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While unobscured and radio-quiet active galactic nuclei are regularly being found at redshifts
$z > 6$
, their obscured and radio-loud counterparts remain elusive. We build upon our successful pilot study, presenting a new sample of low-frequency-selected candidate high-redshift radio galaxies (HzRGs) over a sky area 20 times larger. We have refined our selection technique, in which we select sources with curved radio spectra between 72–231 MHz from the GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) survey. In combination with the requirements that our GLEAM-selected HzRG candidates have compact radio morphologies and be undetected in near-infrared
$K_{\rm s}$
-band imaging from the Visible and Infrared Survey Telescope for Astronomy Kilo-degree Infrared Galaxy (VIKING) survey, we find 51 new candidate HzRGs over a sky area of approximately
$1200\ \mathrm{deg}^2$
. Our sample also includes two sources from the pilot study: the second-most distant radio galaxy currently known, at
$z=5.55$
, with another source potentially at
$z \sim 8$
. We present our refined selection technique and analyse the properties of the sample. We model the broadband radio spectra between 74 MHz and 9 GHz by supplementing the GLEAM data with both publicly available data and new observations from the Australia Telescope Compact Array at 5.5 and 9 GHz. In addition, deep
$K_{\rm s}$
-band imaging from the High-Acuity Widefield K-band Imager (HAWK-I) on the Very Large Telescope and from the Southern Herschel Astrophysical Terahertz Large Area Survey Regions
$K_{\rm s}$
-band Survey (SHARKS) is presented for five sources. We discuss the prospects of finding very distant radio galaxies in our sample, potentially within the epoch of reionisation at
$z \gtrsim 6.5$
.
In non-uniform stratification, horizontally propagating internal waves with the vertical structure of a single mode self-interact to excite superharmonics. Baker & Sutherland (J. Fluid Mech., vol. 891, 2020, R1) showed that a vertical mode-1 parent wave of sufficiently small amplitude dominantly excites a vertical mode-1 superharmonic with double the horizontal wavenumber. Through theory, assuming a parent wave of sufficiently small amplitude, they showed that the superharmonics grew and decayed periodically due to the parent forcing frequency being off-resonant with the natural frequency of the superharmonic. Here, we extend this theory to allow for larger parent wave amplitudes and/or stronger resonant forcing, as would occur at lower latitudes, where the influence of background rotation is small. The resulting coupled system of nonlinear ordinary differential equations is shown to well predict the evolution of the internal tide as determined in fully nonlinear numerical simulations. With strong nonlinear forcing, successive superharmonics grow to non-negligible amplitudes in what we call the ‘superharmonic cascade’. The phase relationship between the superharmonics is such that when superimposed, the internal tide transforms into a solitary wave train, consistent with the predictions of well-established shallow-water models, particularly that of the Ostrovsky equation, which is an extension of the Korteweg–de Vries equation accounting for background rotation. This work thus gives new insight into internal solitary wave generation. The model equations have less restrictive assumptions than models based upon shallow-water theory, and because they are quickly solved, these provide a potentially powerful new tool to examine the nonlinear evolution of the internal tide.
We examine Lagrangian transport by a nonlinearly evolving vertical mode-1 internal tide in non-uniform stratification. In a companion paper (Sutherland & Dhaliwal, J. Fluid Mech., 2022, in press) it was shown that a parent internal tide can excite successive superharmonics that superimpose to form a solitary wave train. Despite this transformation, here we show that the collective forcing by the parent wave and superharmonics is effectively steady in time. Thus we derive relatively simple formulae for the Stokes drift and induced Eulerian flow associated with the waves under the assumption that the parent waves and superharmonics are long compared with the fluid depth. In all cases, the Stokes drift exhibits a mixed mode-1 and mode-2 vertical structure with the flow being in the waveward direction at the surface. If the background rotation is non-negligible, the vertical structure of the induced Eulerian flow is equal and opposite to that of the Stokes drift. This flow periodically increases and decreases at the inertial frequency with maximum magnitude twice that of the Stokes drift. When superimposed with the Stokes drift, the Lagrangian flow at the surface periodically changes from positive to negative over one inertial period. If the background rotation is zero, the induced Eulerian flow evolves non-negligibly in time and space for horizontally modulated waves: the depth below the surface of the positive Lagrangian flow becomes shallower ahead of the peak of the amplitude envelope and becomes deeper in the lee of the peak. These predictions are well-captured by fully nonlinear numerical simulations.
