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Nocturnal enuresis has been reported in patients taking clozapine, but
the incidence has not been accurately established. The incidence of
enuresis in patients taking risperidone, olanzapine or quetiapine is
To compare nocturnal enuresis in patients taking clozapine with that in
patients taking risperidone, olanzapine or quetiapine.
Observational cohort study using prescription event monitoring methods.
Patients prescribed atypical antipsychotic medicines were followed up by
questionnaires that were sent to their medical practitioner.
Practitioners were asked to directly ask their patients about
Nocturnal enuresis was reported by 17 of 82 (20.7%) patients taking
clozapine, 11 of 115 (9.6%) taking olanzapine, 7 of 105 (6.7%) taking
quetiapine and 12 of 195 (6.2%) taking risperidone. Compared with
clozapine, the risk of nocturnal enuresis was significantly lower in
patients taking olanzapine (odds ratio, OR = 0.43, 95% CI 0.19–0.96),
quetiapine (OR = 0.33, 95% CI 0.13–0.59) or risperidone (OR = 0.27,
0.12–0.59), with odds ratios adjusted for age, gender and duration of
Approximately one in five patients prescribed clozapine experienced
bed-wetting. This was significantly higher than the rate of nocturnal
enuresis in patients taking olanzapine, quetiapine or risperidone.
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