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The male reproductive system is a complex network of central nervous system circuits and internal and external pelvic organs. The hypothalamic–pituitary–gonadal (HPG) axis leads to reproductive tract formation and development during embryogenesis, sexual maturation at puberty, and testosterone and sperm production by the testis as an adult. Spermatogenesis is regulated by pulsatile secretions of GnRH, LH, and FSH and feedback regulation on the HPG axis. Immotile spermatozoa are produced within the seminiferous tubules of the testis. During transport through the epididymis, sperm undergo the maturation processes to induce motility and subsequent fertility. Sperm are transported through the ejaculatory ducts and into the urethra during ejaculation, combining with the seminal fluid that provides a nutrient-rich environment, assists in sperm motility, and suppresses the immune response in the female reproductive tract.
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