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1 results

  • Chapter 5 - Immune Complex Mediated Glomerular Diseases

  • from Section 2 - Glomerular Diseases
  • Edited by Helen Liapis, Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
  • Book:
    Pediatric Nephropathology & Childhood Kidney Tumors
    Published online:
    10 August 2023
    Print publication:
    09 March 2023, pp 87-120

  • Summary

    In many diseases, etiopathogenesis relies on dysregulation of the immune system – either secondary to a recognized underlying condition or primary due to an unknown cause ؘ– that will lead to a wide spectrum of glomerular disorders and a broad range of clinical symptoms from nephritic to nephrotic syndrome. This chapter outlines the most important clinicopathological entities related to immune-complex formation. Recent advances in our understanding of the role of complement in the pathogenesis of many immune-complex mediated diseases have led to the description of new diseases and novel classifications based more on the etiopathogenesis than on pure morphological findings. We briefly discuss the pathogenesis of immune-complex mediated diseases, now expanding to include genetics and/or genetic susceptibility, which are influencing patient management.