We report results and modelling of an experiment performed at the Target Area West Vulcan laser facility, aimed at investigating laser–plasma interaction in conditions that are of interest for the shock ignition scheme in inertial confinement fusion (ICF), that is, laser intensity higher than ${10}^{16}$ $\mathrm{W}/{\mathrm{cm}}^2$ impinging on a hot ($T>1$ keV), inhomogeneous and long scalelength pre-formed plasma. Measurements show a significant stimulated Raman scattering (SRS) backscattering ($\sim 4\%{-}20\%$ of laser energy) driven at low plasma densities and no signatures of two-plasmon decay (TPD)/SRS driven at the quarter critical density region. Results are satisfactorily reproduced by an analytical model accounting for the convective SRS growth in independent laser speckles, in conditions where the reflectivity is dominated by the contribution from the most intense speckles, where SRS becomes saturated. Analytical and kinetic simulations well reproduce the onset of SRS at low plasma densities in a regime strongly affected by non-linear Landau damping and by filamentation of the most intense laser speckles. The absence of TPD/SRS at higher densities is explained by pump depletion and plasma smoothing driven by filamentation. The prevalence of laser coupling in the low-density profile justifies the low temperature measured for hot electrons ($7\!{-}\!12$ keV), which is well reproduced by numerical simulations.

The design and the early commissioning of the ELI-Beamlines laser facility’s 30 J, 30 fs, 10 Hz HAPLS (High-repetition-rate Advanced Petawatt Laser System) beam transport (BT) system to the P3 target chamber are described in detail. It is the world’s first and with 54 m length, the longest distance high average power petawatt (PW) BT system ever built. It connects the HAPLS pulse compressor via the injector periscope with the 4.5 m diameter P3 target chamber of the plasma physics group in hall E3. It is the largest target chamber of the facility and was connected first to the BT system. The major engineering challenges are the required high vibration stability mirror support structures, the high pointing stability optomechanics as well as the required levels for chemical and particle cleanliness of the vacuum vessels to preserve the high laser damage threshold of the dielectrically coated high-power mirrors. A first commissioning experiment at low pulse energy shows the full functionality of the BT system to P3 and the novel experimental infrastructure.

Laser–plasma interaction (LPI) at intensities $10^{15}{-}10^{16}~\text{W}\cdot \text{cm}^{-2}$ is dominated by parametric instabilities which can be responsible for a significant amount of non-collisional absorption and generate large fluxes of high-energy nonthermal electrons. Such a regime is of paramount importance for inertial confinement fusion (ICF) and in particular for the shock ignition scheme. In this paper we report on an experiment carried out at the Prague Asterix Laser System (PALS) facility to investigate the extent and time history of stimulated Raman scattering (SRS) and two-plasmon decay (TPD) instabilities, driven by the interaction of an infrared laser pulse at an intensity ${\sim}1.2\times 10^{16}~\text{W}\cdot \text{cm}^{-2}$ with a ${\sim}100~\unicode[STIX]{x03BC}\text{m}$ scalelength plasma produced from irradiation of a flat plastic target. The laser pulse duration (300 ps) and the high value of plasma temperature (${\sim}4~\text{keV}$) expected from hydrodynamic simulations make these results interesting for a deeper understanding of LPI in shock ignition conditions. Experimental results show that absolute TPD/SRS, driven at a quarter of the critical density, and convective SRS, driven at lower plasma densities, are well separated in time, with absolute instabilities driven at early times of interaction and convective backward SRS emerging at the laser peak and persisting all over the tail of the pulse. Side-scattering SRS, driven at low plasma densities, is also clearly observed. Experimental results are compared to fully kinetic large-scale, two-dimensional simulations. Particle-in-cell results, beyond reproducing the framework delineated by the experimental measurements, reveal the importance of filamentation instability in ruling the onset of SRS and stimulated Brillouin scattering instabilities and confirm the crucial role of collisionless absorption in the LPI energy balance.

