This paper retrospectively analysed the prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) in some parts of China. Between January 2013 and December 2019, we collected 4,145 respiratory samples, including pharyngeal swabs and alveolar lavage fluid. The highest PCR-positive rate of M. pneumoniae was 74.5% in Beijing, the highest resistance rate was 100% in Shanghai, and Gansu was the lowest with 20%. The highest PCR-positive rate of M. pneumoniae was 74.5% in 2013, and the highest MRMP was 97.4% in 2019; the PCR-positive rate of M. pneumoniae for adults in Beijing was 17.9% and the MRMP was 10.48%. Among the children diagnosed with community-acquired pneumonia (CAP), the PCR-positive and macrolide-resistant rates of M. pneumoniae were both higher in the severe ones. A2063G in domain V of 23S rRNA was the major macrolide-resistant mutation, accounting for more than 90%. The MIC values of all MRMP to erythromycin and azithromycin were ≥ 64 μg/ml, and the MICs of tetracycline and levofloxacin were ≤ 0.5 μg/ml and ≤ 1 μg/ml, respectively. The macrolide resistance varied in different regions and years. Among inpatients, the macrolide-resistant rate was higher in severe pneumonia. A2063G was the common mutation, and we found no resistance to tetracycline and levofloxacin.

Findings from observational studies have suggested a possible association between dietary inflammatory index (DII) and risk of gestational diabetes mellitus (GDM) and preeclampsia (PE). However, the results of these studies were inconclusive. A systematic review and meta-analysis was carried out to illuminate this association. Systematic literature search was conducted in PubMed, Web of Science, Cochrane Library, EMBASE, Scopus and other databases from inception until January 2023. The qualities of included studies were assessed using the Newcastle–Ottawa scale. Nine studies (seven cohort, two case–control) were included in the meta-analysis, including 11 423 participants from five different countries. The meta-analysis indicated that a 1-unit increase in the DII score, representing pro-inflammatory diet, was associated with 13 % higher risk of GDM (OR = 1·13; 95 % CI 1·02, 1·25, I2 = 68·4 %, P = 0·004) and 24 % higher risk of PE (OR = 1·24; 95 % CI 1·14, 1·35, I2 = 52·0 %, P = 0·125). Subgroup analysis found that this association was evident among studies with Chinese populations (OR = 1·16; 95 % CI 1·06, 1·28) and studies with mid pregnancy (OR = 1·20; 95 % CI 1·07, 1·34). The findings indicate that pro-inflammatory diet can increase the risk of GDM and PE. Considering some limitations in this study, more studies are needed to verify this association.

Programmable active matter (PAM) combines information processing and energy transduction. The physical embodiment of information could be the direction of magnetic spins, a sequence of molecules, the concentrations of ions, or the shape of materials. Energy transduction involves the transformation of chemical, magnetic, or electrical energies into mechanical energy. A major class of PAM consists of material systems with many interacting units. These units could be molecules, colloids, microorganisms, droplets, or robots. Because the interaction among units determines the properties and functions of PAMs, the programmability of PAMs is largely due to the programmable interactions. Here, we review PAMs across scales, from supramolecular systems to macroscopic robotic swarms. We focus on the interactions at different scales and describe how these (often local) interactions give rise to global properties and functions. The research on PAMs will contribute to the pursuit of generalised crystallography and the study of complexity and emergence. Finally, we ponder on the opportunities and challenges in using PAM to build a soft-matter brain.

