 9/10) were more common in mimics (p<0.01). Neural-specific autoantibodies associated with autoimmune encephalitis were detected within the serum (4/9) and CSF (5/10) of mimics, but not CJD cases. Conclusions: Autoimmune encephalitis, neurosarcoidosis and neurodegenerative diseases may mimic CJD at presentation and should be considered in patients with early motor dysfunction and abnormal CSF studies.

Two samples collected from the phosphogypsum deposits of the chemical products industry Elixir Prahovo (Serbia) were subjected to a recrystallization experiment performed over several repeated cycles. In these tests, phosphogypsum was separated into recrystallized (purified) gypsum, insoluble residue and supernatant. Both raw phosphogypsum and recrystallized gypsum were examined using inductively coupled plasma optical emission spectrometry, X-ray diffraction and scanning electron microscopy with energy-dispersive spectrometry. The activity concentrations of 238U, 235U, 226Ra, 210Pb, 232Th and 40K were investigated using γ-ray spectrometry. Based on the activity concentration results, a number of radiometric parameters were calculated for the original and recrystallized phosphogypsum (i.e. radium equivalent activity, γ indices for construction materials, α index and external and internal hazard indices). Raw phosphogypsum samples showed greater mean activity concentration levels of 238U and 226Ra than the international recommended limits, while the recrystallized gypsum demonstrated notably lower activity concentrations for these two isotopes. The activity concentration of 226Ra in recrystallized gypsum is ~6 times lower than in raw phosphogypsum. Therefore, recrystallized gypsum does not present a radiation hazard when used as a building material, while raw phosphogypsum meets the requirements only for road construction materials.

Stuttering, as a communication disorder, is a field of great interest, with many hypothesis regarding its nature and appropriate treatment. Many studies tried to emphasize the bond between stuttering and anxiety. Frequently, stuttering is associated with strong emotional reaction, as anxiety, emphasized by negative consequences of “not being able to talk accurately”. This turns in avoidance of speak and social problems as school difficulties.

The aim of this study is anxiety evaluation in children with stuttering through specialized psychological intervention.

We applied MASC (Multidimensional Anxiety Scale for Children) and CDI (Child Depression Inventory) to 20 children diagnosed with stuttering, aged 6–16, from Cluj -Napoca, both at the beginning and at the end of the study. Psychological intervention consisted of two evaluation sessions (one with the parent and one with the child) and ten group sessions (psychodrama and cognitive-behavioral techniques).

The results showed a significant decrease of anxiety (p < 0.05), and no difference in depression symptoms (for statistical data we used SPSS 16.0 Program).

4H-SiC p+n photodiodes based on ultrathin-junctions have been fabricated with distinct processes for the p+-region creation: either with Aluminium conventional ion implantation, or with Boron Plasma Ion Immersion Implantation. Spectral sensitivity measurements were performed at several temperatures from room temperature up to 340°C, with incident wavelengths ranging from 200 to 400 nm. Both responses are characterized by a stability between 200 and 270 nm, and a important increase with temperature between 270 and 380 nm. This fact has to be related to the two different kinds of optical absorption phenomena in SiC with respect to the wavelength, which are direct and indirect (phonon assisted) transitions. When decreasing the temperature, we noticed a hysteresis effect, which could be due to charge trapping by temperature activated defects. After strong proton and electron irradiations, the diodes showed a stability of the response below 270 nm, making them suitable for use in harsh environments. Simulation was performed at room temperature, with a good correlation between simulated and experimental room temperature curves.

Large-scale laboratory experiments were performed on the Coriolis rotating platform to study the stability of intense vortices in a thin stratified layer. A linear salt stratification was set in the upper layer on top of a thick barotropic layer, and a cylinder was towed in the upper layer to produce shallow cyclones and anticyclones of similar size and intensity. We focus our investigations on submesoscale eddies, where the radius is smaller than the baroclinic deformation radius. Towing speed, cylinder size and stratification were changed in order to cover a large range of the parameter space, staying in a relatively high horizontal Reynolds number ($Re= 2000{{\unicode{x2013}}}7000$). The Rayleigh criterion states that inertial instabilities should strongly destabilize intense anticyclonic eddies if the vorticity in the vortex core is negative enough ${\zeta }_{0} / f\lt - 1$, where ${\zeta }_{0} $ is the relative vorticity in the core of the vortex, and $f$ is the Coriolis parameter. However, we found that some anticyclones remain stable even for very intense negative vorticity values, up to ${\zeta }_{0} / f= - 3. 5$, when the Burger number is large enough. This is in agreement with the linear stability analysis performed in part 1 (J. Fluid Mech., vol. 732, 2013, pp. 457–484), which shows that the combined effect of a strong stratification and a moderate vertical dissipation may stabilize even very intense anticyclones, and the unstable eddies we found were located close to the marginal stability limit. Hence, these experimental results agree well with the simple stability diagram proposed in the Rossby, Burger and Ekman parameter space for inertial destabilization of viscous anticyclones within a shallow and stratified layer.

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009