Oxycalciomicrolite (IMA2019-110), (Ca,Na)2(Ta,Nb,Ti)2O6(O,F), is a new member of microlite-group mineral found in the saprolite of the weathered Fumal pegmatite, located close to the city of Nazareno, Minas Gerais state, Brazil. It occurs as an accessory mineral associated with quartz, albite, microcline, muscovite, columbite-subgroup minerals, cassiterite, hematite, ilmenite, monazite-(Ce), xenotime-(Y), zircon, beryl, spinel, epidote and garnet-group minerals. Oxycalciomicrolite is found as octahedral crystals, occasionally modified to rhombododecahedra, ranging from 0.2 to 0.5 mm in size. The crystals are brownish-yellow to brownish-red and translucent, with white streak and vitreous to resinous lustre. The tenacity is brittle, with a Mohs hardness of 5–5½. Cleavage and parting are not observed; the fracture is conchoidal. Electron microprobe analysis, Raman and infrared spectroscopies and X-ray powder diffraction were applied to characterise this mineral. Oxycalciomicrolite is isotropic, ncalc. = 2.037, and the calculated density is 6.333 g/cm3. The composition is (Ca1.57□0.26Na0.06Sn0.03Sr0.03U0.02Mn0.02Fe0.01Ce0.01)∑2.00(Ta1.79Nb0.18Ti0.03)∑2.00O6.00[O0.64F0.19□0.17]∑1.00 analysed by electron microprobe using wavelength dispersive spectrometry. The unit-cell parameters obtained by Pawley fitting from powder X-ray diffraction data are a = 10.4325(4) Å and V = 1135.46(14) Å3 with Z = 8.