Traditionally, primate cognition research has been conducted by independent teams on small populations of a few species. Such limited variation and small sample sizes pose problems that prevent us from reconstructing the evolutionary history of primate cognition. In this chapter, we discuss how large-scale collaboration, a research model successfully implemented in other fields, makes it possible to obtain the large and diverse datasets needed to conduct robust comparative analysis of primate cognitive abilities. We discuss the advantages and challenges of large-scale collaborations and argue for the need for more open science practices in the field. We describe these collaborative projects in psychology and primatology and introduce ManyPrimates as the first, successful collaboration that has established an infrastructure for large-scale, inclusive research in primate cognition. Considering examples of large-scale collaborations both in primatology and psychology, we conclude that this type of research model is feasible and has the potential to address otherwise unattainable questions in primate cognition.
The title of this paper proclaims its central interest—the relationship which holds between the concept of integrity and the concept of the identity of the self, or, for short, self-identity. Unreflective speech often suggests a close relationship between the two, but in the latter half of this century, notwithstanding one or two notable exceptions, they have been discussed with minimum cross-reference as if they belonged to two rather different philosophical menus which tended not to be available at the same restaurant on the same night. My intention is to argue that our account of the one carried implications for the other and that this relationship is reflexive. My argument will proceed by stating and criticizing a common account of the relationship between each of these concepts which tends to offer mutual support for the implied account of each. Thereafter an alternative account will be outlined.
Infectious mononucleosis is a relatively common acute presentation to the ENT department. There is an expected derangement in the liver function test results in most patients. There is no guidance regarding follow up, and practice varies. This study aimed to evaluate the utility of liver function tests and abdominal ultrasound in infectious mononucleosis.
Methods
This was a retrospective study of all adult patients admitted under ENT with infectious mononucleosis over a five-year period.
Results
A total of 153 patients were included; 80 per cent had abnormal liver function test results at presentation. Around 50 per cent had at least one liver function test assessment following discharge. Median (interquartile range) time to resolution of liver function test results was 32 days (20–50 days); maximum time was 10 months. Six patients had in-patient abdominal ultrasound: all showed a normal liver and biliary tree. No patient developed any liver disease sequelae.
Conclusion
The findings suggest that serial assessment of liver function is not required in immunocompetent adults with subclinical derangement in liver function.
Castration of male piglets in the United States is conducted without analgesics because no Food and Drug Administration (FDA) approved products are labeled for pain control in swine. The absence of approved products is primarily due to a wide variation in how pain is measured in suckling piglets and the lack of validated pain-specific outcomes individually indistinct from other biological responses, such as general stress or inflammation responses with cortisol. Simply put, to measure pain mitigation, measurement of pain must be specific, quantifiable, and defined. Therefore, given the need for mitigating castration pain, a consortium of researchers, veterinarians, industry, and regulatory agencies was formed to identify potential animal-based outcomes and develop a methodology, based on the known scientific research, to measure pain and the efficacy of mitigation strategies. The outcome-based measures included physiological, neuroendocrine, behavioral, and production parameters. Ultimately, this consortium aims to provide a validated multimodal methodology to demonstrate analgesic drug efficacy for piglet castration.
Measurable outcomes were selected based on published studies suggesting their validity, reliability, and sensitivity for the direct or indirect measurement of pain associated with surgical castration in piglets. Outcomes to be considered are observation of pain behaviors (i.e. ethogram defined behaviors and piglet grimace scale), gait parameters measured with a pressure mat, infrared thermography of skin temperature of the cranium and periphery of the eye, and blood biomarkers. Other measures include body weight and mortality rate.
This standardized measurement of the outcome variable's primary goal is to facilitate consistency and rigor by developing a research methodology utilizing endpoints that are well-defined and reliably measure pain in piglets. The resulting methodology will facilitate and guide the evaluation of the effectiveness of comprehensive analgesic interventions for 3- to 5-day-old piglets following surgical castration.
Most patients with World Federation of Neurological Surgeons (WFNS) grade 5 subarachnoid hemorrhage (SAH) have poor outcomes. Accurate assessment of prognosis is important for treatment decisions and conversations with families regarding goals of care. Unjustified pessimism may lead to “self-fulfilling prophecy,” where withdrawal of life-sustaining measures (WLSM) is invariably followed by death.