This paper provides a summary of recent research connected with the shock ignition (SI) concept of the inertial confinement fusion which was carried out at PALS. In the experiments, Cu planar targets coated with a thin CH layer were used. Two-beam irradiation experiment was applied to investigate the effect of preliminary produced plasma to shock-wave generation. The 1ω or 3ω main beam with a high intensity >1015 W/cm2 generates shock wave, while the other 1ω beam with the intensity below 1014 W/cm2 creates CH pre-plasma simulating the pre-compressed plasma related to SI. Influence of laser wavelength on absorbed energy transfer to shock wave was studied by means of femtosecond interferometry and measuring the crater volume. To characterize the hot electron and ion emission, two-dimensional (2D) Kα-imaging of Cu plasma and grid collector measurements were used. In single 1ω beam experiments energy transport by fast electrons produced by resonant absorption made a significant contribution to shock-wave pressure. However, two-beam experiments with 1ω main beam show that the pre-plasma is strongly degrading the scalelength which leads to decreasing the fast electron energy contribution to shock pressure. In both the single 3ω beam experiments and the two-beam experiments with the 3ω main beam, do not show any clear influence of fast electron transport on shock-wave pressure. The non-monotonic behavior of the scalelength at changing the laser beam focal radius in both presence and absence of pre-plasma reflects the competition of plasma motion and electron heat conduction under the conditions of one-dimensional and 2D plasma expansion at large and small focal radii, respectively.

The paper is a continuation of research carried out at Prague Asterix Laser System (PALS) related to the shock ignition (SI) approach in inertial fusion, which was carried out with use of 1ω main laser beam as the main beam generating a shock wave. Two-layer targets were used, consisting of Cu massive planar target coated with a thin polyethylene layer, which, in the case of two-beam irradiation geometry, simulate conditions related to the SI scenario. The investigations presented in this paper are related to the use of 3ω to create ablation pressure for high-power shock wave generation. The interferometric studies of the ablative plasma expansion, complemented by measurements of crater volumes and Kα emission, clearly demonstrate the effect of changing the incident laser intensity due to changing the focal radius on efficiency of laser energy transfer to a shock wave and fast electron emission. The efficiency of the energy transfer increases with the radius of the focused laser beam. The pre-plasma does not significantly change the character of this effect. However, it unambiguously results in the increasing temperature of fast electrons, the total energy of which remains very small (<0.1% of the laser energy). This study shows that the optimal radius from the point of view of 3ω radiation energy transfer to the shock wave is the maximal one used in these experiments and equal to 200 µm that corresponds to the minimal effect of two-dimensional (2D)-expansion. Such a result is typical for the ablation process determined by electron conductivity energy transfer under the conditions of one-dimensional or 2D matter expansion without any appreciable effect due to energy transfer by fast electrons. The 2D simulations based on application of the ALANT-HE code and an analytical model that includes generation and transport of hot electrons has been used to support of experimental data.

The effect of laser intensity on characteristics of the plasma ablated from a low-Z (CH) planar target irradiated by a 250 ps, 0.438 µm laser pulse with the intensity of up to 1016 W/cm2 as well as on parameters of the laser-driven shock generated in the target for various scale-lengths of preformed plasma was investigated at the kilojoule Prague Asterix Laser System (PALS) laser facility. Characteristics of the plasma were measured with the use of 3-frame interferometry, ion diagnostics, an X-ray spectrometer, and Kα imaging. Parameters of the shock generated in a Cl doped CH target by the intense 3ω laser pulse were inferred by numerical hydrodynamic simulations from the measurements of craters produced by the shock in the massive Cu target behind the CH layer. It was found that the pressure of the shock generated in the plastic layer is relatively weakly influenced by the preplasma (the pressure drop due to the preplasma presence is ~10–20%) and at the pulse intensity of ~1016 W/cm2 the maximum pressure reaches ~80–90 Mbar. However, an increase in pressure of the shock with the laser intensity is slower than predicted by theory for a planar shock and the maximum pressure achieved in the experiment is by a factor of ~2 lower than predicted by the theory. Both at the preplasma absence and presence, the laser-to-hot electrons energy conversion efficiency is small, ~1% or below, and the influence of hot electrons on the generated shock is expected to be weak.