The oscillatory Kelvin–Helmholtz (K–H) instability of a planar liquid sheet was experimentally investigated in the presence of an axial oscillating gas flow. An experimental system was initiated to study the oscillatory K–H instability. The surface wave growth rates were measured and compared with theoretical results obtained using the authors’ early linear method. Furthermore, in a larger parameter range experimentally studied, it is interesting that there are four different unstable modes: first disordered mode (FDM), second disordered mode (SDM), K–H harmonic unstable mode (KHH) and K–H subharmonic unstable mode (KHS). These unstable modes are determined by the oscillating amplitude, oscillating frequency and liquid inertia force. The frequencies of KHH are equal to the oscillating frequency; the frequency of KHS equals half the oscillating frequency, while the frequencies of FDM and SDM are irregular. By considering the mechanism of instability, the instability regime maps on the relative Weber number versus liquid Weber number (Werel–Wel) and the Weber number ratio versus the oscillating frequency (Werel/Wel–$\varOmega$s2) were plotted. Among these four modes, KHS is the most unexpected: the frequency of this mode is not equal to the oscillating frequency, but the surface wave can also couple with the oscillating gas flow. Linear instability theory was applied to divide the parameter range between the different unstable modes. According to linear instability theory, K–H and parametric unstable regions both exist. However, note that all four modes (KHH, KHS, FDM and SDM) corresponded primarily to the K–H unstable region obtained from the theoretical analysis. Nevertheless, the parametric unstable mode was also observed when the oscillating frequency and amplitude were relatively low, and the liquid inertia force was relatively high. The surface wave amplitude was small but regular, and the evolution of this wave was similar to that of Faraday waves. The wave oscillating frequency was half that of the surface wave.

Due to the presence of geological fluid under actual geological conditions, water–rock interaction will occur between the fluid and reservoir. Thus, to analyse the influence of the water–rock interaction on storage space during the organic matter evolution stages, this study conducted a series of simulation experiments on shales by using a closed autoclave: four temperatures, 250°C, 300°C, 350°C, 400°C, and five fluid–rock ratios (FRRs), 0:20, 4:20, 10:20, 15:20, and 20:20. Low pressure N2 adsorption measurement was conducted on the solid residues. The experimental results show that the effect of temperature on the yield and pore structure of oil shale was the same as the result when the FRR was = 0:20, 4:20 and = 10:20, 15:20, 20:20, respectively. This result showed that temperature remained the main factor that affected the thermal evolution of hydrocarbon generation. Additionally, temperature was beneficial to the generation and storage of shale oil within a certain range, but only occupied the storage space of shale oils or connected a certain storage space beyond a certain range. The variation trend of shale oil yield with increasing FRR under the same simulated temperatures, 250°C and 400°C, was most affected by the FRR, but little change occurred at 300°C and 350°C. This further proved that the ratio of fluid to rock was an indirect acting factor, which affected the evolution of organic matters and then the development of pore structures. Before the oil window (350°C), the lower evolution degree, the higher water content and the more significant effect. In the higher evolution stage, the higher the water content, and the more complete the kerogen reaction, which was also more conducive to the development of pore structures. Therefore, this study promotes the establishment of linear equations on FRR to the gas adsorption capacity, which further provides a theoretical basis and guidance for the exploration and development of shale oil.

There have been calls for the expansion of protected areas (PAs) to tackle the ongoing biodiversity loss, yet it is unclear where future PAs might help to protect biodiversity in degraded landscapes under the conservation planning principles of complementarity, connectivity and cost-effectiveness. Our conservation goal is to increase the PA network coverage to up to 30% of the landscape of the Zhangjiang River Basin for target species in the karst area of southwest China, a global biodiversity hotspot. Zonation 4GUI was used to evaluate the adequacy of current PAs and to strategically expand PAs while maximizing the coverage of target species and considering ecological integrity and socioeconomic activities. The results show that significant habitat degradation has occurred across 77.9% of the basin. The current PAs cover 6.3% of the site and represent 8.7% of the total distribution of key species. With regards to the threshold of protection of 30% of the area, protecting an additional 27.2% of the site under an ecological integrity prioritization scenario and a scenario of the socioeconomic costs involved in iteration would cover 93.5% and 80.4% of the ranges of the key species, respectively. Our results can be used to inform the upcoming actions associated with karst area conservation-related policies.