Methods:
We performed a cohort study involving consecutive patients with WFNS grade 5 SAH to identify variables with >= 90% and >= 95% positive predictive value (PPV) for poor outcome (1-year modified Rankin Score >= 4), as well as findings predictive of WLSM.
Results:
Of 140 patients, 38 (27%) had favorable outcomes. Predictors with >= 95% PPV for poor outcome included unconfounded 72-hour Glasgow Coma Scale motor score <= 4, absence of >= 1 pupillary light reflex (PLR) at 24 hours, and intraventricular hemorrhage (IVH) score of >= 20 (volume >= 54.6 ml). Intracerebral hemorrhage (ICH) volume >= 53 ml had PPV of 92%. Variables associated with WLSM decisions included a poor motor score (p < 0.0001) and radiographic evidence of infarction (p = 0.02).
Conclusions:
We identified several early predictors with high PPV for poor outcome. Of these, lack of improvement in motor score during the initial 72 hours had the greatest potential for confounding from “self-fulfilling prophecy.” Absence of PLR at 24 hours, IVH score >= 20, and ICH volume >= 53 ml predicted poor outcome without a statistically significant effect on WLSM decisions. More research is needed to validate prognostic variables in grade 5 SAH, especially among patients who do not undergo WLSM.
Preterm birth (delivery <37 weeks of gestation) is associated with impaired glomerular capillary growth in neonates; if this persists, it may be a contributing factor in the increased risk of hypertension and chronic kidney disease in people born preterm. Therefore, in this study, we aimed to determine the long-term impact of preterm birth on renal morphology, in adult sheep. Singleton male sheep were delivered moderately preterm at 132 days (~0.9) of gestation (n = 6) or at term (147 days gestation; n = 6) and euthanised at 14.5 months of age (early adulthood). Stereological methods were used to determine mean renal corpuscle and glomerular volumes, and glomerular capillary length and surface area, in the outer, mid and inner regions of the renal cortex. Glomerulosclerosis and interstitial collagen levels were assessed histologically. By 14.5 months of age, there was no difference between the term and preterm sheep in body or kidney weight. Renal corpuscle volume was significantly larger in the preterm sheep than the term sheep, with the preterm sheep exhibiting enlarged Bowman’s spaces; however, there was no difference in glomerular volume between groups, with no impact of preterm birth on capillary length or surface area per glomerulus. There was also no difference in interstitial collagen levels or glomerulosclerosis index between groups. Findings suggest that moderate preterm birth does not adversely affect glomerular structure in early adulthood. The enlarged Bowman’s space in the renal corpuscles of the preterm sheep kidneys, however, is of concern and merits further research into its cause and functional consequences.
Laboratory experiments are conducted to examine the evolution of and sedimentation from a particle-bearing jet advancing along a horizontal or downward-sloping boundary underlying a uniform-density ambient fluid. The jet front advances along the bottom while exhibiting a self-similar profile. As the jet propagates downstream, particles settle out, resulting in a teardrop-shaped sediment bed whose geometric parameters are measured non-intrusively using a light attenuation technique. The bed shape is well represented by the theory that assumes a Gaussian radial profile of velocity within the jet and accounts for the bedload transport of particles after they settle. In particular, the bed length is given by $l_0 = (1.8 \pm 0.4) [M_0/(g^\prime d_p)]^{1/2}$, in which $M_0$ is the source momentum flux, $g^\prime$ is the reduced gravity of the particles and $d_p$ is the particle diameter. The corresponding scale for the sediment depth captures the anticipated order of magnitude for the maximum depth of deposit, but the measurements indicate additional dependence upon $M_0$, suggesting that the morphology of the bed non-negligibly influences particle settling.
Understanding the nucleosynthetic origin of nitrogen and the evolution of the N/O ratio in the interstellar medium is crucial for a comprehensive picture of galaxy chemical evolution at high-redshift because most observational metallicity (O/H) estimates are implicitly dependent on the N/O ratio. The observed N/O at high-redshift shows an overall constancy with O/H, albeit with a large scatter. We show that these heretofore unexplained features can be explained by the pre-supernova wind yields from rotating massive stars (M≳10M⊙,ν/νcrit≳0.4). Our models naturally produce the observed N/O plateau, as well as the scatter at low O/H. We find the scatter to arise from varying star formation efficiency. However, the models that have supernovae dominated yields produce a poor fit to the observed N/O at low O/H. This peculiar abundance pattern at low O/H suggests that dwarf galaxies are most likely to be devoid of SNe yields and are primarily enriched by pre-supernova wind abundances.
