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Clinical practice guidelines for schizophrenia and major depressive disorder have been published. However, these have not had sufficient penetration in clinical settings. We developed the Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE) project as a dissemination and education programme for psychiatrists.
The aim of this study is to assess the effectiveness of the EGUIDE project on the subjective clinical behaviour of psychiatrists in accordance with clinical practice guidelines before and 1 and 2 years after participation in the programmes.
A total of 607 psychiatrists participated in this study during October 2016 and March 2019. They attended both 1-day educational programmes based on the clinical practice guidelines for schizophrenia and major depressive disorder, and answered web questionnaires about their clinical behaviours before and 1 and 2 years after attending the programmes. We evaluated the changes in clinical behaviours in accordance with the clinical practice guidelines between before and 2 years after the programme.
All of the scores for clinical behaviours in accordance with clinical practice guidelines were significantly improved after 1 and 2 years compared with before attending the programmes. There were no significant changes in any of the scores between 1 and 2 years after attending.
All clinical behaviours in accordance with clinical practice guidelines improved after attending the EGUIDE programme, and were maintained for at least 2 years. The EGUIDE project could contribute to improved guideline-based clinical behaviour among psychiatrists.
The surface of Ti-based bulk metallic glass (BMG) was irradiated by the femto-second laser and microgrooves were formed on the surface. The titanate nanomesh layers were fabricated on the micro-grooved BMG surface by hydrothermal-electrochemical (H-E) treatment changing the conditions of the concentration of electrolyte solution (0 and 5 M) and applying current density (0-200 mA/cm2). The bone-inducing capacity of the samples with different H-E treatment was confirmed by soaking them in a simulated body fluid for 12 days. The H-E treatment in higher concentration 5 M NaOH aq. and applying higher current density above 0.5 mA/cm2 exhibited excellent bioactivity inducing large hydroxyapatite crystallites.
A Cu- and Ni-free Zr-based metallic glass with high glass-forming ability was found in the Zr-Al-Co ternary system. The eutectic Zr56Al16Co28 alloy could be cast into glassy cylindrical rods with diameters up to 18 mm. The glassy alloy exhibited high tensile fracture strength of 1830 MPa and low Young's modulus of 83 GPa in conjunction with better corrosion resistance compared with the glassy Zr57Nb5Al10Ni12.6Cu15.4 in a simulated body fluid. Hydrothermal-electrochemical treatment in the aqueous 5M-NaOH solution resulted in the formation of amorphous sodium cobaltate layer on the surface of glassy Zr56Al16Co28 alloy. Hydroxyapatite was spontaneously formed on the surface of the alloy, indicating bioactivity after surface modification. The discovery of a Cu- and Ni-free Zr-based metallic glass with a critical diameter larger than 1 cm in conjunction with excellent mechanical properties, superior corrosion resistance, and good bioactivity may open up the application field as biomaterials.
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