The properties of the Local Bubble, Local Fluff complex of nearby interstellar clouds, and the heliosphere are mutually constrained by data and theory. Observations and models of the diffuse radiation field, interstellar ionization, pickup ion and anomalous cosmic-ray populations, and interstellar dust link the physics of these regions. The differences between the one-asymmetric-superbubble and twosuperbubble views of the Local Bubble are discussed.