Necrotising otitis externa is a progressive infection of the external auditory canal which extends to affect the temporal bone and adjacent structures. Progression of the disease process can result in serious sequelae, including cranial nerve palsies and death. There is currently no formal published treatment guideline.
Objective
This study aimed to integrate current evidence and data from our own retrospective case series in order to develop a guideline to optimise necrotising otitis externa patient management.
Methods
A retrospective review of necrotising otitis externa cases within NHS Lothian, Scotland, between 2013 and 2018, was performed, along with a PubMed review.
Results
Prevalent presenting signs, symptoms and patient demographic data were established. Furthermore, features of cases associated with adverse outcomes were defined. A key feature of the guideline is defining at-risk patients with initial intensive treatment. Investigations and outcomes are assessed and treatment adjusted appropriately.
Conclusion
This multi-departmental approach has facilitated the development of a succinct, systematic guideline for the management of necrotising otitis externa. Initial patient outcomes appear promising.
A weakly nonlinear time-dependent theory for the evolution of superharmonics generated by the nonlinear self-interaction of a mode-1 internal tide in non-uniform stratification is developed and compared to numerical simulations. The forcing by the internal tide is found to excite near-pure mode-1 superharmonics whose natural frequency is moderately different from twice the internal tide frequency. Consequently, the superharmonics undergo a slow periodic growth and decay that is comparable to an acoustic ‘beat’. At low latitudes the beat frequency is smaller and the superharmonics can grow to larger amplitude, allowing for the possibility of a superharmonic cascade.
The logopenic variant of primary progressive aphasia (lvPPA) has disparate pathological and anatomical features when compared to the semantic (svPPA) and non-fluent (nfvPPA) variants of PPA. As such, there is increasing need for measures that improve diagnostic accuracy particularly when etiology-specific treatments become available. In the current study, we used meta-analytic methods to establish the neuropsychological profile of lvPPA and compare it to recent findings in svPPA and nfvPPA.
Methods:
We extracted neuropsychological data from 51 publications representing 663 lvPPA patients and 1379 controls. We calculated Hedges’ g effect sizes for nine domains of neuropsychological functioning in lvPPA and assessed the influence of demographic, disease, and task characteristics on effect size magnitude. Results obtained in lvPPA were compared to findings in svPPA and nfvPPA.
Results:
In lvPPA, the magnitude of deficits in attention, math, visuospatial memory, and executive functioning were as prominent as language deficits. Within the language domain, lvPPA patients demonstrated greater naming than repetition deficits. Compared to svPPA and nfvPPA, lvPPA patients demonstrated greater neuropsychological deficits overall and greater impairment on attention, math, and visual set-shifting tests.
Conclusions:
Tests of attention, delayed visuospatial memory, visual set-shifting, and math distinguish lvPPA from svPPA and nfvPPA likely reflecting the posterior temporoparietal atrophy observed early in the course of lvPPA. These findings support the inclusion of these measures in the clinical neuropsychological assessment of lvPPA and underscore the need for additional clinicopathological and longitudinal studies of arithmetic and visuospatial memory across the PPA variants.
We examine the flows induced by horizontally modulated, vertically confined (or guided), internal wavepackets in a stratified, Boussinesq fluid. The wavepacket induces both an Eulerian flow and a Stokes drift, which together determine the Lagrangian transport of passive tracers. We derive equations describing the wave-induced flows in arbitrary stable stratification and consider four special cases: a two-layer fluid, symmetric and asymmetric piecewise constant (‘top-hat’) stratification and, more representative of the ocean, exponential stratification. In a two-layer fluid, the Stokes drift is positive everywhere with the peak value at the interface, whereas the Eulerian flow is negative and uniform with depth for long groups. Combined, the net depth-integrated Lagrangian transport is zero. If one layer is shallower than the other, the wave-averaged interface displaces into that layer making the Eulerian flow in that layer more negative and the Eulerian flow in the opposite layer more positive so that the depth-integrated Eulerian transports are offset by the same amount in each layer. By contrast, in continuous stratification the depth-integrated transport due to the Stokes drift and Eulerian flow are each zero, but the Eulerian flow is singular if the horizontal phase speed of the induced flow equals the group velocity of the wavepacket, giving rise to a single resonance in uniform stratification (McIntyre, J. Fluid Mech., vol. 60, 1973, pp. 801–811). In top-hat stratification, this single resonance disappears, being replaced by multiple resonances occurring when the horizontal group velocity of the wavepacket matches the horizontal phase speed of higher-order modes. Furthermore, if the stratification is not vertically symmetric, then the Eulerian induced flow varies as the inverse squared horizontal wavenumber for shallow waves, the same as for the asymmetric two-layer case. This ‘infrared catastrophe’ also occurs in the case of exponential stratification suggesting significant backward near-surface transport by the Eulerian induced flow for modulated oceanic internal modes. Numerical simulations are performed confirming these theoretical predictions.
