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Kaiser's measure of sampling adequacy is applied to a special Spearman matrix and a special q-cluster generalization. The result supports the contention that the measure should be no less than .5 for data to be appropriate for factor analysis.
Adsorption isotherms of HCN by Cu- and Ca-montmorillonites show that water present in the interlayer space decreases HCN adsorption.
For Ca-montmorillonite, i.r. spectra permit distinguishing between HCN interacting with the cations and molecules filling the interlayer space. Both types are removed upon outgassing. The residual water is not displaced by HCN.
On Cu-montmorillonite, species (presumably CN− ions) strongly held by the cations are observed in addition to adsorbed HCN molecules. The residual hydroxyls retained in the interlayer space are removed by the adsorption of HCN. These hydroxyls, either OH− or H2O, are characterized by two well defined stretching bands.
Infra-red spectra of samples heated below 200°C show that adsorbed HCN is involved in chemical reactions. For both clays, bands appear in the region characteristic of carbonyl and carboxyl groups; the production of ammonium is detected for Cu-montmorillonite. The reactions and the observed spectral features could be accounted for by the formation of formamide.
To assess cost-effectiveness of late time-window endovascular treatment (EVT) in a clinical trial setting and a “real-world” setting.
Methods:
Data are from the randomized ESCAPE trial and a prospective cohort study (ESCAPE-LATE). Anterior circulation large vessel occlusion patients presenting > 6 hours from last-known-well were included, whereby collateral status was an inclusion criterion for ESCAPE but not ESCAPE-LATE. A Markov state transition model was built to estimate lifetime costs and quality-adjusted life-years (QALYs) for EVT in addition to best medical care vs. best medical care only in a clinical trial setting (comparing ESCAPE-EVT to ESCAPE control arm patients) and a “real-world” setting (comparing ESCAPE-LATE to ESCAPE control arm patients). We performed an unadjusted analysis, using 90-day modified Rankin Scale(mRS) scores as model input and analysis adjusted for baseline factors. Acceptability of EVT was calculated using upper/lower willingness-to-pay thresholds of 100,000 USD/50,000 USD/QALY.
Results:
Two-hundred and forty-nine patients were included (ESCAPE-LATE:n = 200, ESCAPE EVT-arm:n = 29, ESCAPE control-arm:n = 20). Late EVT in addition to best medical care was cost effective in the unadjusted analysis both in the clinical trial and real-world setting, with acceptability 96.6%–99.0%. After adjusting for differences in baseline variables between the groups, late EVT was marginally cost effective in the clinical trial setting (acceptability:49.9%–61.6%), but not the “real-world” setting (acceptability:32.9%–42.6%).
Conclusion:
EVT for LVO-patients presenting beyond 6 hours was cost effective in the clinical trial setting and “real-world” setting, although this was largely related to baseline patient differences favoring the “real-world” EVT group. After adjusting for these, EVT benefit was reduced in the trial setting, and absent in the real-world setting.
Rotation plays an important role in the structure and evolution of massive stars. It leads to deviation from spherical symmetry for very fast rotating stars, mixing in otherwise unmixed radiative regions and generally increased mass loss. In addition, magnetic fields interact with rotation and lead to significant transport of angular momentum. In this article, we review the various rotational and magnetic instabilities present in massive stars and their implementation in one-dimensional stellar evolution codes. We then focus on their impact on the evolution of single rotating stars. Finally, we compare rotating models to observations and discuss ways to disentangle between various uncertainties.
SwissFEL is a compact, high-brilliance, soft and hard X-ray free electron laser (FEL) facility that started user operation in 2019. The facility is composed of two parallel beam lines seeded by a common linear accelerator (LINAC), and a two-bunch photo-injector. For the injector, an innovative dual-photocathode laser scheme has been developed based on state-of-the-art ytterbium femtosecond laser systems. In this paper, we describe the performance of the SwissFEL photocathode drive lasers (PCDLs), the pulse-shaping capabilities as well as the versatility of the systems, which allow many different modes of operation of SwissFEL. The full control over the SwissFEL electron bunch properties via the unique architecture of the PCDLs will enable in the future the advent of more-advanced FEL modes; these modes include, but are not restricted to, the generation of single or trains of sub-femtosecond FEL pulses, multi-color FEL and finally, the generation of fully coherent X-ray pulses via laser-based seeding.
Negative symptoms of schizophrenia remain a major therapeutic challenge. The progress in the conceptualization and assessment is not yet fully reflected by treatment research. Nevertheless, there is a growing evidence base regarding the effects of biological and psychosocial interventions on negative symptoms. The importance of the distinction between primary and secondary negative symptoms for treatment selection might seem evident, but the currently available evidence remains limited. Good clinical practice is recommended for the treatment of secondary negative symptoms. Antipsychotic treatment should be optimized to avoid secondary negative symptoms due to side effects and due to positive symptoms. For most available interventions, further evidence is needed to formulate sound recommendations for primary, persistent, or predominant negative symptoms.
