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This chapter considers the multiple and changing worldviews of Western Jewry in search of ontological and physical security in a post-enlightenment world of nation-states. Informed by a relational humanism, I interrogate the how different communities facing similar challenges developed different worldviews. The Introduction positions the paper in relationship to the other chapters in the volume, Section I explores the emergence of four different worldviews of western Jews from the beginning of the enlightenment through the early 20th century, and Section II considers the various events and processes that led the world’s two largest Jewish communities, the United States and Israel, to anchor themselves in two different worldviews.
Research on gender and politics is becoming increasingly mainstreamed within political science. To document this process, we introduce a comprehensive dataset of articles published in 37 political science journals through 2019 that can be considered “gender and politics” research. Whereas recent related literature has explored the descriptive representation of women in political science by examining authorship and citation patterns, we argue that the identification of publications substantively focused on gender and politics not only illuminates trends but also can contribute to broader conversations about substantive representation and methodological diversity in the discipline. This article highlights the theoretical challenges of identifying gender and politics research and analyzes major trends in the substantive representation of gender in the journals over time. This dataset is useful for scholars who are interested in the evolution of salient topics in gender and politics research and patterns of citation.
The decades since World War II have been characterized by distinct patterns of conflict and cooperation between US foreign policy and humanitarian organizations. This is, in many ways, predictable given their goals and what each wants from the other. American humanitarian organizations pledge a commitment to the idea of saving distant strangers in urgent, life-threatening circumstances. And just like all humanitarian organizations, they need two fundamental things to do so. Money, and lots of it. Assembling, transporting, distributing, administering, and overseeing the massive amounts of aid requires considerable money, material, and staff. They also need access to the affected populations. This access is mainly controlled by states and armed groups. In natural disasters this tends to be a minor challenge; governments and affected populations typically welcome any and all aid. Human-made disasters such as war, though, are an entirely different matter. Delivering aid in war zones is much less straightforward.
Adults who had non-edematous severe acute malnutrition (SAM) during infancy (i.e., marasmus) have worse glucose tolerance and beta-cell function than survivors of edematous SAM (i.e., kwashiorkor). We hypothesized that wasting and/or stunting in SAM is associated with lower glucose disposal rate (M) and insulin clearance (MCR) in adulthood.
We recruited 40 nondiabetic adult SAM survivors (20 marasmus survivors (MS) and 20 kwashiorkor survivors (KS)) and 13 matched community controls. We performed 150-minute hyperinsulinaemic, euglycaemic clamps to estimate M and MCR. We also measured serum adiponectin, anthropometry, and body composition. Data on wasting (weight-for-height) and stunting (height-for-age) were abstracted from the hospital records.
Children with marasmus had lower weight-for-height z-scores (WHZ) (−3.8 ± 0.9 vs. −2.2 ± 1.4; P < 0.001) and lower height-for-age z-scores (HAZ) (−4.6 ± 1.1 vs. −3.4 ± 1.5; P = 0.0092) than those with kwashiorkor. As adults, mean age (SD) of participants was 27.2 (8.1) years; BMI was 23.6 (5.0) kg/m2. SAM survivors and controls had similar body composition. MS and KS and controls had similar M (9.1 ± 3.2; 8.7 ± 4.6; 6.9 ± 2.5 mg.kg−1.min−1 respectively; P = 0.3) and MCR. WHZ and HAZ were not associated with M, MCR or adiponectin even after adjusting for body composition.
Wasting and stunting during infancy are not associated with insulin sensitivity and insulin clearance in lean, young, adult survivors of SAM. These data are consistent with the finding that glucose intolerance in malnutrition survivors is mostly due to beta-cell dysfunction.
