To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Background. In bulimic syndromes, binge episodes are thought to be caused by dietary restraint and negative moods. However, as central serotonin (5-hydroxytryptamine: 5-HT) mechanisms regulate appetite and mood, the 5-HT system could be implicated in diet- and mood-based binge antecedents.
Method. We used hand-held computers to obtain repeated ‘online’ measurements of eating behaviors, moods, and self-concepts in 21 women with bulimic syndromes, and modeled 5-HT system activity with a measure of platelet [3H]paroxetine-binding density.
Results. Mood and self-concept ratings were found to be worse before binge episodes (than at other moments), and cognitive restraint was increased. After binges, mood and self-concept deteriorated further, and thoughts of dieting became more intense. Intriguingly, lower paroxetine-binding density predicted poorer mood and self-concept before a binge, larger post-binge decrements in mood and self-concept, and larger post-binge increases in dietary restraint.
Conclusions. Paroxetine binding thus seemed to reflect processes that impacted upon mood-related antecedents to binge episodes, and consequences implicating mood and dietary restraint.
Background. Bulimic, impulsive and depressive syndromes have all been associated with
abnormalities in brain serotonin (5-hydroxytryptamine; 5-HT) mechanisms.
Methods. We had 26 bulimic women and 22 normal-eater women report impulsive, affective, self-destructive
and bulimic symptoms, and then provide serial blood samples for measurement of: [3H]-paroxetine
binding in platelets; and, prolactin (PRL) responses following oral meta-chlorophenyl-piperazine (m-CPP).
Results. Bulimic status was associated with markedly reduced density of paroxetine-binding sites,
modest blunting of m-CPP stimulated PRL response, and greater nausea following m-CPP.
Biological variables did not co-vary with most psychopathological or eating-symptom indices.
However, there were inverse associations (in bulimic women only) between scores indicating
impulsivity (largely ‘unreflectiveness’) and density of platelet 5-HT uptake sites.
Conclusions. Our observations link bulimia nervosa to altered 5-HT functioning, and suggest that
there may be a relatively symptom-specific association between impulsivity and reduced 5-HT
Email your librarian or administrator to recommend adding this to your organisation's collection.