In 2008 European Commission launches the open access infrastructure for research in Europe project (OpenAIRE), supporting open access (OA) in scientific information and research output. In this paper, we assess the economic sustainability of the OpenAIRE project. The empirical strategy is developed through a Cost–Benefit Analysis framework to evaluate and compare the costs and benefits of OpenAIRE services to provide recommendations on the project’s economic efficiency and sustainability, a non-market valuation method based on the results of a “Choice Experiment” to calculate the Total Economic Value generated by OpenAIRE and a full preference ranking approach. Findings indicate that stakeholders prefer interoperability between research platforms and output, better access to scientific results and compliance to OA mandates. Furthermore, net social benefits for the basic services for 15 years are at least five times higher than costs’ present value while the potential R&D effect from research suggests even larger benefits in the long run. Subscriptions based on the estimated willingness to pay and cost, institutional subsidies and public awareness are the main recommendations for the sustainable operation of OpenAIRE. This study contributes to the literature on monetary valuation of the benefits and costs of OA to scientific knowledge.