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159 results

Page 1 of 8

  • Kounis syndrome following allergy injection in a paediatric patient
  • Maria Mason, Matthew D. Campbell
  • Journal: Cardiology in the Young , First View
  • Published online by Cambridge University Press: 26 July 2022, pp. 1-3
  • View abstract

    Kounis syndrome is the concurrence of acute coronary syndrome or coronary vasospasm with conditions associated with the release of inflammatory cytokines through mast cell activation in the setting of allergic or anaphylactic reactions. Many identified triggers have been identified in paediatric patients including exposures, drugs, and immunisations; however, to our knowledge this is the first case report of Kounis syndrome linked to immunotherapy. We present a case of a 9-year-old with seasonal allergies presenting with clinical symptoms of Kounis syndrome following her weekly subcutaneous injection of allergens. Clinicians need a high index of suspicion for Kounis syndrome in patients who develop systemic signs of anaphylaxis with clinical, laboratory, electrocardiographic, and echocardiographic findings of acute coronary syndrome to help direct therapy and improve outcomes.

  • Chapter 8 - The Eclipse of Dora Sigerson
  • Edited by Ailbhe Darcy, Cardiff University, David Wheatley, University of Aberdeen
  • Book: A History of Irish Women's Poetry
  • Published online: 11 June 2021
  • Print publication: 01 July 2021, pp 158-172
  • View extract

    Summary

    The career of Dora Sigerson (1866–1918), also known as Dora Sigerson Shorter, moves between the worlds of the nineteenth-century nationalist ballad and the Edwardian lyric. Born a year after W. B. Yeats, she established herself on the British literary scene, becoming a friend of Thomas Hardy and reviewed in the Times Literary Supplement by Virginia Woolf, but experienced the Easter Rising as a traumatic call to reconnect with Ireland. A vein of agnostic anxiety runs through her work, which engages with themes of depression, ghostly visitations, and suicide. The poems of her final period move between private and public dramas, aspiring to a monumental framework (Sigerson was also a sculptor) but exploring Anglo-Irish relations through the familiar prism of a strained marriage. Her final work tackles wider themes of imperial wrongs, including slavery, while teetering on the edge of breakdown. Moving as she does between contrasting modes, Sigerson is a poet who has arguably still to find her audience, but whose work has much to tell us about how Irish poetry has been read and received over the last century.

  • Chapter 5 - Wordsworth and Romanticism
  • from II - Influences and Traditions
  • Edited by Geraldine Higgins, Emory University, Atlanta
  • Book: Seamus Heaney in Context
  • Published online: 15 March 2021
  • Print publication: 01 April 2021, pp 61-72
  • View extract

    Summary

    Seamus Heaney’s poetry and criticism kept up a regular conversation with Romantic and post-Romantic poetics: from Wordsworth to Hopkins, Frost, Plath and more. He initially found in Frost’s relation to the natural, ‘a primal reach into the physical’. This he developed into a poetic which balanced the need for roots in an account of the formation of the poet’s self, and the need for an individual voice which found responsibility in ‘an unconceding pursuit of poetic insight and poetic knowledge’. The route was via watery places, and an approach to the autobiographical grounded in Wordsworth, which was figured through the making and unmaking of gender. If Heaney’s later poetry was to trade this rootedness in for a sort of transcendence – ‘walking on air’ – he still remained preoccupied with its forging in imitation, its duty to communicate, and its desire for its own autonomy.

  • Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts
  • Alex S. F. Kwong, Rebecca M. Pearson, Mark J. Adams, Kate Northstone, Kate Tilling, Daniel Smith, Chloe Fawns-Ritchie, Helen Bould, Naomi Warne, Stanley Zammit, David J. Gunnell, Paul A. Moran, Nadia Micali, Abraham Reichenberg, Matthew Hickman, Dheeraj Rai, Simon Haworth, Archie Campbell, Drew Altschul, Robin Flaig, Andrew M. McIntosh, Deborah A. Lawlor, David Porteous, Nicholas J. Timpson
  • Journal: The British Journal of Psychiatry / Volume 218 / Issue 6 / June 2021
  • Published online by Cambridge University Press: 24 November 2020, pp. 334-343
  • Print publication: June 2021
    • Article
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  • View abstract
    Background

    The COVID-19 pandemic and mitigation measures are likely to have a marked effect on mental health. It is important to use longitudinal data to improve inferences.

