A famous problem in birational geometry is to determine when the birational automorphism group of a Fano variety is finite. The Noether–Fano method has been the main approach to this problem. The purpose of this paper is to give a new approach to the problem by showing that in every positive characteristic, there are Fano varieties of arbitrarily large index with finite (or even trivial) birational automorphism group. To do this, we prove that these varieties admit ample and birationally equivariant line bundles. Our result applies the differential forms that Kollár produces on $p$-cyclic covers in characteristic $p > 0$.

Exposure to maternal hyperglycemia in utero has been associated with adverse metabolic outcomes in offspring. However, few studies have investigated the relationship between maternal hyperglycemia and offspring cortisol levels. We assessed associations of gestational diabetes mellitus (GDM) with cortisol biomarkers in two longitudinal prebirth cohorts: Project Viva included 928 mother–child pairs and Gen3G included 313 mother–child pairs. In Project Viva, GDM was diagnosed in N = 48 (5.2%) women using a two-step procedure (50 g glucose challenge test, if abnormal followed by 100 g oral glucose tolerance test [OGTT]), and in N = 29 (9.3%) women participating in Gen3G using one-step 75 g OGTT. In Project Viva, we measured cord blood glucocorticoids and child hair cortisol levels during mid-childhood (mean (SD) age: 7.8 (0.8) years) and early adolescence (mean (SD) age: 13.2 (0.9) years). In Gen3G, we measured hair cortisol at 5.4 (0.3) years. We used multivariable linear regression to examine associations of GDM with offspring cortisol, adjusting for child age and sex, maternal prepregnancy body mass index, education, and socioeconomic status. We additionally adjusted for child race/ethnicity in the cord blood analyses. In both Project Viva and Gen3G, we observed null associations of GDM and maternal glucose markers in pregnancy with cortisol biomarkers in cord blood at birth (β = 16.6 nmol/L, 95% CI −60.7, 94.0 in Project Viva) and in hair samples during childhood (β = −0.56 pg/mg, 95% CI −1.16, 0.04 in Project Viva; β = 0.09 pg/mg, 95% CI −0.38, 0.57 in Gen3G). Our findings do not support the hypothesis that maternal hyperglycemia is related to hypothalamic–pituitary–adrenal axis activity.

This survey explored access to British Columbia (BC) hospital-based neurorehabilitation outpatient programs (HB-NROPs). Fifteen rehabilitation-focused healthcare providers were interviewed. Wait times for HB-NROPs were up to 3 months for initial appointments, and inclusion criteria were variable. Two HB-NROPs had occasional access to specialized physicians. Informal communication methods were preferred modes of collaboration. BC HB-NROPs varied in access, use of interdisciplinary care, and outcome measures used to measure performance. The lack of coverage for nonphysician services may be a barrier to collaborative care in the community. Future projects should explore solutions to improve funding and equal access to BC HB-NROPs.

Gravitational waves from coalescing neutron stars encode information about nuclear matter at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced by the presence of tides, which depend on the neutron star equation of state. Neutron star mergers are expected to often produce rapidly rotating remnant neutron stars that emit gravitational waves. These will provide clues to the extremely hot post-merger environment. This signature of nuclear matter in gravitational waves contains most information in the 2–4 kHz frequency band, which is outside of the most sensitive band of current detectors. We present the design concept and science case for a Neutron Star Extreme Matter Observatory (NEMO): a gravitational-wave interferometer optimised to study nuclear physics with merging neutron stars. The concept uses high-circulating laser power, quantum squeezing, and a detector topology specifically designed to achieve the high-frequency sensitivity necessary to probe nuclear matter using gravitational waves. Above 1 kHz, the proposed strain sensitivity is comparable to full third-generation detectors at a fraction of the cost. Such sensitivity changes expected event rates for detection of post-merger remnants from approximately one per few decades with two A+ detectors to a few per year and potentially allow for the first gravitational-wave observations of supernovae, isolated neutron stars, and other exotica.

We show that complex Fano hypersurfaces can have arbitrarily large degrees of irrationality. More precisely, if we fix a Fano index $e$, then the degree of irrationality of a very general complex Fano hypersurface of index $e$ and dimension n is bounded from below by a constant times $\sqrt{n}$. To our knowledge, this gives the first examples of rationally connected varieties with degrees of irrationality greater than 3. The proof follows a degeneration to characteristic $p$ argument, which Kollár used to prove nonrationality of Fano hypersurfaces. Along the way, we show that in a family of varieties, the invariant ‘the minimal degree of a dominant rational map to a ruled variety’ can only drop on special fibers. As a consequence, we show that for certain low-dimensional families of varieties, the degree of irrationality also behaves well under specialization.