However, based on currently available evidence recommendations for the treatment of undifferentiated negative symptoms (including both primary and secondary negative symptoms) are provided. Although it has proven difficult to formulate an evidence-based recommendation for the choice of an antipsychotic, a switch to a second-generation antipsychotic should be considered for patients who are treated with a first-generation antipsychotic. Antidepressant add-on to antipsychotic treatment is an option. Social skills training is recommended as well as cognitive remediation for patients who also show cognitive impairment. Exercise interventions also have shown promise. Finally, access to treatment and to psychosocial rehabilitation should be ensured for patients with negative symptoms. Overall, there is definitive progress in the field, but further research is clearly needed to develop specific treatments for negative symptoms.
During the last decades, a renewed interest for negative symptoms (NS) was brought about by the increased awareness that they interfere severely with real-life functioning, particularly when they are primary and persistent.
Methods
In this guidance paper, we provide a systematic review of the evidence and elaborate several recommendations for the conceptualization and assessment of NS in clinical trials and practice.
Results
Expert consensus and systematic reviews have provided guidance for the optimal assessment of primary and persistent negative symptoms; second-generation rating scales, which provide a better assessment of the experiential domains, are available; however, NS are still poorly assessed both in research and clinical settings.
This European Psychiatric Association (EPA) guidance recommends the use of persistent negative symptoms (PNS) construct in the context of clinical trials and highlights the need for further efforts to make the definition of PNS consistent across studies in order to exclude as much as possible secondary negative symptoms. We also encourage clinicians to use second-generation scales, at least to complement first-generation ones.
The EPA guidance further recommends the evidence-based exclusion of several items included in first-generation scales from any NS summary or factor score to improve NS measurement in research and clinical settings. Self-rated instruments are suggested to further complement observer-rated scales in NS assessment.
Several recommendations are provided for the identification of secondary negative symptoms in clinical settings.
Conclusions
The dissemination of this guidance paper may promote the development of national guidelines on negative symptom assessment and ultimately improve the care of people with schizophrenia.
The Continuous Performance Test (CPT) has become an essential constituent of the neuropsychological investigation of schizophrenia. Also, a vast number of brain imaging studies, mostly PET investigations, have employed the CPT as a cognitive challenge and established a relative hypofrontality in schizophrenics compared to controls. The aim of the present investigation was to clarify whether this predescribed hypofrontality could also be verified using functional magnetic resonance imaging (fMRI). 20 healthy volunteers and 14 schizophrenics on stable neuroleptic medication were included. Imaging was performed using the CPT-double-T-version and a clinical 1.5 T MRI-scanner with a single slice technique and a T2*-weighted gradient-echo-sequence. The schizophrenics exhibited a decreased activation in the right mesial prefrontal cortex, the right cingulate and the left thalamus compared to controls. These results obtained by fMRI are discussed in relation to published findings using PET.
Silico-ferric coprecipitates, with chemical formula , were aged in suspension at 75°, 100° and 150°C and the structural evolution of solids with time studied by XRD, TEM, and IR, Mössbauer and EXAFS spectroscopy. The initial Si-Fe coprecipitate was found to be amorphous but showed local order similar to that of a smectite layer. At 75°C only a weak structural evolution of the silico-ferric product towards a smectite-like structure was observed. Experiments performed at 100° and 150°C led to synthesis of a ferric smectite with structural formula . During syntheses a highly soluble silico-ferric complex appeared; the Si/Fe atomic ratio of this complex was 3, and the apparent concentration of Fe3+ in solution reached 27 mm/l. These syntheses prove that the crystallization of a dioctahedral smectite, containing only Fe3+ atoms in the octahedral sheet, is possible under strictly oxidizing conditions. However, crystal growth of a ferric smectite under these conditions is slow and only syntheses carried out at sufficiently high temperatures give convincing results.
Exposure to threat-related early life stress (ELS) has been related to vulnerability for stress-related disorders in adulthood, putatively via disrupted corticolimbic circuits involved in stress response and regulation. However, previous research on ELS has not examined both the intrinsic strength and flexibility of corticolimbic circuits, which may be particularly important for adaptive stress responding, or associations between these dimensions of corticolimbic dysfunction and acute stress response in adulthood.
Methods
Seventy unmedicated women varying in history of threat-related ELS completed a functional magnetic resonance imaging scan to evaluate voxelwise static (overall) and dynamic (variability over a series of sliding windows) resting-state functional connectivity (RSFC) of bilateral amygdala. In a separate session and subset of participants (n = 42), measures of salivary cortisol and affect were collected during a social-evaluative stress challenge.