To reveal the thermal shock resistance of double-layer thermal barrier coatings (TBCs), two types of TBCs were prepared via atmospheric plasma spraying, i.e., Gd2Zr2O7/yttria-stabilized zirconia (GZ/YSZ) TBCs and La2Zr2O7 (LZ)/YSZ TBCs, respectively. Subsequently, thermal cycling tests of the two TBCs were conducted at 1100 °C and their thermal shock resistance and failure mechanism were comparatively investigated through experiments and the finite element method. The results showed that the thermal shock failure of the two TBCs occurred inside the top ceramic coating. However, the GZ/YSZ TBCs had longer thermal cycling life. It was the mechanical properties of the top ceramic coating, and the thermal stresses arising from the thermal mismatch between the top ceramic coating and the substrate that determined the thermal cycling life of the two TBCs together. Compared with the LZ layer in the LZ/YSZ TBCs, the GZ layer in the GZ/YSZ TBCs had smaller elastic modulus, larger fracture toughness, and smaller thermal stresses, which led to the higher crack propagation resistance and less spallation tendency of the GZ/YSZ TBCs. Therefore, the GZ/YSZ TBCs exhibited superior thermal shock resistance to the LZ/YSZ TBCs.

Marine hydroids, the polyp stage of hydrozoans, are assumed to be carnivores and play an important role in benthic-pelagic coupling processes by regulating zooplankton populations and transferring energy. The known hydroid diets mainly consist of zooplankton as well as some benthic diatoms and metazoans, almost all of which have smaller dimensions than the polyp. In the present study, a large-scale breeding failure of the early juveniles of the ivory shell Babylonia areolata (Mollusca: Gastropoda: Babyloniidae) was found in a local aquaculture farm in Fujian, China in July 2018. About 640,000 out of 800,000 early juveniles (80%) died due to predation by a millimetre-sized colonial hydroid species that was initially overlooked. The hydrozoan species was identified as Eirene sp. (Cnidaria: Hydrozoa: Eirenidae) via the integration of morphological and molecular data. A laboratory feeding experiment showed that the hydroid predation led to an overall mortality of ivory shell juveniles of up to 92.6% after 48 h. The predation process was observed in the laboratory and a video showing the entire process was prepared. This is the first report of hydroids preying on gastropod juveniles, revealing a previously unknown threat to mollusc aquaculture including ivory shells. Several management practices are suggested to mitigate this newly recognized threat.

This report is on the synthesis by electrospinning of multiferroic core-shell nanofibers of strontium hexaferrite and lead zirconate titanate or barium titanate and studies on magneto-electric (ME) coupling. Fibers with well-defined core–shell structures showed the order parameters in agreement with values for nanostructures. The strength of ME coupling measured by the magnetic field-induced polarization showed the fractional change in the remnant polarization as high as 21%. The ME voltage coefficient in H-assembled films showed the strong ME response for the zero magnetic bias field. Follow-up studies and potential avenues for enhancing the strength of ME coupling in the core–shell nanofibers are discussed.

The COVID-19 outbreak is ongoing in China. Here, Boltzmann function-based analyses reveal the potential total numbers of COVID-19 deaths: 3,260 (95% confidence interval [CI], 3187–3394) in China; 110 (95% CI, 109–112) in Hubei Province; 3,174 (95% CI, 3095–3270) outside Hubei; 2,550 (95% CI, 2494–2621) in Wuhan City; and 617 (95% CI, 607–632) outside Wuhan.

The present paper deals with non-real eigenvalues of singular indefinite Sturm–Liouville problems with limit-circle type endpoints. A priori bounds and the existence of non-real eigenvalues of the problem associated with a special separated boundary condition are obtained.

Underground Nuclear Astrophysics in China (JUNA) will take the advantage of the ultra-low background in Jinping underground lab. High current accelerator with an ECR source and detectors were commissioned. JUNA plans to study directly a number of nuclear reactions important to hydrostatic stellar evolution at their relevant stellar energies. At the first period, JUNA aims at the direct measurements of 25Mg(p,γ)26 Al, 19F(p,α) 16 O, 13C(α, n) 16O and 12C(α,γ) 16O near the Gamow window. The current progress of JUNA will be given.

