Avolition affects quality of life in chronic schizophrenia. We investigated
the effect of modafinil upon unconstrained motor activity in 18 male
patients. In a randomised crossover design study wrist-worn actigraphic
monitors were used to objectively record motor activity over a 20 h period.
Patients' total activity was significantly greater when given the drug.
These data suggest that modafinil increases quantifiable motor behaviour in
schizophrenia and may have an impact on avolition.