Is humanitarianism a network, hierarchy, or market? This chapter argues that it combines principles of hierarchy and networks in the form of a club. It develops a sociologically inspired version of club governance to understand the rise and resilience of the Humanitarian Club. This sociological explanation illuminates how clubs, like many groups, are: distinguished by collective interests, identities, and values that create a common mentality and a sense of we-ness; and often generate a distinction from and feeling of superiority to outsiders. The chapter examines the structures of inequality and patterns of inclusion and exclusion, and traces the rise of the humanitarian elite and the creation of a Humanitarian Club that is produced and sustained by four kinds of capital and that create sharp distinctions between (Western) insiders who can deliver the goods and (Southern) outsiders who are viewed as inferior. Although the humanitarian field has attempted on countless occasions to create more inclusion and diversity, the chapter argues that these forms of capital guard the doors of the Club and maintain a humanitarian field in which Western aid organizations dominate Southern aid agencies.
Scholars in the twenty-first century increasingly describe a transformation in the architecture of global governance: from state-led international organizations to one of partnerships, networks, clubs, and layers populated by nongovernmental organizations, public–private partnerships, private organizations, corporations, and foundations. This introductory chapter tees up the core question for this edited volume: how do we understand these new architectures, and how do they reflect the changing relations between the actors involved in contemporary global governance? In order to better understand whether and how relations among the now myriad key actors have changed, it uses the lens of modes of governance, and focuses the analysis on three ideal-typical modes drawn from economic and sociological institutionalism. Hierarchical modes are characterized by top-down, centralized, organizational forms. Market modes are organized around non-hierarchical principles that regulate relatively independent actors. Network modes are characterized by relatively interdependent actors with a common purpose that voluntarily negotiate their rules through bargaining and persuasion. The chapter argues that the transformations in global governance are better understood not in terms of changes in actors but rather changes in relations among actors. It reviews the various forces behind the change, and emphasizes the necessity of examining both structures and preferences.
Global governance has come under increasing pressure since the end of the Cold War. In some issue areas, these pressures have led to significant changes in the architecture of governance institutions. In others, institutions have resisted pressures for change. This volume explores what accounts for this divergence in architecture by identifying three modes of governance: hierarchies, networks, and markets. The authors apply these ideal types to different issue areas in order to assess how global governance has changed and why. In most issue areas, hierarchical modes of governance, established after World War II, have given way to alternative forms of organization focused on market or network-based architectures. Each chapter explores whether these changes are likely to lead to more or less effective global governance across a wide range of issue areas. This provides a novel and coherent theoretical framework for analysing change in global governance. This title is available as Open Access on Cambridge Core.
Impaired olfaction may be a biomarker for early Lewy body disease, but its value in mild cognitive impairment with Lewy bodies (MCI-LB) is unknown. We compared olfaction in MCI-LB with MCI due to Alzheimer’s disease (MCI-AD) and healthy older adults. We hypothesized that olfactory function would be worse in probable MCI-LB than in both MCI-AD and healthy comparison subjects (HC).
Design:
Cross-sectional study assessing olfaction using Sniffin’ Sticks 16 (SS-16) in MCI-LB, MCI-AD, and HC with longitudinal follow-up. Differences were adjusted for age, and receiver operating characteristic (ROC) curves were used for discriminating MCI-LB from MCI-AD and HC.
Setting:
Participants were recruited from Memory Services in the North East of England.
Participants:
Thirty-eight probable MCI-LB, 33 MCI-AD, 19 possible MCI-LB, and 32HC.
Measurements:
Olfaction was assessed using SS-16 and a questionnaire.
Results:
Participants with probable MCI-LB had worse olfaction than both MCI-AD (age-adjusted mean difference (B) = 2.05, 95% CI: 0.62–3.49, p = 0.005) and HC (B = 3.96, 95% CI: 2.51–5.40, p < 0.001). The previously identified cutoff score for the SS-16 of ≤ 10 had 84% sensitivity for probable MCI-LB (95% CI: 69–94%), but 30% specificity versus MCI-AD. ROC analysis found a lower cutoff of ≤ 7 was better (63% sensitivity for MCI-LB, with 73% specificity vs MCI-AD and 97% vs HC). Asking about olfactory impairments was not useful in identifying them.
Conclusions:
MCI-LB had worse olfaction than MCI-AD and normal aging. A lower cutoff score of ≤ 7 is required when using SS-16 in such patients. Olfactory testing may have value in identifying early LB disease in memory services.
Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer’s disease (MCI-AD) and may anticipate the onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these etiologies. MCI patients (n = 92) and healthy comparators (n = 31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multistate transition model to account for death as a competing risk, while controlling for age, cognitive function, and etiology classified by an expert consensus panel.
Over a mean follow-up of 1.5 years (SD = 0.5), 14 cases of incident dementia and 5 deaths were observed. Increased theta/alpha ratio on qEEG was associated with increased annual hazard of dementia (hazard ratio = 1.84, 95% CI: 1.01–3.35). This extends previous findings that MCI-LB features early functional changes, showing that qEEG slowing may anticipate the onset of dementia in prospectively identified MCI.
Michael Zürn's Theory of Global Governance is an original, bold, and compelling argument regarding the causes of change in global governance. A core argument is that legitimation problems trigger changes in global governance. This contribution addresses two core features of the argument. Although I am persuaded that legitimacy matters, there are times when: legitimacy appears to be given too much credit to the relative neglect of other factors; other times when the lack of legitimacy has little discernible impact on the working of global governance; and unanswered questions about how the legitimacy of global governance relates to the legitimacy of the international order of which it is a part. The second feature is what counts as change in global governance. Zürn reduces change to either deepening or decline, overlooking the possible how of global governance. In contrast to Zürn's map of global governance that is dominated by hierarchies in the form of international organizations, an alternative map locates multiple modes of governance: hierarchies, markets, and networks. The kinds of legitimation problems that Zürn identifies, I argue, can help explain some of the movement from hierarchical to other modes of global governance.
Dopaminergic imaging is an established biomarker for dementia with Lewy bodies, but its diagnostic accuracy at the mild cognitive impairment (MCI) stage remains uncertain.
Aims
To provide robust prospective evidence of the diagnostic accuracy of dopaminergic imaging at the MCI stage to either support or refute its inclusion as a biomarker for the diagnosis of MCI with Lewy bodies.
Method
We conducted a prospective diagnostic accuracy study of baseline dopaminergic imaging with [123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computerised tomography (123I-FP-CIT SPECT) in 144 patients with MCI. Images were rated as normal or abnormal by a panel of experts with access to striatal binding ratio results. Follow-up consensus diagnosis based on the presence of core features of Lewy body disease was used as the reference standard.
Results
At latest assessment (mean 2 years) 61 patients had probable MCI with Lewy bodies, 26 possible MCI with Lewy bodies and 57 MCI due to Alzheimer's disease. The sensitivity of baseline FP-CIT visual rating for probable MCI with Lewy bodies was 66% (95% CI 52–77%), specificity 88% (76–95%) and accuracy 76% (68–84%), with positive likelihood ratio 5.3.
Conclusions
It is over five times as likely for an abnormal scan to be found in probable MCI with Lewy bodies than MCI due to Alzheimer's disease. Dopaminergic imaging appears to be useful at the MCI stage in cases where Lewy body disease is suspected clinically.
This essay uses COVID-19 to illuminate the sacrificial practices of the liberal international order as woven through the concepts of humanitarian governance, moral economy, triage, and sacrifice. The concept of a sacrificial international order calls attention to how all international orders have their share of sacrifices—and this includes liberal international orders. International orders can be distinguished by the selection mechanisms used to identify the sacrifices and the meanings attached to them. I call attention to how liberal international orders often rely on markets as a selection mechanism and interpret these deaths as part of progress. Following critical contributions to the study of neoliberalism that show how markets shape the ethics of “giving life” and “letting die,” I illuminate these processes through four concepts: humanitarian governance and the claim that the highest moral principle is saving lives and relieving suffering; moral economy that regulates who has access to basic subsistence goods during periods of crisis; triage, which considers how to prioritize whose lives are valued; and whether all deaths count as sacrifices or whether they are better understood as “those who can be killed.” I conclude by discussing how COVID-19 conjures hierarchies of humanity ignored by the liberal international order and challenges the discipline to consider the sacrifices in world order.