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1 results

  • A Twin Study of Human Red Blood Cell Catechol-O-Methyl Transferase

  • Leon Grunhaus, Richard Ebstein, Robert H. Belmaker, S. Gerald Sandler, Wulff Jonas
  • Journal:
    The British Journal of Psychiatry / Volume 128 / Issue 5 / May 1976
    Published online by Cambridge University Press:
    29 January 2018, pp. 494-498
    Print publication:
    May 1976

  • Significant sibling-sibling and within-family correlations of human red blood cell catechol-o-methyl transferase activity have suggested a high degree of genetic control over levels of activity of this catecholamine-related enzyme. However, family studies do not disentangle genetic from environmental similarities as causative of within-family correlations. We therefore undertook a human twin study using the monozygotic-dizygotic comparison method. Twelve pairs of monozygotic twins had an intraclass correlation of .90 in red blood cell catechol-o-methyl transferase activity, and seven pairs of dizygotic twins had an intraclass correlation of .37. Heritability of the enzyme activity was estimated by different methods as between 68–100 per cent.