A survey was conducted among Canadian tertiary neonatal intensive care units. Of the 27 sites who responded, 9 did not have any form of antimicrobial stewardship, and 11 used vancomycin for empirical coverage in late-onset-sepsis evaluations. We detected significant variations in the diagnostic criteria for urinary tract infection and ventilator-associated pneumonia.

Correcting a sign error results in no changes to the key conclusions of Hutchings and others (2011). However, there is an improved agreement with previous work. Mean total sea-ice deformation scales log linearly with distance and the scaling exponent was found to be dependent on time. We find a linear relationship between the temporal scale and spatial scaling exponent, for timescales of an hour to a day. Extrapolating to the timescales of deformation resolved by RADARSAT, we find total deformation and distance scale with an exponent of between −0.16 and −0.19.

In late March 2007 an array of GPS ice drifters was deployed in the Beaufort Sea as part of the Sea Ice Experiment: Dynamic Nature of the Arctic (SEDNA). the drifters were deployed in an array designed to resolve four, nested spatial scales of sea-ice deformation, from 10 to 140 km, with the arrays maintaining appropriate shape for strain-rate calculation until mid-June. In this paper, we test whether sea-ice deformation displays fractal properties in the vicinity of SEDNA. We identify that deformation time series have different spectral properties depending on the spatial scale. At the scales around 100 km, deformation is a red-noise process, indicating the importance of the ice-pack surface forcing in determining the deformation rate of sea ice at this scale. At smaller scales, the deformation becomes an increasingly whiter process (it has pink noise properties), which suggests an increasing role of dissipative processes at smaller scales. At spatial scales of 10–100 km, and sub-daily scales, there is no deformation coherence across scales; coherence only becomes apparent at longer scales greater than 100 km. the lack of coherence at small scales aids in understanding previous observations where correlation between 10km regions adjacent to each other varied widely, with correlation coefficients between –0.3 and 1. This suggests it is not appropriate to think of sea ice as having a decorrelation length scale for deformation. We find that lead scale observations of deformation are required when estimating ice growth in leads and ridging time series. For the two SEDNA arrays, we find coherence between 140 and 20 km scale deformation up to periods of 16 days. This suggests sea-ice deformation displays coherent deformation between 100 km scale and the scale of the Beaufort Sea (of order 1000 km), over synoptic time periods (daily to weekly timescales). Organization of leads at synoptic and larger scales is an emergent feature of the deformation field that is caused by the smooth variation of surface forcing (wind) on the ice pack.

Protein fermentation end products may damage the colonic mucosa, which could be counteracted by dietary inclusion of fermentable carbohydrates (fCHO). Although fermentable crude protein (fCP) and fCHO are known to affect microbial ecology, their interactive effects on epithelial barrier function are unknown. In the present study, in a 2 × 2 factorial experiment, thirty-two weaned piglets were fed low-fCP/low-fCHO (14·5 % crude protein (CP)/14·5 % total dietary fibre (TDF)), low-fCP/high-fCHO (14·8 % CP/16·6 % TDF), high-fCP/low-fCHO (19·8 % CP/14·5 % TDF) and high-fCP/high-fCHO (20·1 % CP/18·0 % TDF) diets. After 21–23 d, samples of proximal and distal colonic mucosae were investigated in Ussing chambers with respect to the paracellular and transcytotic passages of macromolecules and epithelial ion transport. The high-fCHO diets were found to reduce the permeability of the distal colon to the transcytotic marker horseradish peroxidase (HRP, 44 kDa; P <0·05) and also reduce the paracellular permeation of N-hydroxysuccinimide-biotin into the submucosa (443 Da; P <0·05), whereas that of HRP was decreased by the high-fCP diets (P <0·01). Short-circuit current (active ion transport), transepithelial resistance (barrier function) and charge selectivity were largely unaffected in both the segments. However, the high-fCP diets were found to suppress the aldosterone-induced epithelial Na channel activity (P <0·01) irrespective of fCHO inclusion. The high-fCP diets generally reduced the expression of colonic claudin-1, claudin-2 and claudin-3 (P <0·01), while that of claudin-4 was increased by the high-fCHO diets (P <0·01). The high-fCHO diets also altered the ratio between occludin forms (P <0·05) and increased the expression of tricellulin in the proximal colon, which was not observed with high-fCP diets. In conclusion, dietary fCHO and fCP exerted few and largely independent effects on functional measurements, but altered tight junction protein composition in a compensatory way, so that colonic transport and barrier properties were only marginally affected.

An overview about the German cluster project Cool Silicon aiming at increasing the energy efficiency for semiconductors, communications, sensors and software is presented. Examples for achievements are: 1000 times reduced gate leakage in transistors using high-fc (HKMG) materials compared to conventional poly-gate (SiON) devices at the same technology node; 700 V transistors integrated in standard 0.35 μm CMOS; solar cell efficiencies above 19% at < 200 W/m2 irradiation; 0.99 power factor, 87% efficiency and 0.088 distortion factor for dc supplies; 1 ns synchronization resolution via Ethernet; database accelerators allowing 85% energy savings for servers; adaptive software yielding energy reduction of 73% for e-Commerce applications; processors and corresponding data links with 40% and 70% energy savings, respectively, by adaption of clock frequency and supply voltage in less than 20 ns; clock generator chip with tunable frequency from 83-666 MHz and 0.62-1.6 mW dc power; 90 Gb/s on-chip link over 6 mm and efficiency of 174 fJ/mm; dynamic biasing system doubling efficiency in power amplifiers; 60 GHz BiCMOS frontends with dc power to bandwidth ratio of 0.17 mW/MHz; driver assistance systems reducing energy consumption by 10% in cars

We introduce a technique to permit x-ray absorption spectroscopy studies focusing on individual phase-change (Ge2Sb2Te5) memory cells in fully integrated PC-RAM structures. Devices were investigated employing an x-ray nanobeam of only about 300 nm diameter, which could be fully contained within the spatial extent of the active area within a single device cell and enabled us to investigate individual devices without interference from non-switching material surrounding the area of interest. By monitoring the fluorescence signals of tungsten and germanium at a photon energy corresponding to the Ge K-edge absorption edge white line position, we were successful in producing 2D area maps of the active cell region, which clearly show the imbedded tungsten heater element and the switched region of the phase change material. Additionally, position dependent changes in the phase change material could be traced by taking an array of XANES spectra at the Ge K-edge on and in the vicinity of individual devices.