Bio-inspired design (BID) involves generating innovative ideas for engineering design by drawing inspiration from natural biological phenomena and systems, using a form of design-by-analogy. Despite its many successes, BID approaches encounter research challenges including unstructured data and existing models that hinder comprehension and processing, limited focus on finding biological knowledge compared to defined problems, and insufficient guidance of the ideation process with algorithms. This paper proposes a knowledge-based approach to address the challenges. The approach involves transforming unstructured data into structured knowledge, including information about natural sources, their benefits, and applications. The structured knowledge is then used to construct a semantic network, enabling designers to retrieve information for BID in two ways. Furthermore, a three-step ideation method is developed to encourage divergent thinking and explore additional potential solutions by drawing inspiration and utilizing knowledge. The knowledge-based BID approach is implemented as a tool and design cases are conducted to illustrate the process of applying this tool for BID.

In the field of content generation by machine, the state-of-the-art text-to-image model, DALL⋅E, has advanced and diverse capacities for the combinational image generation with specific textual prompts. The images generated by DALL⋅E seem to exhibit an appreciable level of combinational creativity close to that of humans in terms of visualizing a combinational idea. Although there are several common metrics which can be applied to assess the quality of the images generated by generative models, such as IS, FID, GIQA, and CLIP, it is unclear whether these metrics are equally applicable to assessing images containing combinational creativity. In this study, we collected the generated image data from machine (DALL⋅E) and human designers, respectively. The results of group ranking in the Consensual Assessment Technique (CAT) and the Turing Test (TT) were used as the benchmarks to assess the combinational creativity. Considering the metrics’ mathematical principles and different starting points in evaluating image quality, we introduced coincident rate (CR) and average rank variation (ARV) which are two comparable spaces. An experiment to calculate the consistency of group ranking of each metric by comparing the benchmarks then was conducted. By comparing the consistency results of CR and ARV on group ranking, we summarized the applicability of the existing evaluation metrics in assessing generative images containing combinational creativity. In the four metrics, GIQA performed the closest consistency to the CAT and TT. It shows the potential as an automated assessment for images containing combinational creativity, which can be used to evaluate the images containing combinational creativity in the relevant task of design and engineering such as conceptual sketch, digital design image, and prototyping image.

Negative symptoms of schizophrenia manifest as reduced motivation and pleasure (MAP) and impaired emotional expressivity (EXP). These can occur as primary phenomena, but have also been suggested to occur secondary to other clinical factors, including antipsychotic-induced sedation. However, this relationship has not been established formally. Here, we examined the effect of antipsychotic-induced sedation (assessed via the proxy of total daily sleep duration) on MAP and EXP in a cohort of 187 clozapine-treated patients with schizophrenia followed for over 2 years on average, using multilevel regression and mediation models. MAP, but not EXP, was adversely influenced by sedation, independently of the severity of psychosis or depression. Moreover, clozapine impaired MAP indirectly by worsening sedation, but after accounting for clozapine-induced sedation, clozapine improved MAP. Our results highlight the importance of addressing sedative side-effects of antipsychotics to improve clinical outcomes.

This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the disability-adjusted life years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3053 studies of which 2948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results.

Gradual typing allows programs to enjoy the benefits of both static typing and dynamic typing. While it is often desirable to migrate a program from more dynamically typed to more statically typed or vice versa, gradual typing itself does not provide a way to facilitate this migration. This places the burden on programmers who have to manually add or remove type annotations. Besides the general challenge of adding type annotations to dynamically typed code, there are subtle interactions between these annotations in gradually typed code that exacerbate the situation. For example, to migrate a program to be as static as possible, in general, all possible combinations of adding or removing type annotations from parameters must be tried out and compared. In this paper, we address this problem by developing migrational typing, which efficiently types all possible ways of replacing dynamic types with fully static types for a gradually typed program. The typing result supports automatically migrating a program to be as static as possible or introducing the least number of dynamic types necessary to remove a type error. The approach can be extended to support user-defined criteria about which annotations to modify. We have implemented migrational typing and evaluated it on large programs. The results show that migrational typing scales linearly with the size of the program and takes only 2–4 times longer than plain gradual typing.

The concept of socioemotional wealth (SEW) has become a dominant perspective in family business studies. In this article, we review the SEW literature, the explanatory power of SEW in family firm behavior, and the heterogeneity of family firms. Although we find that SEW distinguishes the behavior of family firms from that of nonfamily firms, the concept has been used and operationalized differently across studies. The few studies that measure SEW directly do not find clear and consistent explanatory power of the construct. Moreover, not many studies are conducted in Asian countries such as Japan, Korea, and China, raising the question as to whether the concept applies equally across institutional and cultural contexts. This article takes a pragmatic perspective on SEW by discussing and distinguishing between key dimensions of social wealth and emotional wealth, which we believe can enhance understanding of the behavior and heterogeneity of family businesses. Based on our deconstruction of the SEW concept, we propose various directions of future research.

Prolonged parturition duration has been widely demonstrated to be a risk factor for incidence of stillbirth. This study evaluated the supply of dietary fibre on the parturition duration, gut microbiota and metabolome using sows as a model. A total of 40 Yorkshire sows were randomly given diet containing normal level of dietary fibre (NDF, 17·5 % dietary fibre) or high level of dietary fibre (HDF, 33·5 % dietary fibre). Faecal microbiota profiled with 16S rRNA amplicon sequencing, SCFA and metabolome in the faeces and plasma around parturition were compared between the dietary groups. Correlation analysis was conducted to further explore the potential associations between specific bacterial taxa and metabolites. Results showed that HDF diet significantly improved the parturition process as presented by the shorter parturition duration. HDF diet increased the abundance of the phyla Bacteroidetes and Synergistetes and multiple genera. Except for butyrate, SCFA levels in the faeces and plasma of sows at parturition were elevated in HDF group. The abundances of fifteen and twelve metabolites in the faeces and plasma, respectively, markedly differ between HDF and NDF sows. These metabolites are involved in energy metabolism and bacterial metabolism. Correlation analysis also showed associations between specific bacteria taxa and metabolites. Collectively, our study indicates that the improvement of parturition duration by high fibre intake in late gestation is associated with gut microbiota, production of SCFA and other metabolites, potentially serving for energy metabolism.

Persisting symptoms and dysfunction after SARS-CoV-2 infection have frequently been observed. However, information on the aftermath of COVID-19 is inadequate. We followed up people with severe mental illness (SMI) infected with SARS-CoV-2, and evaluated their longer-term mortality, using data from Cambridgeshire and Peterborough NHS Foundation Trust, UK. We examined the time course and duration of mortality risk from the point of diagnosis. After SARS-CoV-2 infection, people with SMI had a substantially higher risk of death (hazard ratio (HR) = 5.16, 95% confidence interval (CI) 1.56–17.03; P = 0.007) during the first 28 days and during the following 28–60 days (HR = 2.96, 95% CI 1.21–7.26; P = 0.018) than those without infection, but after 60 days the additional risk of death was no longer significant (HR = 2.33, 95% CI 0.83–6.53; P = 0.107).