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We report on the simultaneous g′,r′,i′,z′ multiband, high time sampling (18-24s) ground-based photometric observations, which we use to measure the planetary radius and orbital inclination of the extrasolar transiting hot Jupiter WASP-4b. We recorded 987 images during three complete transits with the GROND instrument, mounted on the MPG/ESO-2.2m telescope at La Silla Observatory. Assuming a quadratic law for the stellar limb darkening we derive system parameters by fitting a composite transit light curve over all bandpasses simultaneously. To compute uncertainties of the fitted parameters we employ the Bootstrap Monte Carlo Method. The three central transit times are measured with precision down to 6 s. We find a planetary radius Rp = 1.413 ± 0.020RJup, an orbital inclination i = 88.°57 ± 0.45° and calculate new ephemeris, a period P = 1.33823144 ± 0.00000032 days and reference transit epoch T0 = 2454697.798311 ± 0.000046 (BJD). The analysis of the new transit mid-times in combination with previous measurements imply a constant orbital period and no compelling evidence for TTVs due to additional bodies in the system.
Psychiatric phenotypes are currently defined according to sets of
descriptive criteria. Although many of these phenotypes are heritable, it
would be useful to know whether any of the various diagnostic categories
in current use identify cases that are particularly helpful for
To use genome-wide genetic association data to explore the relative
genetic utility of seven different descriptive operational diagnostic
categories relevant to bipolar illness within a large UK case–control
bipolar disorder sample.
We analysed our previously published Wellcome Trust Case Control
Consortium (WTCCC) bipolar disorder genome-wide association data-set,
comprising 1868 individuals with bipolar disorder and 2938 controls
genotyped for 276 122 single nucleotide polymorphisms (SNPs) that met
stringent criteria for genotype quality. For each SNP we performed a test
of association (bipolar disorder group v. control group) and used the
number of associated independent SNPs statistically significant at
P<0.00001 as a metric for the overall genetic
signal in the sample. We next compared this metric with that obtained
using each of seven diagnostic subsets of the group with bipolar
disorder: Research Diagnostic Criteria (RDC): bipolar I disorder; manic
disorder; bipolar II disorder; schizoaffective disorder, bipolar type;
DSM–IV: bipolar I disorder; bipolar II disorder; schizoaffective
disorder, bipolar type.
The RDC schizoaffective disorder, bipolar type (v.
controls) stood out from the other diagnostic subsets as having a
significant excess of independent association signals
(P<0.003) compared with that expected in samples of
the same size selected randomly from the total bipolar disorder group
data-set. The strongest association in this subset of participants with
bipolar disorder was at rs4818065 (P = 2.42 ×
10–7). Biological systems implicated included gamma
amniobutyric acid (GABA)A receptors. Genes having at least one
associated polymorphism at P<10–4 included
B3GALTS, A2BP1, GABRB1, AUTS2, BSN, PTPRG, GIRK2 and
Our findings show that individuals with broadly defined bipolar
schizoaffective features have either a particularly strong genetic
contribution or that, as a group, are genetically more homogeneous than
the other phenotypes tested. The results point to the importance of using
diagnostic approaches that recognise this group of individuals. Our
approach can be applied to similar data-sets for other psychiatric and
We investigate nonlinear resonances and the averaged potential in a bounded non-isothermal plasma, placed in a constant magnetic field and a parallel external a.c. electric field. The treatment assumes one component MHD. It is assumed that a standing Alfvén wave exists before the electric field is switched on.
Resonance frequencies of a plane plasma condenser in crossed electric and magnetic fields are determined, using the two-component magnetic hydrodynamical equations. The perturbed plasma parameters (ion and electron densities and velocities and the electric field in the plasma), due to an external a.c. electric field are found. The calculated resonance is not exact since dissipative processes are neglected.
In this paper we present a novel method of nonlinear macro model of a cantilever for mixed domain simulation only with SPICE. Based on lumped elements of equivalent circuits a model is developed, which realizes a coupled electro-thermal-mechanical simulation including crosstalk effects. The model is verified with measurement and helps to class and solve crosstalk. With SPICE as electrical circuit simulator the cantilever array could be simulate in conjunction with the excitations and analysis electronics more detailed like the system level models and faster like FEM-simulation.
Velo-cardio-facial syndrome (VCFS) is associated with interstitial deletions of chromosome 22q11. About 30% of patients with VCFS have psychosis, and the rate of these deletions in schizophrenia has been reported to be about 1%. Even higher rates of VCFS deletions have been reported for childhood-onset schizophrenia.
To test the hypothesis that there is an increased rate of VCFS among patients with early-onset psychosis (age at onset < 18 years). We screened 192 early-onset patients and 329 patients with adult-onset schizophrenia.
We genotyped the patients and 444 healthy controls for hemizygosity of five microsatellite markers and one single nucleotide polymorphism that map to the 22q11-deleted region.
One patient had a VCFS deletion, confirmed with semi-quantitative polymerase chain reaction. None of the controls showed a pattern of genotypes consistent with hemizygosity.
VCFS may be less frequent among patients with psychosis than previously suggested; this rate is not increased among early-onset patients.
A nonlinear relaxation is observed when an electron beam interacts with plasma in an external magnetic field. An acceleration of electrons to energies which are more than twice that of the initial beam energy is observed. The acceleration mechanism is connected with the modulation instability of the plasma waves which is excited when the beam relaxes.
About twenty years ago van den Bergh (1964) recognized 188 OB associations in the Andromeda Nebula. He used plates taken by the 52-inches Tautenburgh Schmidt telescope in GDR. Later on Richter (1971) added 7 new associations in the south-western periphery of M31. Now we have the opportunity to continue the search of stellar associations in M31 with the 2m Ritchey-Chrétien (RC) telescope of the Bulgarian National Astronomical Observatory. The limiting magnitude of this telescope is approximately the same as that of the Tautenburg 2m Schmidt telescope but it possesses somewhat smaller field (1°x1°) with plate-scale 12.8 mm−1. That is why a new search of stellar associations in M31 by means of the 2m RC telescope is very efficient. Indeed, some previous inspections of the RC plates (Efremov, 1982) indicated some new associations in M31.
Using rich photometric material on the Cepheids in the Galaxy and the Large and Small Magellanic Clouds, the structure of the instability strip in the HR diagram is investigated. The method of the δ-δ diagrams is used, δ being the difference of certain Cepheid characteristics from the means for a given period. The Cepheids in the three galaxies, studied separately, show the same relationship: the light amplitude increases toward the low temperature limit of the instability strip and is also related with the temperature at maximum in the sense that Cepheids with a given period and fixed mean temperature have a greater light amplitude for a higher temperature at maximum. Our results do not coincide with those by Sandage and Tammann, probably because they have studied the Cepheids in the different star systems as one single complex.
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