Here we present ground-penetrating radar measurements of Mittivakkat Gletscher, southeast Greenland, to estimate an empirical volume–area scaling relationship at an individual glacier. Between a previous direct volume survey in 1994 and one in 2012, the glacier volume has decreased from 2.02 km3 to 1.44 km3 while the study area has decreased from 17.6 km2 to 15.8 km2. These results are in accordance with the cumulative mass loss observed by long-term mass-balance measurements (1995/96–2011/12) at Mittivakkat Gletscher and confirm that the glacier is in severe climatic disequilibrium (AAR = 0.17). The observed scaling exponent γ = 3.14 and coefficient c = 0.00025 km3–2γ are outside the range of global scaling parameters but sensitive to small uncertainties. Nevertheless, existing global volume-area scaling relationships estimate the volume of Mittivakkat Gletscher within 31% and 15% of the measured 1994 and 2011 volumes, respectively.