Lake Vostok, East Antarctica, represents an extensive water surface at the base of the ice sheet. Snow, ice and atmospheric pressure loads applied anywhere within the lake area produce a hydrostatic response, involving deformations of the ice surface, ice–water interface and particle horizons. A modelling scheme is developed to derive height changes of these surfaces for a given load pattern. It is applied to a series of load scenarios, and predictions based on load fields derived from a regional climate model are compared to observational datasets. Our results show that surface height changes due to snow-buildup anomalies are damped over the lake area, reducing the spatial standard deviation by one-third. The response to air pressure variations, in turn, adds surface height variability. Atmospheric pressure loads may produce height changes of up to $\pm$4 cm at daily resolution, but decay rapidly with integration time. The hydrostatic load response has no significant impact neither on ICESat laser campaign biases determined over the lake area nor on vertical particle movements derived from GNSS observations.

Demographical and clinical characteristics have been reported to modulate the risk for suicide. This study analysed demographical and clinical characteristics with respect to lifetime suicide attempts in 500 individuals affected with schizophrenic or affective disorders. Suicide attempts were associated with poor premorbid social adjustment, low age at onset, low scores on the “Global Assessment Scale” and childlessness in females.

Background: The aim of this study was to assess the quality of reporting sample size calculation and underlying design assumptions in pivotal trials of high-risk medical devices (MDs) for neurological conditions.

Methods: Systematic review of research protocols for publicly registered randomized controlled trials (RCTs). In the absence of a published protocol, principal investigators were contacted for additional data. To be included, trials had to investigate a high-risk MD, registered between 2005 and 2015, with indications stroke, headache disorders, and epilepsy as case samples within central nervous system diseases. Extraction of key methodological parameters for sample size calculation was performed independently and peer-reviewed.

Results: In a final sample of seventy-one eligible trials, we collected data from thirty-one trials. Eighteen protocols were obtained from the public domain or principal investigators. Data availability decreased during the extraction process, with almost all data available for stroke-related trials. Of the thirty-one trials with sample size information available, twenty-six reported a predefined calculation and underlying assumptions. Justification was given in twenty and evidence for parameter estimation in sixteen trials. Estimates were most often based on previous research, including RCTs and observational data. Observational data were predominantly represented by retrospective designs. Other references for parameter estimation indicated a lower level of evidence.

Conclusions: Our systematic review of trials on high-risk MDs confirms previous research, which has documented deficiencies regarding data availability and a lack of reporting on sample size calculation. More effort is needed to ensure both relevant sources, that is, original research protocols, to be publicly available and reporting requirements to be standardized.

Objectives: The suitability of general HTA methodology for medical devices is gaining interest as a topic of scientific discourse. Given the broad range of medical devices, there might be differences between groups of devices that impact both the necessity and the methods of their assessment. Our aim is to develop a taxonomy that provides researchers and policy makers with an orientation tool on how to approach the assessment of different types of medical devices.

Methods: Several classifications for medical devices based on varying rationales for different regulatory and reporting purposes were analyzed in detail to develop a comprehensive taxonomic model.

Results: The taxonomy is based on relevant aspects of existing classification schemes incorporating elements of risk and functionality. Its 9 × 6 matrix distinguishes between the diagnostic or therapeutic nature of devices and considers whether the medical device is directly used by patients, constitutes part of a specific procedure, or can be used for a variety of procedures. We considered the relevance of different device categories in regard to HTA to be considerably variable, ranging from high to low.

Conclusions: Existing medical device classifications cannot be used for HTA as they are based on different underlying logics. The developed taxonomy combines different device classification schemes used for different purposes. It aims at providing decision makers with a tool enabling them to consider device characteristics in detail across more than one dimension. The placement of device groups in the matrix can provide decision support on the necessity of conducting a full HTA.

The German Antarctic Receiving Station (GARS) O’Higgins at the northern tip of the Antarctic Peninsula is a dual purpose facility for earth observation and has existed for more than 20 years. It serves as a satellite ground station for payload data downlink and telecommanding of remote sensing satellites as well as a geodetic observatory for global reference systems and global change. Both applications use the same 9 m diameter radio antenna. Major outcomes of this usage are summarised in this paper.

The satellite ground station O’Higgins (OHG) is part of the global ground station network of the German Remote Sensing Data Centre (DFD) operated by the German Aerospace Centre (DLR). It was established in 1991 to provide remote sensing data downlink support within the missions of the European Remote Sensing Satellites ERS-1 and ERS-2. These missions provided valuable insights into the changes of the Antarctic ice shield. Especially after the failure of the on-board data recorder, OHG became an essential downlink station for ERS-2 real-time data transmission. Since 2010, OHG is manned during the entire year, specifically to support the TanDEM-X mission. OHG is a main dump station for payload data, monitoring and telecommanding of the German TerraSAR-X and TanDEM-X satellites.

For space geodesy and astrometry the radio antenna O’Higgins significantly improves coverage over the southern hemisphere and plays an essential role within the global Very Long Baseline Interferometry (VLBI) network. In particular the determination of the Earth Orientation Parameters (EOP) and the sky coverage of the International Celestial Reference Frame (ICRF) benefit from the location at a high southern latitude. Further, the resolution of VLBI images of active galactic nuclei (AGN), cosmic radio sources defining the ICRF, improves significantly when O’Higgins is included in the network. The various geodetic instrumentation and the long time series at O’Higgins allow a reliable determination of crustal motions. VLBI station velocities, continuous GNSS measurements and campaign-wise absolute gravity measurements consistently document a vertical rate of about 5 mm/a. This crustal uplift is interpreted as an elastic rebound due to ice loss as a consequence of the ice shelf disintegration in the Prince Gustav Channel in the late 1990s.

The outstanding location on the Antarctic continent and its year-around operation make GARS O’Higgins in future increasingly attractive for polar orbiting satellite missions and a vitally important station for the global VLBI network. Future plans call for the development of an observatory for environmentally relevant research. That means that the portfolio of the station will be expanded including the expansion of the infrastructure and the construction and operation of new scientific instruments suitable for long-term measurements and satellite ground truthing.