A sapphire, zircon and magnetite-bearing xenolith from Khao Wua, near Chanthaburi in Thailand, conclusively demonstrates a common origin for the sapphire, zircon and magnetite found in alluvial deposits in the Chanthaburi gem fields. The original aluminium- and titanium-rich octahedral magnetite crystal in the xenolith exsolved into hercynite, magnetite and hematite during cooling. It includes minor anhedral jarosite–alunite, possibly originating as an iron-sulphide-rich immiscible liquid. Uranium-lead isotope dating of zircon in the xenolith gives an age of 1–2 (± <1) million years (Ma). This falls within fission track ages for alluvial zircons (2.57 ± 0.20 Ma) from the Chanthaburi—Trat gem fields and within the potassium-argon ages of 0.44 to 3.0 Ma for the alkali basaltic volcanism in the Chanthaburi Province. These data suggest a common origin for sapphire, zircon and magnetite, and link them with the processes involved in alkali basaltic magma generation. The high iron and zirconium, low magnesium, and the inferred sulphides suggest pegmatite-like crystallization in an incompatible-element enriched, silica-poor magma (partial melt or fractionation product) in the deep crust or upper mantle. Etch features on exposed surfaces of the xenolith indicate that it was transported out of its equilibrium environment by the rise of later magma.
Uranium-lead isotope dating of two zircon inclusions in sapphires from the Central Province, NSW. gives ages of 35.9 ± 1.9 and 33.7 ± 2.1 million years (Ma). These ages fall within the range of basalt potassium-argon ages of 19 to 38Ma and zircon fission track ages of 2 to 49Ma for the timing of volcanism of the Central Province, NSW. These data, combined with the observation that corundum is found associated with many alkali basaltic provinces, indicate a genetic link between the growth of large corundum crystals and the processes involved in alkali basaltic magma generation. The reported failure of experimental attempts to grow corundum from a corundum-bearing basaltic composition, and more significantly, the abundance of incompatible elements such as U, Th, Zr, Nb and Ta in inclusion minerals indicate that the crystallization process is not simple. Corundum and the other minerals found as its inclusions (zircon, columbite, thorite, uranium pyrochlore, alkali feldspar etc.) could not have crystallized from most basaltic compositions. A more complex process must occur in which crystallization takes place when there are high proportions of incompatible elements and volatiles in the melt. These crystallization products are then carried to the surface by upward movement of later magmas. The extent of this process presumably determines whether a particular basaltic province carries sufficient corundum to be worked into economic concentrations of sapphire.
Alluvial rubies and sapphires are found in palaeodrainage deposits along the Cudgegong-Macquarie River system, central eastern New South Wales, Australia. A pink to red suite contains Cr (up to 0.6 wt.% Cr2O3) as the main chromophore, exceeding Fe (up to 0.5 wt.%Fe2O3). Corrosive etching suggests a prior xenocrystic Mesozoic-Cenozoic basaltic transport, while Cr2O3/Ga2O3 to Fe2O3/TiO2 ratios indicate an original metamorphic source. Syngenetic mineral inclusions include Al-rich diopside, meionite and anatase. The Al-rich diopside (‘fassaite’) contains extremely high Al2O3 (20–21 wt.%). A blue-green suite contains Fe (up to 0.8 wt.% Fe2O3) as a dominant chromophore, while a rare nepheline-anorthoclase composite inclusion supports a magmatic phonolitic origin. The Cudgegong- Macquarie ruby formation is compared with a garnet granulite origin proposed for Thailand rubies and a xenolith of corundum-bearing garnet granulite from Ruby Hill, Bingara, Australia. Clinopyroxenecorundum thermometry suggests the Cudgegong-Macquarie rubies formed at T >1000–1300ºC, a high equilibration T for proposed lithospheric granulites. These rubies form a distinctive suite compared to other rubies from Australian and SE Asian basalt fields, but have some similarities with eastern Thailand rubies.