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3 results

  • Chapter 6 - Genes Are Not the Whole Story: Retrotransposons as New Determinants of Male Fertility

  • Edited by Stéphane Viville, Laboratoire de Génétique Médicale de Strasbourg and Laboratoire de diagnostic génétique, Strasbourg, Karen D. Sermon, Reproduction and Genetics Research Group, Vrije Universiteit Brussel
  • Book: Textbook of Human Reproductive Genetics
  • Published online: 15 December 2022
  • Print publication: 05 January 2023, pp 83-98

  • Summary

    The release of the human genome sequence has revealed that our genes represent only a minor fraction, with exons making up less than 2% of our DNA. In contrast, transposable elements represent some 45% of the genomic mass. Contrary to other species such as Drosophila or plants, these elements are not clustered in specific chromosomal regions in mammals, but are rather scattered throughout the genome, residing between but also inside genes. The transposon landscape of our genome reflects an evolutionary tug-of-war between integration and propagation events orchestrated by these elements, and counteracting defense mechanisms exerted by the host.