Large research teams and consortia present challenges for authorship. The number of disciplines involved in the research can further complicate approaches to manuscript development and leadership. The CHARM team, representing a multi-disciplinary, multi-institutional genomics implementation study, participated in facilitated discussions inspired by team science methodologies. The discussions were centered on team members’ past experiences with authorship and perspectives on authorship in a large research team context. Team members identified challenges and opportunities that were used to create guidelines and administrative tools to support manuscript development. The guidelines were organized by the three values of equity, inclusion, and efficiency and included eight principles. A visual dashboard was created to allow all team members to see who was leading or involved in each paper. Additional tools to promote equity, inclusion, and efficiency included providing standardized project management for each manuscript and making “concept sheets” for each manuscript accessible to all team members. The process used in CHARM can be used by other large research teams and consortia to equitably distribute lead authorship opportunities, foster coauthor inclusion, and efficiently work with large authorship groups.

This article describes a novel approach to the control of a powered knee prosthesis where the control system provides passive behavior for most activities and then provides powered assistance only for those activities that require them. The control approach presented here is based on the categorization of knee joint function during activities into four behaviors: resistive stance behavior, active stance behavior, ballistic swing, and non-ballistic swing. The approach is further premised on the assumption that healthy non-perturbed swing-phase is characterized by a ballistic swing motion, and therefore, a replacement of that function should be similarly ballistic. The control system utilizes a six-state finite-state machine, where each state provides different constitutive behaviors (concomitant with the four aforementioned knee behaviors) which are appropriate for a range of activities. Transitions between states and torque control within states is controlled by user motion, such that the control system provides, to the extent possible, knee torque behavior as a reaction to user motion, including for powered behaviors. The control system is demonstrated on a novel device that provides a sufficiently low impedance to enable a strictly passive ballistic swing-phase, while also providing sufficiently high torque to offer powered stance-phase knee-extension during activities such as step-over stair ascent. Experiments employing the knee and control system on an individual with transfemoral amputation are presented that compare the functionality of the power-supplemented nominally passive system with that of a conventional passive microprocessor-controlled knee prosthesis.

Inflammatory bowel disease (IBD) is a group of immune-mediated disorders characterised by a chronic, relapsing-remitting inflammation predominantly affecting the gastrointestinal tract. IBD is incurable, affecting people in their most productive years. IBD is historically seen as a disease of Westernised nations although in recent times other countries have seen an exponential rise in cases. Although the exact pathogenesis remains unclear, evidence suggests that microbiota changes play a critical role in IBD pathogenesis. Over the past two decades, IBD has become one of the most studied human conditions linked to the gut microbiota. However, deciphering the intricate link between the gut microbiota and therapeutic efficacy remains elusive. This review will summarise the current evidence relating to the gut microbiota and its involvement in IBD pathogenesis as well as the impact of IBD treatments including pharmaceutical-, nutraceutical- and microbial-focused regimens on the gut microbiota.

Recent work in structure–processing relationships of polymer semiconductors have demonstrated the versatility and control of thin-film microstructure offered by meniscus-guided coating (MGC) techniques. Here, we analyze the qualitative and quantitative aspects of solution shearing, a model MGC method, using coating blades augmented with arrays of pillars. The pillars induce local regions of high strain rates—both shear and extensional—not otherwise possible with unmodified blades, and we use fluid mechanical simulations to model and study a variety of pillar spacings and densities. We then perform a statistical analysis of 130 simulation variables to find correlations with three dependent variables of interest: thin-film degree of crystallinity and transistor field-effect mobilities for charge-transport parallel (μpara) and perpendicular (μperp) to the coating direction. Our study suggests that simple fluid mechanical models can reproduce substantive correlations between the induced fluid flow and important performance metrics, providing a methodology for optimizing blade design.

Snow accumulation is an important component of the mass balance of alpine glaciers. To improve our understanding of the processes related to accumulation and their representation in state-of-the-art mass-balance models, extensive field measurements are required. We present measurements of snow accumulation distribution on Findelengletscher, Switzerland, for April 2010 using (1) in situ snow probings, (2) airborne ground-penetrating radar (GPR) and (3) differencing of two airborne light detection and ranging (lidar) digital elevation models (DEMs). Calculating high-resolution snow depth from DEM-differencing requires careful correction for vertical ice-flow velocity and densification in the accumulation area. All three methods reveal a general increase in snow depth with elevation, but also a significant small-scale spatial variability. Lidar-differencing and in situ snow probings show good agreement for the mean specific winter balance (0.72 and 0.78 m w.e., respectively). The lidar-derived distributed snow depth reveals significant zonal correlations with elevation, slope and curvature in a multiple linear regression model. Unlike lidar-differencing, GPR-derived snow depth is not affected by glacier dynamics or firn compaction, but to a smaller degree by snow density and liquid water content. It is thus a valuable independent data source for validation. The simultaneous availability of the three datasets facilitates the comparison of the methods and contributes to a better understanding of processes that govern winter accumulation distribution on alpine glaciers.

This research examines the extent to which negative attitudes toward African Americans influence public reactions to restoring political rights to felons. We argue that race-neutral policies, such as felon disenfranchisement laws, are non-separable from racial considerations, as images of criminals and felons are typically associated with Blacks. Such attitudes produce collateral consequences for felons, hampering the restoration of their full political rights and, ultimately, their citizenship. Predispositions, such as racial attitudes and political ideology, provide both racial and nonracial justifications for supporting these laws, yet, there are no empirical accounts of their relational effects on opinion toward felons’ rights. Using nationally representative survey data, we find that racialized resentment and ideology exert the most influence on the reactions to policies seeking political rights for felons as well as beliefs about the value of doing so. Consistent with much of the literature on attitudes toward ameliorative racial policies, higher levels of racial resentment strongly predict lower support for felons’ political rights among both conservatives and liberals, yet, racial resentment is most influential among liberals. Conservatives exhibit the highest levels of racial resentment, but its impact is depressed more by agreement on both racial attitudes and opposition to political rights of felons.