This paper aims at investigation of efficiency of an ablative plasma energy transfer into a massive aluminum target using different atomic number ablators. For this reason, several target materials representing a wide range of atomic numbers (Z = 3.5–73) were used. The experiment was carried out at the iodine Prague Asterix Laser System. The laser provided a 250 ps pulse with energy of 130 J at the third harmonic frequency (λ3 = 0.438 μm). To study the plasma stream configurations a four-frame X-ray pinhole camera was used. The electron temperature of the plasma in the near-surface target region was measured by means of an X-ray spectroscopy. The efficiency of the plasma energy transport to the target was determined via the crater volume measurement using the crater replica technique. The experimental results were compared with two-dimensional numerical simulations where the plasma dynamics was based on the one-fluid, two temperature model, including radiation transport in diffusive approximation and ionization kinetics. It was shown that the plasma expansion geometry plays an important role in the ablative plasma energy transfer into the target.

This paper reports on properties of a plasma formed by sequential action of two laser beams on a flat target, simulating the conditions of shock-ignited inertial confinement fusion target exposure. The experiments were performed using planar targets consisting of a massive copper (Cu) plate coated with a thin plastic (CH) layer, which was irradiated by the 1ω PALS laser beam (λ = 1.315 μm) at the energy of 250 J. The intensity of the fixed-energy laser beam was scaled by varying the focal spot radius. To imitate shock ignition conditions, the lower-intensity auxiliary 1ω beam created CH-pre-plasma which was irradiated by the main beam with a delay of 1.2 ns, thus generating a shock wave in the massive part of the target. To study the parameters of the plasma treated by the two-beam irradiation of the targets, a set of various diagnostics was applied, namely: (i) Two-channel polaro-interferometric system irradiated by the femtosecond laser (~40 fs), (ii) spectroscopic measurements in the X-ray range, (iii) two-dimensional (2D)-resolved imaging of the Kα line emission from Cu, (iv) measurements of the ion emission by means of ion collectors, and (v) measurements of the volume of craters produced in a massive target providing information on the efficiency of the laser energy transfer to the shock wave. The 2D numerical simulations have been used to support the interpretation of experimental data. The general conclusion is that the fraction of the main laser beam energy deposited into the massive copper at two-beam irradiation decreases in comparison with the case of pre-plasma. The reason is that the pre-formed and expanding plasma deteriorates the efficiency of the energy transfer from the main laser pulse to a solid part of the targets by means of the fast electrons and the wave of an electron thermal conductivity.

The paper is directed to the study of high-temperature plasma and ablation plasma formation as well as efficiency of the laser energy transfer to solid targets irradiated by laser pulses with intensities of 1–50 PW/cm2 and duration of 200–300 ps, i.e., at conditions corresponding to the characteristics of the laser spike designed to generate the igniting shock wave in the shock ignition concept. The experiments have been performed at Prague Asterix Laser System. The iodine laser delivered 250 ps (full width at half maximum) pulses with the energy in the range of 100–600 J at the first (λ1 = 1.315 µm) and third (λ3 = 0.438 µm) harmonic frequencies. The focal spot radius of the laser beam on the surface of Al or Cu targets made was gradually decreased from 160 to 40 µm. The diagnostic data collected using three-frame interferometry, X-ray spectroscopy, and crater replica technique were interpreted by two-dimensional numerical and analytical modeling which included generation and transport of fast electrons. The coupling parameter Iλ2 was varied in the range of 1 × 1014−8 × 1016 Wμm2/cm2 covering the regimes of weak to intense fast electron generation. The dominant contribution of fast electron energy transfer into the ablation process and shock wave generation was found when using the first harmonic laser radiation, the focal spot radius of 40–100 µm, and the laser energy of 300–600 J.

