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The HCV has been associated with significant impairment of quality of life, irrespective of the degree of liver injury. The association of this disease with psychiatric comorbidities, especially depression, has been well described in the scientific literature. However, despite also significantly affect the quality of life of individuals, the Posttraumatic Stress Disorder (PTSD) has not been well studied in this population.
Evaluate whether individuals perceive the liver disease as a potentially traumatic experience and investigate the impact of PTSD diagnosis on health-related quality of life in hepatitis C virus-infected subjects.
We conducted a cross-sectional survey of 127 consecutive hepatitis C-infected outpatients. We investigated Traumatic Experiences and the subject's perception about the disease using the Trauma History Questionnaire. PTSD and others psychiatry diagnoses were assessed trough M.I.N.I. PLUS. Quality of life was assessed by the Short-Form 36.
Approximately 38.6% of the patients perceived the hepatitis C as a traumatic experience, 60.7% had PTSD diagnosis. It were no associate with the disease severity (been eligible for transplant), however there was a significant association with diagnosis of PTSD (p = 0.003). Roughly 22% of the sample showed PTSD diagnosis. PTSD imposed a significant impairment in quality of life of individuals in seven of the eight domains in the bivariate and multivariate analysis. This difference remained significant after adjustment for covariates such as major depressive disorder comorbidity.
The results suggest high prevalence of PTSD diagnosis in VHC infected patients and it impose impairment in their quality of life.
To review the historical evolution of the Fatigue Impact Scale (FIS), presenting its main features and modified versions.
Two independent reviewers performed a search in PubMed for articles, available since the development of the scale until June 2012, looking for those studies that used the FIS or any of its modified versions as an instrument for data collection. The terms used for the search were “Fatigue Impact Scale.” After individual analysis and consensus procedure, 201 articles were selected for the data basis of this study. Data were extracted using standardized forms with the following information: version of the scale, year and country where the study was conducted, the methodological study's design, language in which the scale was applied, and how many patients responded to any one of the versions.
This review found 4 validated modified versions of FIS and 2 reduced forms, in 27 different countries. The largest concentration was in United States, followed by other English-speaking countries. The FIS was the version most commonly used, followed by the Modified Fatigue Impact Scale (MFIS). Approximately 46,483 individuals have been evaluated with one of the versions of FIS in 29 different pathologies. Most of these studies used a cross-sectional design.
The number of studies using the FIS and its modifications has grown substantially. However, this study evaluates methodological limitations which still hinder the synthesis of the scale's performance through meta-analysis. Still, the FIS has been used in relevant studies that contribute to understand fatigue broadly.
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