In 2018, the Alliance for Open Media (AOMedia) finalized its first video compression format AV1, which is jointly developed by the industry consortium of leading video technology companies. The main goal of AV1 is to provide an open source and royalty-free video coding format that substantially outperforms state-of-the-art codecs available on the market in compression efficiency while remaining practical decoding complexity as well as being optimized for hardware feasibility and scalability on modern devices. To give detailed insights into how the targeted performance and feasibility is realized, this paper provides a technical overview of key coding techniques in AV1. Besides, the coding performance gains are validated by video compression tests performed with the libaom AV1 encoder against the libvpx VP9 encoder. Preliminary comparison with two leading HEVC encoders, x265 and HM, and the reference software of VVC is also conducted on AOM's common test set and an open 4k set.

All-inkjet-printed organic thin-film transistors take advantage of low-cost fabrication and high compatibility to large-area manufacturing, making them potential candidates for flexible, wearable electronics. However, in real-world applications, device instability is an obstacle, and thus, understanding the factors that cause instability becomes compelling. In this work, all-inkjet-printed low-voltage organic thin-film transistors were fabricated and their stability was investigated. The devices demonstrate low operating voltage (<3 V), small subthreshold slope (128 mV/decade), good mobility (0.1 cm2 V−1 s−1), close-to-zero threshold voltage (−0.16 V), and high on/off ratio (>105). Several aspects of stability were investigated, including mechanical bending, shelf life, and bias stress. Based on these tests, we find that water molecule polarization in dielectrics is the main factor causing instability. Our study suggests use of a printable water-resistant dielectric for stability enhancement for the future development of all-inkjet-printed organic thin-film transistors.

Behavioral inhibition (BI) is a temperament identified in early childhood that is associated with risk for anxiety disorders, yet only about half of behaviorally inhibited children manifest anxiety later in life. We compared brain function and behavior during extinction recall in a sample of nonanxious young adults characterized in childhood with BI (n = 22) or with no BI (n = 28). Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. While self-report and psychophysiological measures of differential conditioning and extinction were similar across groups, BI-related differences in brain function emerged during extinction recall. Childhood BI was associated with greater activation in subgenual anterior cingulate cortex in response to cues signaling safety. This pattern of results may reflect neural correlates that promote resilience against anxiety in a temperamentally at-risk population.

TiO2 has attracted tremendous research interest for photocatalytic water splitting, solar hydrogen generation, environmental pollution removal, dye-sensitized solar cells, lithium-ion batteries, supercapacitors, and field emission. Microwave absorption materials (MAMs) play important roles in many military (e.g., the stealth coating on the B-2 bomber) and civil (e.g., telecommunications, noise reduction, information security, signal, and data protection) applications. However, TiO2 is not a good MAM due to its poor absorption in the microwave region. Here, we report that via hydrogenation excellent and tunable microwave absorption is achieved with hydrogenated TiO2 nanocrystals. After hydrogenation, 4.3x and 103x improvements have been obtained in storing and dissipating the electric energy of the microwave electromagnetic field. Their permittivity values are higher than those of the current carbonaceous MAMs. Instead of relying on the dipole rotation or ferromagnetic resonance mechanisms for traditional MAMs, the hydrogenated TiO2 nanocrystals work as good MAMs based on a newly proposed collective-movement-of-interfacial-dipole (CMID) mechanism. Although there is still no direct physical evidence of the interface effects of the CMID mechanism, the CMID as a hypothesis at this point successfully explained the origin of the enhanced microwave absorption of the hydrogenated TiO2 nanoparticles. This study thus may open new applications for TiO2 nanocrystals and also stimulate new approaches for new MAM development.

massMobile is a client-server system for large audience participation in live performances using mobile devices. It allows for rapid development, deployment and iterative experimentation in participatory design, while minimising technical and logistical overhead. It was designed to flexibly adapt to a variety of participatory performance needs and to a variety of performance venues. It allows for real-time bi-directional communication between performers and audiences utilising existing 3G, 4G or WiFi networks. Audience members access massMobile through a smartphone-optimised web application utilising common web standards. An offsite server passes data between the audience and the performer(s) and stores the data for later analysis. In this paper, we discuss the goals, design and implementation of the framework, and we describe several projects realised with massMobile.

We prove that for a finitely generated infinite nilpotent group G with structure (G, ·, …), the connected component G*0 of a sufficiently saturated extension G* of G exists and equals

We construct an expansion of ℤ by a predicate (ℤ, +, P) such that the type-connected component is strictly smaller than ℤ*0. We generalize this to finitely generated virtually solvable groups. As a corollary of our construction we obtain an optimality result for the van der Waerden theorem for finite partitions of groups.