Results
Higher severity of threat-related ELS was related to more strongly negative static RSFC between amygdala and left dorsolateral prefrontal cortex (DLPFC), and elevated dynamic RSFC between amygdala and rostral anterior cingulate cortex (rACC). Static amygdala-DLPFC antagonism mediated the relationship between higher severity of threat-related ELS and blunted cortisol response to stress, but increased dynamic amygdala-rACC connectivity weakened this mediated effect and was related to more positive post-stress mood.
Conclusions
Threat-related ELS was associated with RSFC within lateral corticolimbic circuits, which in turn was related to blunted physiological response to acute stress. Notably, increased flexibility between the amygdala and rACC compensated for this static disruption, suggesting that more dynamic medial corticolimbic circuits might be key to restoring healthy stress response.
The effect of capital structure and seasonality of fresh market vegetables was examined via the Target MOTAD model. The level of capital indebtedness and the selection of either a fall or spring season resulted in significantly different levels of enterprise mixes, expected returns, risk magnitudes, rates of change of risk magnitudes, and operating capital requirements. The fall season demonstrated larger initial levels of risk and larger increases in the level of risk due to increases in indebtedness. The spring season showed larger increases in risk between the minimum risk point and the maximum expected return point (linear programming solution) on the risk-efficient frontier. Operating capital requirements were substantially higher for the fall season than for the spring season. The operating capital requirements of the spring season were significantly affected by the level of indebtedness and the magnitude of risk selected by the grower, while the larger operating capital requirements of the fall season were only marginally affected.
A new site with Lateglacial palaeosols covered by 0.8 - 2.4 m thick aeolian sands is presented. The buried soils were subjected to multidisciplinary analyses (pedology, micromorphology, geochronology, dendrology, palynology, macrofossils). The buried soil cover comprises a catena from relatively dry (’Nano’-Podzol, Arenosol) via moist (Histic Gleysol, Gleysol) to wet conditions (Histosol). Dry soils are similar to the so-called Usselo soil, as described from sites in NW Europe and central Poland. The buried soil surface covers ca. 3.4 km2. Pollen analyses date this surface into the late Allerød. Due to a possible contamination by younger carbon, radiocarbon dates are too young. OSL dates indicate that the covering by aeolian sands most probably occurred during the Younger Dryas. Botanical analyses enables the reconstruction of a vegetation pattern typical for the late Allerød. Large wooden remains of pine and birch were recorded.
High-redshift quasars are unique probes of the evolution of supermassive black holes and the intergalactic medium at the end of the epoch of reionization. We present the optical spectra of eight new z ~ 6 quasars selected from the Panoramic Survey Telescope & Rapid Response System 1 (Pan-STARRS1). Details of the selection strategy can be found in Bañados et al. (2014). With this work we increase the number of known quasars at z < 5.7 by more than 10%. The quasars discovered here span a large range of luminosities (19.6 ≤ zP1 ≤ 21.2) and are remarkably heterogeneous in their spectral features: half of them show bright emission lines whereas the other half show weak or no Lyα emission line. We find a larger fraction of weak–line emission quasars than in lower redshift studies, although still based on low number statistics, this may imply that the quasar population could be more diverse than previously thought.
Village chickens have been kept for millennia under patronage of smallholder farmers. Our study was intended at dissecting the signature of artificial selection and ecological variation on morphological structures of Ethiopian village chickens. This report was based on visual traits of 798 chickens and a concise one-to-one interview of 399 farmers for their preferences on chicken morphology. Significant population-specific differences in morphological counts were commonly found for rare morphological variants. Most of them were frequently seen in Jarso chickens, while some of them unique to Jarso chickens. This might be explained by the effect of location-specific evolutionary forces and differences in their breeding histories. The high within population variation in the frequency of morphological counts was observed among these panmictic chicken populations largely evolved under uncontrolled mating. Single comb was not (less) preferred by majority of the farmers (93.8 percent); it was thus present at a low frequency (26.7 percent). Farmers have shown high preference for yellow shank (42.3 percent), which was then frequently observed (61.1 percent). The reported reasons for morphological likeness were visual appeal, market demand and cultural and religious values. The absence of significant variation in preferences for chicken morphology among communities between the two study sites was attributed to their multifunctional needs.
The IntCal09 and Marine09 radiocarbon calibration curves have been revised utilizing newly available and updated data sets from 14C measurements on tree rings, plant macrofossils, speleothems, corals, and foraminifera. The calibration curves were derived from the data using the random walk model (RWM) used to generate IntCal09 and Marine09, which has been revised to account for additional uncertainties and error structures. The new curves were ratified at the 21st International Radiocarbon conference in July 2012 and are available as Supplemental Material at www.radiocarbon.org. The database can be accessed at http://intcal.qub.ac.uk/intcal13/.