An analysis of Leo Strauss's difficult and relatively neglected criticism of Max Weber in Natural Right and History reveals the fundamental difficulties that political science, and social science more generally, must overcome in order to be a genuine science. In Strauss's view, the inadequacy of the fact-value distinction, which is now widely acknowledged, compels a re-examination of Weber's denial of the possibility of valid knowledge of values. Strauss identifies the serious ground of this denial as Weber's insight that modern philosophy or science cannot refute religion. Believing that philosophy or science cannot ultimately give an account of itself that meets the challenge of religion, Weber maintained a “tragic” view of the human situation. Strauss also expresses profound doubt about the possibility of philosophy or science, but ultimately he suggests that a certain kind of study of the history of political philosophy might resolve the conflict between philosophy and divine revelation, and, therewith, the “value problem.”