    Aims

    To quantify the prevalence of depression, anxiety and mental well-being before and during the COVID-19 pandemic. Also, to identify groups at risk of depression and/or anxiety during the pandemic.

    Method

    Data were from the Avon Longitudinal Study of Parents and Children (ALSPAC) index generation (n = 2850, mean age 28 years) and parent generation (n = 3720, mean age 59 years), and Generation Scotland (n = 4233, mean age 59 years). Depression was measured with the Short Mood and Feelings Questionnaire in ALSPAC and the Patient Health Questionnaire-9 in Generation Scotland. Anxiety and mental well-being were measured with the Generalised Anxiety Disorder Assessment-7 and the Short Warwick Edinburgh Mental Wellbeing Scale.

    Results

    Depression during the pandemic was similar to pre-pandemic levels in the ALSPAC index generation, but those experiencing anxiety had almost doubled, at 24% (95% CI 23–26%) compared with a pre-pandemic level of 13% (95% CI 12–14%). In both studies, anxiety and depression during the pandemic was greater in younger members, women, those with pre-existing mental/physical health conditions and individuals in socioeconomic adversity, even when controlling for pre-pandemic anxiety and depression.

    Conclusions

    These results provide evidence for increased anxiety in young people that is coincident with the pandemic. Specific groups are at elevated risk of depression and anxiety during the COVID-19 pandemic. This is important for planning current mental health provisions and for long-term impact beyond this pandemic.

  • Depressed mood and anxiety as risk factors for hypertensive disorders of pregnancy: a systematic review and meta-analysis
  • Matthew Shay, Anna L. MacKinnon, Amy Metcalfe, Gerald Giesbrecht, Tavis Campbell, Kara Nerenberg, Suzanne Tough, Lianne Tomfohr-Madsen
  • Journal: Psychological Medicine / Volume 50 / Issue 13 / October 2020
  • Published online by Cambridge University Press: 11 September 2020, pp. 2128-2140
  • Print publication: October 2020
  • View abstract
    Background

    Psychosocial factors have been implicated as both a cause and consequence of hypertension in the general population but are less understood in relation to hypertensive disorders of pregnancy (HDP). The aims of this review were to (1) synthesize the existing literature examining associations between depression and/or anxiety in pregnancy and HDP and (2) assess if depression and/or anxiety in early pregnancy was a risk factor for HDP.

    Methods

    A comprehensive search of Medline, Embase, CINAHL, and PsycINFO was conducted from inception to March 2020 using terms related to ‘pregnancy’, ‘anxiety’, ‘depression’, and ‘hypertensive disorders’. English-language cohort and case-control studies were included if they reported: (a) the presence or absence of clinically significant symptoms of depression/anxiety, or a medical record diagnosis of depression or an anxiety disorder in pregnancy; (b) diagnosis of HDP; and/or (c) data comparing the depressed/anxious group to the non-depressed/anxious group on HDP. Data related to depression/anxiety, HDP, study characteristics, and aspects related to study quality were extracted independently by two reviewers. Random-effects meta-analyses of estimated pooled relative risks (RRs) were conducted for depression/anxiety in pregnancy and HDP.

    Results

    In total, 6291 citations were retrieved, and 44 studies were included across 61.2 million pregnancies. Depression and/or anxiety were associated with HDP [RR = 1.39; 95% confidence interval (CI) 1.25–1.54].

    Conclusions

    When measurement of anxiety or depression preceded diagnosis of hypertension, the association remained (RR = 1.27; 95% CI 1.07–1.50). Women experiencing depression or anxiety in pregnancy have an increased prevalence of HDP compared to their non-depressed or non-anxious counterparts.