Jets of laser–generated plasma represent a flexible and well-defined model environment for investigation of plasma interactions with solid surfaces (walls). The pilot experiments carried out on the iodine laser system (5–200 J, 0.44 µm, 0.25–0.3 ns, <1×1016 W/cm2) at the PALS Research Centre in Prague are reported. Modification of macroscopic characteristics of the Al plasma jets produced at laser-irradiated double-foil Al/Mg targets is studied by high-resolution, high-dispersion X-ray spectroscopy. The spatially variable, complex satellite structure observed in emission spectra of the Al Lyα group proves a formation of rather cold dense plasma at the laser-exploded Al foil, an occurrence of the hot plasma between both foils and subsequent thermalization, deceleration and trapping of Al ions in the colliding plasma close to the Mg foil surface. The spectra interpretation based on the collisional-radiative code is complemented by 1D and 2D hydrodynamic modeling of the plasma expansion and interaction of counter-propagating Al/Mg plasmas. The obtained results demonstrate a potential of high resolution X-ray diagnostics in investigation of the laser-produced plasma–wall interactions.

Vertical dispersion variant of the double-crystal spectrograph is analyzed and its basic quantitative characteristics (luminosity, resolving power) are computed using ray tracing code. It is shown that geometric apparatus smearing is minimized due to high dispersion and spectral resolution may considerably exceed the single-crystal diffraction limit. Performing high-resolution spectral work, the efficiency of the double-crystal apparatus exceeds that of the flat single-crystal spectrograph. The usefulness of this method in laser plasma spectroscopy is demonstrated analyzing the detection of phosphorus He-like resonance line and its satellites.

The first harmonics beam generated by an iodine laser system was focused by an f/2 optics on an Al foil target. The X-ray output from the laser plasma both in the line and broad-band spectra was registered over an interval around the “ideal” focus. It was found that the maximum X-ray power is not obtained in the focus itself but for a somewhat larger focal spot outside the focus. To explain this phenomena, temperature and density measurements were in addition made. The plasma temperature evaluated from both the line (He-like Al XII resonant line and j, k, l satellites) and broad-band spectra (two foil method) was also measured and found to be largely constant in the vicinity of the focus. The line and broad-band temperatures differ, the broad-band temperature being about 25% higher. The electron density was equally determined using an intercombination line.

A vertical dispersion variant of the Johann spectrometer has been used to record the highresolution X-ray spectra of the chlorine He-like resonance line group emitted from lowradiance plasma. The emission profiles were measured at two observation angles and decomposed into single spectral lines by using a fit based on the Levenberg-Marquardt algorithm. The results of computerized analysis of the one-dimensional (1-D) spatially resolved spectra were used to evaluate the distribution of the main plasma parameters. The electron temperature gradient 7.5·104 eV cm-1 was computed by modeling the measured spectra with the collisional-radiative package RATION. The blowoff maximum velocities 4.2–6.1·107 cm s-1 and the velocity gradients 0.9–1.6·109 s-1 were determined from the Doppler shifts of individual spectral lines within their different spatial extent.

Two novel high-dispersion, high-resolution spectroscopic methods are described. The properties of the vertical dispersion variants of the double-crystal spectrometer and the Johann spectrometer with a cylindrically bent crystal are discussed and compared with those of standard spectroscopic schemes. Preliminary experimental data demonstrate the good luminosity and extreme spectral and 1-D spatial resolution of these methods, which should prove useful in high-precision X-ray spectroscopic measurements of laser-produced plasmas.

Zinc deficiency is common among the elderly and has been associated with oxidative stress, immune dysfunction and CVD. We examined whether low zinc concentrations are associated with total, cardiovascular and non-cardiovascular mortality. Serum zinc concentrations were measured in 3316 patients from the Ludwigshafen Risk and Cardiovascular Health study, who were routinely referred to coronary angiography at a single tertiary care centre in Southwest Germany. After a median follow-up period of 7·75 years, 769 patients had died, including 484 deaths due to cardiovascular and 261 due to non-cardiovascular causes. After adjustments for cardiovascular risk factors and other possible confounders, the hazard ratios in the first when compared with the fourth zinc quartile, and per quartile decrease were 1·44 (95 % CI 1·13, 1·83; P = 0·001) and 1·15 (95 % CI 1·07, 1·24; P < 0·001) for total mortality, 2·20 (95 % CI 1·42, 3·42; P < 0·001) and 1·32 (95 % CI 1·16, 1·50; P < 0·001) for non-cardiovascular mortality and 1·24 (95 % CI 0·92, 1·66; P = 0·162) and 1·10 (95 % CI 1·01, 1·21; P = 0·038) for cardiovascular mortality. Furthermore, serum zinc concentrations correlated negatively with age and markers of inflammation and positively with antioxidants. The present results suggest that zinc deficiency may contribute to a reduced life expectancy in patients scheduled for coronary angiography.

