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1 results

  • Longitudinal MRI study in schizophrenia patients and their healthy siblings

  • Rachel G. H. Brans, Neeltje E. M. van Haren, G. Caroline M. van Baal, Wouter G. Staal, Hugo G. Schnack, René S. Kahn, Hilleke E. Hulshoff Pol
  • Journal:
    The British Journal of Psychiatry / Volume 193 / Issue 5 / November 2008
    Published online by Cambridge University Press:
    02 January 2018, pp. 422-423
    Print publication:
    November 2008
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  • To investigate whether genetic and/or disease-related factors are involved in progressive structural brain changes in schizophrenia, magnetic resonance imaging scans with a 5-year scan interval were acquired in patients, their same-gender siblings and matched healthy controls. Structural equation modelling was applied to assess disease and familial effects. Whole brain and cerebral grey matter volumes decreased excessively in patients compared with their siblings and the controls, suggesting that the progressive brain loss in schizophrenia may be related to the disease process.