  • Imagery-enhanced v. verbally-based group cognitive behavior therapy for social anxiety disorder: a randomized clinical trial
  • Peter M. McEvoy, Matthew P. Hyett, Samantha R. Bank, David M. Erceg-Hurn, Andrew R. Johnson, Michael J. Kyron, Lisa M. Saulsman, Michelle L. Moulds, Jessica R. Grisham, Emily A. Holmes, David A. Moscovitch, Ottmar V. Lipp, Bruce N. C. Campbell, Ronald M. Rapee
  • Journal: Psychological Medicine / Volume 52 / Issue 7 / May 2022
  • Published online by Cambridge University Press: 11 September 2020, pp. 1277-1286
  • Print publication: May 2022
  • View abstract
    Background

    Cognitive behavior therapy (CBT) is effective for most patients with a social anxiety disorder (SAD) but a substantial proportion fails to remit. Experimental and clinical research suggests that enhancing CBT using imagery-based techniques could improve outcomes. It was hypothesized that imagery-enhanced CBT (IE-CBT) would be superior to verbally-based CBT (VB-CBT) on pre-registered outcomes.

    Methods

    A randomized controlled trial of IE-CBT v. VB-CBT for social anxiety was completed in a community mental health clinic setting. Participants were randomized to IE (n = 53) or VB (n = 54) CBT, with 1-month (primary end point) and 6-month follow-up assessments. Participants completed 12, 2-hour, weekly sessions of IE-CBT or VB-CBT plus 1-month follow-up.

    Results

    Intention to treat analyses showed very large within-treatment effect sizes on the social interaction anxiety at all time points (ds = 2.09–2.62), with no between-treatment differences on this outcome or clinician-rated severity [1-month OR = 1.45 (0.45, 4.62), p = 0.53; 6-month OR = 1.31 (0.42, 4.08), p = 0.65], SAD remission (1-month: IE = 61.04%, VB = 55.09%, p = 0.59); 6-month: IE = 58.73%, VB = 61.89%, p = 0.77), or secondary outcomes. Three adverse events were noted (substance abuse, n = 1 in IE-CBT; temporary increase in suicide risk, n = 1 in each condition, with one being withdrawn at 1-month follow-up).

    Conclusions

    Group IE-CBT and VB-CBT were safe and there were no significant differences in outcomes. Both treatments were associated with very large within-group effect sizes and the majority of patients remitted following treatment.

  • Chapter 1 - Victorian Ireland, 1830–1880: A Transition State
  • from Part I - Contexts and Contents: Politics and Periodicals
  • Edited by Matthew Campbell, University of York
  • Book: Irish Literature in Transition, 1830–1880
  • Published online: 29 February 2020
  • Print publication: 12 March 2020, pp 3-21
  • View extract

    Summary

    It is a point of some controversy whether we can call the Ireland of the nineteenth-century ‘Victorian’, for all that Victoria was its head of state within the United Kingdom. While not a state in itself, Ireland was certainly going through what William Carleton called in 1842 a ‘transition state’. There is much that is preliminary, provisional or even experimental about the writing of nineteenth-century Ireland, caught between Romanticism and Revival and never fully accounted for in the mainstream of Victorian literary history. The writing, too, was not located solely in Ireland: famine and mass emigration meant that the Irish found themselves in the United States, Australia or India, both as participants in decolonising movements or as servants of Empire. This chapter surveys the twin location of Irish literature, nationalist and diasporic. It focuses on the work of Carleton and Jane Elgee (Speranza) while also introducing many of the themes and authors which are the subject matter of the pages that follow.

  • Chapter 4 - Whigs, Weavers, and Fire-Worshippers: Anglophone Irish Poetry in Transition
  • from Part II - Transitions
  • Edited by Claire Connolly, University College Cork
  • Book: Irish Literature in Transition, 1780–1830
  • Published online: 28 February 2020
  • Print publication: 12 March 2020, pp 85-106
  • View extract

    Summary

    The Irish poetry of the romantic age is dominated by its best-known figure, Thomas Moore. While Moore claimed that his songs were responsible for saving the national literary and musical culture, there were, of course, many other writers producing poetry in differing modes, languages, and registers. This chapter begins and ends with Moore’s considerable achievements, but it also deals with three issues that preoccupied Irish poetic and cultural debate in the period and after: translation, authenticity, and quality. The debate gains its first focus in the work of Charlotte Brooke, but continues through Moore’s contact with music in the collections of Edward Bunting. This period was also one of considerable historical moment, and the chapter also addresses poetry written out of the contact with French revolutionary ideas, the United Irishmen, 1798, and Union. Among poets considered are also William Drennan, Mary Tighe, James Orr, and Thomas Dermody, writing in English and Ulster Scots as well as in contact with the Irish-language tradition, mock-epic, and the oriental.

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