The aim of the reported research is to contribute to investigation of new processes and methods interlinking nuclear and laser-plasma physics. With respect to requirements of nuclear experiments at medium-size high-power lasers, the selection of proper candidates for studying the excitation and decay of low-lying nuclear states is reviewed. An experimental approach to the identification of low-energy nuclear transitions is discussed, simple estimates of the 181Ta excitation yield in the laser-generated plasma provide a theoretical basis for planning future work. First tests and results of the experiments at the laser facility PALS are presented.

After resective and reconstructive surgery in the gastrointestinal tract, oral feeding is traditionally avoided in order to minimize strain to the anastomoses and to reduce the inherent risks of the postoperatively impaired gastrointestinal motility. However, studies have given evidence that the small bowel recovers its ability to absorb nutrients almost immediately following surgery, even in the absence of peristalsis, and that early enteral feeding would preserve both the integrity of gut mucosa and its immunological function. The aim of this study was to investigate the impact of early enteral feeding on the postoperative course following oesophagectomy or oesophagogastrectomy, and reconstruction. Between May 1999 and November 2002, forty-four consecutive patients (thirty-eight males and six females; mean age 62, range 30–82) with oesophageal carcinoma (stages I–III), who had undergone radical resection and reconstruction, entered this study (early enteral feeding group; EEF). A historical group of forty-four patients (thirty-seven males and seven females; mean age 64, range 41–79; stages I–III) resected between January 1997 and March 1999 served as control (parenteral feeding group; PF). The duration of both postoperative stay in the Intensive Care Unit (ICU) and the total hospital stay, perioperative complications and the overall mortality were compared. Early enteral feeding was administered over the jejunal line of a Dobhoff tube. It started 6 h postoperatively at a rate of 10 ml/h for 6 h with stepwise increase until total enteral nutrition was achieved on day 6. In the controls oral enteral feeding was begun on day 7. If compared to the PF group, EEF patients recovered faster considering the duration of both stay in the ICU and in the hospital. There was a significant difference in the interval until the first bowel movements. No difference in overall 30 d mortality was identified. A poor nutritional status was a significant prognostic factor for an increased mortality. Early enteral feeding significantly reduces the duration of ICU treatment and total hospital stay in patients who undergo oesophagectomy or oesophagogastrectomy for oesophageal carcinoma. The mortality rate is not affected.

Soft X-ray contact microscopy (SXCM) experiments have been performed using the Prague Asterix Iodine Laser System (PALS). Laser wavelength and pulse duration were λ = 1.314 μm and τ (FWHM) = 450 ps, respectively. Pulsed X rays were generated using teflon, gold, and molybdenum targets with laser intensities I ≥ 1014 W/cm2. Experiments have been performed on the nematodes Caenorhabditis elegans. Images were recorded on PMMA photo resists and analyzed using an atomic force microscope operating in contact mode. Our preliminary results indicate the suitability of the SXCM for multicellular specimens.

Modern experimental methods and instruments for X-ray spectral investigation of hot dense plasma provide complex information on environmental conditions in extreme states of matter. The basic spectroscopic conceptions for K-shell plasma diagnosis are outlined, the main characteristics of toroidally bent crystal spectrometers and vertical-dispersion instruments are briefly reviewed. Selected applications (monitoring and optimization of the emission from the femtosecond-laser-produced plasmas, characterization of colliding laser-exploded foils, spectral line merging, and continuum lowering in constrained-flow plasmas) demonstrate the usefulness of advanced spectroscopic methods for plasma diagnostics and fundamental research.