CrFeNiTix (x = 0.2, 0.3, 0.4, 0.5, and 0.6 molar ratio) compositionally complex alloys were fabricated by vacuum arc melting to investigate the microstructure, hardness, and compressive properties. The results revealed that CrFeNiTix alloys consisted of the principal face-centered cubic (FCC) phase and body-centered cubic (BCC) solid solution, with an amount of (Ni, Ti)-rich hexagonal close-packed phase. CrFeNiTix alloys exhibited the typical dendrite. Ti0.2 and Ti0.3 alloys were composed of FCC and BCC solid solutions in the dendrite, as well as ε (Ni3Ti) and R (Ni2.67Ti1.33) phases in the inter-dendrite, simultaneously. For Ti0.4, Ti0.5, and Ti0.6 alloys, (Fe, Cr)-rich solid solution separated out and ε phase transformed into R phase gradually. Meanwhile, TEM analysis indicated that Ti0.4 alloy matrix consisted of the principal FCC phase containing (Ni, Ti)-rich intragranular nanoprecipitates. The hardness values of CrFeNiTix alloys were increased with the addition of Ti content and the high compressive strength of CrFeNiTix alloys was maintained, which was attributed to the solid solution strengthening and precipitation hardening.

The influence of tilt on flow reversals in two-dimensional thermal convection in rectangular cells with two typical aspect ratios, $\unicode[STIX]{x1D6E4}=\text{width/height}=1$ and 2, are investigated by means of direct numerical simulations. For $\unicode[STIX]{x1D6E4}=1$, tilt tends to suppress flow reversals. However, it is found that flow reversals characterized by two main rolls are promoted by tilt for $\unicode[STIX]{x1D6E4}=2$, which are even observed for some cases of small Prandtl numbers ($Pr$) and large tilt angles ($\unicode[STIX]{x1D6FD}$). Different from level cases where the four corner rolls all have opportunities to grow and trigger a flow reversal, the reversals in an anticlockwise tilted cell with $\unicode[STIX]{x1D6E4}=2$ are always led by the growth of the bottom-right or the top-left corner roll. Tilt is favourable for the growth of the bottom-right or the top-left corner roll and thus for breaking the balance between the two main rolls and triggering a flow reversal. The mode decomposition analysis shows that the appearance of the intermediate single-roll mode is crucial for reversals, and flow reversals in a tilted cell with $\unicode[STIX]{x1D6E4}=2$ can be viewed as a mode competition process between single-roll mode and horizontally adjacent double-roll mode. They can only occur in a limited range of $\unicode[STIX]{x1D6FD}$ where the two modes have comparable strength. Furthermore, the Nusselt numbers at the hot plate $Nu_{h}$ and at the cold plate $Nu_{c}$ behave differently during a flow reversal for $\unicode[STIX]{x1D6E4}=2$ due to the preference of single corner roll growth.

Barium-rich silicates were recently found in the lower Cambrian black shale sequence of Anhui Province, South China. The Ba silicates can be divided into Ba-poor K-feldspar, Ba-rich K-feldspar and cymrite, on the basis of occurrence and composition. The Ba-poor K-feldspar have low BaO contents (<1.00 wt.%) and occur as sporadic grains in mudstone. In contrast, the Ba-rich K-feldspar have higher BaO contents (1.36–20.51 wt.%) and occur mainly as rims around grains of Ba-poor K-feldspar in mudstone, as void fillings in dolostone, and as grains dispersed in chert. The cymrite is observed only in chert and occurs as dispersed euhedral tabular crystals. Analyses of the Ba-poor K-feldspar and Ba-rich K-feldspar provide compositions that total <100 wt.% and show non-stoichiometry characterized by (Na + K + Ba + Ca)apfu less than 1.00 and (Al + Si)apfu slightly higher than 4.00. Raman and infrared (IR) spectroscopy has revealed the presence of ${\rm NH}_{\rm 4}^{\rm +} $ and H2O in the Ba-rich K-feldspar, which accounts for the unusual composition of these feldspars. We suggest that the formation processes of the Ba-poor K-feldspar, Ba-rich K-feldspar and cymrite were closely associated with multi-stage hydrothermal fluids enriched in Ba and NH4, consistent with an extensional tectonic setting during the early Cambrian. The Ba-poor K-feldspars might have formed through interactions between pre-existing K-feldspars and hydrothermal fluids. The Ba-rich K-feldspars in mudstone and dolostone formed mainly by precipitation from hydrothermal fluids that infiltrated the sediments, and we suggest the Ba-rich K-feldspars and cymrite in the chert are of exhalative hydrothermal origin.