The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.

In stably stratified flow over a three-dimensional hill, we can define a dividing streamline that separates those streamlines that pass around the hill from those that pass over the hill. The height Hs of this dividing streamline can be estimated by Sheppard's simple energy argument; fluid parcels originating far upstream of a hill at an elevation above Hs have sufficient kinetic energy to rise over the top, whereas those below Hs must pass around the sides. This prediction provides the basis for analysing an extensive range of laboratory observations and measurements of stably stratified flow over a variety of shapes and orientations of hills and with different upwind density and velocity profiles. For symmetric hills and small upwind shear, Sheppard's expression provides a good estimate for Hs. For highly asymmetric flow and/or in the presence of strong upwind shear, the expression provides a lower limit for Hs. As the hills become more nearly two-dimensional, these experiments become less well defined because steady-state conditions take progressively longer to be established. The results of new studies are presented here of the development of the unsteady flow upwind of two-dimensional hills in a finite-length towing tank. These measurements suggest that a very long tank would be required for steady-state conditions to be established upstream of long ridges with or without small gaps and cast doubt upon the validity of previous laboratory studies.

Studies of rare Mendelian disorders of low density lipoprotein cholesterol (LDL-C) metabolism have identified specific genetic mutations in the LDL receptor and apolipoprotein B. Although these rare mutations account for a small proportion of LDL-C variation, twin and adoption studies indicate that at least 50% of the overall LDL-C observed variation is genetically determined. In a heterogeneous sample of 3227 subjects from the NHLBI Family Heart Study collected from four US centres, we find evidence for a common major gene accounting for mild elevations (1.25 standard deviations) in LDL-C. The analysis favored a recessive model with a frequency of 0.52 for the gene influencing elevated LDL-C, phenotypic means of 113 mg/dl for the normal genotypes and 146 mg/dl for the abnormal genotype, and a significant polygenic heritability. This statistically-inferred major gene accounted for 24% of the variation in LDL-C, with polygenes accounting for another 28% of the variation. Using parameters for major gene transmission estimated in the segregation analysis, LDL-C showed no linkage to the LDL receptor gene (LDLR), nor to the apolipoprotein E gene (APOE), nor to the cholesterol 7α-hydroxylase gene (CYP7A1), indicating the major gene effect influencing mild elevation in LDL-C is not explained by any of these candidate loci.

The highest duty of an American diplomatic or consular officer is to protect citizens of the United States in lawful pursuit of their affairs in foreign countries. The document issued in authentication of the right to such protection is the passport.

Broadly speaking, the Department issues two kinds of passports — those for citizens and those for persons who are not citizens. Citizens’ passports are ordinary and special; aliens’ passports are for travel in the United States and for qualified protection abroad of those who have taken the first steps to become American citizens.

The citizen’s passport is the only document issued by the Department of State to authenticate the citizenship of an American going abroad. The Act of August 18, 1856, makes the issuance to one who is not a citizen a penal offense if it is committed by a consular officer. Before this law was passed the Department did not issue the document to aliens; but it was permitted to this government’s agents abroad sometimes to issue it to others than American citizens. The Personal Instructions to the Diplomatic Agents of the United States of 1853 said: