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Placental remnants following birth are often heralded by secondary post-partum haemorrhage. Diagnosis is assisted by an ultrasound scan, with MRI indicated when the scan is inconclusive. Emergency measures are required for excessive bleeding. A conservative approach is appropriate when bleeding is not heavy. Confirmation of intra-uterine placental tissue by repeated scans ensures surgery is confined to women with a high chance of retained tissue. Traditional curettage is often replaced by hysteroscopic resection allowing direct and precise removal of placental remnants with less trauma to adjacent normal endometrium. Hysteroscopic treatment, under general anaesthetic or as an outpatient, is preferably deferred for 2–3 months after delivery to minimise complications, without compromising longer-term outcomes like fertility or subsequent pregnancy rates. Intra-uterine adhesions may occur especially following repeated blind curettage, which can compromise future fertility. Clear communication with the patient and partner is important. Further research into the management options for postdelivery placental remnants is required to ascertain best practice.
It is important for SARS-CoV-2 vaccine providers, vaccine recipients, and those not yet vaccinated to be well informed about vaccine side effects. We sought to estimate the risk of post-vaccination venous thromboembolism (VTE) to meet this need.
Methods
We conducted a retrospective cohort study to quantify excess VTE risk associated with SARS-CoV-2 vaccination in US veterans age 45 and older using data from the Department of Veterans Affairs (VA) National Surveillance Tool. The vaccinated cohort received at least one dose of a SARS-CoV-2 vaccine at least 60 days prior to 3/06/22 (N = 855,686). The control group was those not vaccinated (N = 321,676). All patients were COVID-19 tested at least once before vaccination with a negative test. The main outcome was VTE documented by ICD10-CM codes.
Results
Vaccinated persons had a VTE rate of 1.3755 (CI: 1.3752–1.3758) per thousand, which was 0.1 percent over the baseline rate of 1.3741 (CI: 1.3738–1.3744) per thousand in the unvaccinated patients, or 1.4 excess cases per 1,000,000. All vaccine types showed a minimal increased rate of VTE (rate of VTE per 1000 was 1.3761 (CI: 1.3754–1.3768) for Janssen; 1.3757 (CI: 1.3754–1.3761) for Pfizer, and for Moderna, the rate was 1.3757 (CI: 1.3748–1.3877)). The tiny differences in rates comparing either Janssen or Pfizer vaccine to Moderna were statistically significant (p < 0.001). Adjusting for age, sex, BMI, 2-year Elixhauser score, and race, the vaccinated group had a minimally higher relative risk of VTE as compared to controls (1.0009927 CI: 1.007673–1.0012181; p < 0.001).
Conclusion
The results provide reassurance that there is only a trivial increased risk of VTE with the current US SARS-CoV-2 vaccines used in veterans older than age 45. This risk is significantly less than VTE risk among hospitalized COVID-19 patients. The risk-benefit ratio favors vaccination, given the VTE rate, mortality, and morbidity associated with COVID-19 infection.
Childhood maltreatment can result in lifelong psychological and physical sequelae, including coronary artery disease (CAD). Mechanisms leading to increased risk of illness may involve emotional dysregulation and shortened leukocyte telomere length (LTL).
Methods
To evaluate whether (1) childhood maltreatment is associated with shorter LTL among older adults with CAD or other chronic illnesses; (2) sex and/or CAD status influence these results; and (3) symptoms of anxiety, depression, and stress moderate or mediate the association between childhood maltreatment and LTL, men and women (N = 1247; aged 65 ± 7.2 years) with and without CAD completed validated questionnaires on childhood maltreatment, symptoms of depression, anxiety, and perceived stress. LTL was measured using quantitative polymerase chain reaction. Analyses included bivariate correlations, hierarchical regressions, and moderation/mediation analyses, controlling for sociodemographic and lifestyle variables.
Results
Childhood maltreatment was associated with significantly shorter LTL (r = −0.059, p = 0.038, b = −0.016, p = 0.005). This relation was not moderated by depression, anxiety, nor perceived stress, though there was mitigated evidence for absence of a maltreatment-LTL relation in men with CAD. Stress perception (but not anxiety or depression) partially mediated the relation between childhood maltreatment and LTL [Indirect effect, b = −0.0041, s.e. = 0.002, 95% CI (−0.0085 to −0.0002)].
Conclusions
Childhood maltreatment was associated with accelerated biological aging independently of patient characteristics. Emotional dysregulation resulting in chronic stress may contribute to this process. Whether stress management or other interventions may help prevent or slow premature aging in those who have suffered maltreatment requires study.
Parents of children with eczema or psoriasis experience high levels of parenting stress, which can negatively impact their child’s mental and physical health.
Aims:
We aimed to investigate the effectiveness, feasibility and acceptability of a mindful parenting intervention for parents of children with eczema or psoriasis.
Method:
Seven parents of children (4–12 years old) with eczema or psoriasis took part in an 8-week mindful parenting group intervention. A single-case experimental design was adopted, whereby parents completed daily idiographic measures of parenting stress related to their child’s skin condition. Parents also completed standardised questionnaires measuring their parenting stress, depression, anxiety and quality of life, and children completed a quality of life measure, at four time points: baseline, pre-intervention, post-intervention and 6-week follow-up. Parents provided qualitative feedback after the intervention.
Results:
All parents completed the intervention and showed improvements in idiographic measures of parenting stress from baseline to follow-up. Improvements in parenting stress were larger at follow-up than post-intervention, suggesting the benefits of intervention continue beyond the intervention. Six of seven parent–child dyads showed improvement in at least one of the wellbeing measures, from pre-intervention to post-intervention or follow-up. Feasibility was demonstrated through good participant retention, adherence to home practice, and treatment fidelity. Acceptability was demonstrated through positive parent evaluations of the intervention.
Conclusions:
Mindful parenting can be an effective, feasible and acceptable intervention for parents of children with eczema or psoriasis. Future studies should attempt to replicate the findings through randomised controlled trials.
Uterine fibroids are common. They arise from the myometrium and occur in approximately 20–25% of women aged 35 years or more [1]. They may be found at any position within the myometrium from the serosal surface to lying completely within the uterine cavity in 5–10% [2].
There is limited data describing the characteristics of paediatric post-operative cardiac surgery patients who develop pneumothoraces after chest tube removal. Patient management after chest tube removal is not standardised across paediatric cardiac surgery programmes. The purposes of this study were to describe the frequency of pneumothorax after chest tube removal in paediatric post-operative cardiac surgical patients and to describe the patient and clinical characteristics of those patients who developed a clinically significant pneumothorax requiring intervention.
Methods:
A single-institution retrospective descriptive study (1 January, 2010–31 December, 2018) was utilised to review 11,651 paediatric post-operative cardiac surgical patients from newborn to 18 years old.
Results:
Twenty-five patients were diagnosed with a pneumothorax by chest radiograph following chest tube removal (0.2%). Of these 25 patients, 15 (1.6%) had a clinically significant pneumothorax and 8 (53%) did not demonstrate a change in baseline clinical status or require an increase in supplemental oxygen, 14 (93%) required an intervention, 9 (60%) were <1 year of age, 4 (27%) had single-ventricle physiology, and 5 (33%) had other non-cardiac anomalies/genetic syndromes.
Conclusions:
In our cohort of patients, we confirmed the incidence of pneumothorax after chest tube removal is low in paediatric post-operative cardiac surgery patients. This population does not always exhibit changes in clinical status despite having clinically significant pneumothoraces. We suggest the development of criteria, based on clinical characteristics, for patients who are at increased risk of developing a pneumothorax and would require a routine chest radiograph following chest tube removal.
This expert guide will help readers learn about the role of hysteroscopy in the management of a range of common and less common gynaecological problems. In particular, the book covers the diagnosis and treatment of endometrial and uterine anatomical abnormalities that are associated with abnormal uterine bleeding and impairment of reproduction. Contemporary hysteroscopic techniques are described allowing the reader to understand how to perform both inpatient and outpatient procedures. Based on the annual RCOG/BSGE Diagnostic and Operative Hysteroscopy training course, this comprehensive guide covers fundamental topics such as equipment, energy modalities and operative set up. The book also explores innovative ambulatory surgery and hysteroscopic interventions in an operating theatre environment. Written by international experts in hysteroscopy and including sections on training in, and monitoring of clinical practice, this guide proves an ideal companion for health care professionals looking to provide best clinical practice and optimal patient experience.
Over the ages, clinicians have tried to decipher the mysteries of the human body by exploiting natural openings to examine the internal aspects of organs. Since as far back as Hippocrates, a variety of instruments have been employed to achieve this. The simplest form of instrument is a speculum, used to augment natural openings and allow ambient light to illuminate the inner aspect of organs for inspection by the naked eye. While this may be helpful for examining the nostrils or the vagina, for example, it is not an adequate approach for a well-concealed organ such as the uterus. Accurate endoscopic examination of the endometrial cavity, i.e. hysteroscopy, requires the transmission of light into and out of a cavity. Since the endometrial cavity is a potential space, collapsed in the natural state, a distension medium is required to expand the field of vision.
Endometrial ablation (EA) is a minimally invasive surgical intervention that aims to reduce heavy menstrual bleeding (HMB) by destroying functionally active endometrial glands within the endometrium and the superficial myometrium, including the deep basal glands. To prevent regeneration and stop menstruation this destruction should be to a depth of 5 mm. In the past, destruction of the endometrium required an operating hysteroscope. Endometrial tissue was either removed using an electrical cutting loop or destroyed by applying thermal energy to induce necrosis using an electrical ‘rollerball’ or laser fibre. These first-generation techniques have largely been superseded by second-generation techniques that comprise semi-automated global ablative systems using a variety of energy sources to thermally ablate the endometrium. These systems require less operator skill, are less likely to require general anaesthesia, are quicker to perform and offer enhanced safety with no loss in effectiveness.
The first part of this chapter has been written with the patient’s journey in mind: from the time of presentation to the general practitioner (GP) with a problem such as abnormal uterine bleeding, through referral to secondary care for investigation, including hysteroscopy if appropriate, and to treatment as indicated. We hope this approach will clarify what is involved in providing such a service. In the second half of the chapter, the equipment required for providing hysteroscopy services is described in detail, making extensive use of published standards and guidelines for gynaecology and hysteroscopy specifically.
Hysteroscopy involves both diagnostic and therapeutic procedures. Inpatient hysteroscopy is well established, but the development of outpatient services is relatively new. Audit is the process by which we assess a service against recognised standards; data collection enables us to perform an audit; clinical governance provides the framework for safe and effective patient care.
Surgical procedures using electrosurgery can be undertaken within the uterine cavity to address excessive menstrual blood loss and to enhance fertility. The insertion of specialised electrodes down hysteroscopic instruments enables the direct application of electricity to uterine tissue. The electrical energy is transformed into heat and, depending upon how this heat is focused, can be used to cut tissue and excise lesions, or cauterise and ablate tissue (Box 8.1). The larger hysteroscopic resectoscopes with outer diameters of 7 to 8.5 mm are generally, though not exclusively, used during inpatient procedures with a general anaesthetic or regional anaesthesia. The introduction of smaller electrodes (1.67 mm, or 5 Fr) has enabled therapeutic procedures to be undertaken using diagnostic hysteroscopes with an operating channel. This has supported the development of outpatient operative hysteroscopy for the removal of small intrauterine lesions.
Training allows healthcare professionals to develop skills that benefit patients, improve their care and keep them safe. It is an essential aspect of reducing or preventing harm to our patients.
Over the past two decades there has been a significant shift in surgical education away from an apprenticeship model that had existed for centuries towards the use of clinical skills and simulation training. This can be undertaken in a safe environment, allowing healthcare professionals to begin their learning and practice of skills away from patients. Proponents of the ‘new’ system point to the increased availability of simulation equipment, both low (sometimes called basic) and high fidelity (virtual reality high technology systems), in NHS hospitals and university departments throughout the UK. In addition, there is a wealth of evidence supporting simulation as an important educational tool in medicine that has the potential to significantly reduce the chances of harm to patients.
Improved hysteroscopic technology has enabled clinicians not only to perform diagnostic outpatient hysteroscopy but also to treat uterine lesions. Bipolar diathermy electrodes have reduced the risk of fluid overload, allowing the excision of larger fibroids at a single setting and thus reducing the need for abdominal operations. Novel indications for hysteroscopy have become available, such as hysteroscopic tubal occlusion. Concomitant developments in hysteroscopic equipment and ultrasound technology have influenced how these tools are used in the diagnosis and treatment of intrauterine conditions.
The uterus is the primary female reproductive organ. It is situated within the pelvis and measures approximately 8 cm in length, 4 cm in width and 5 cm in depth in the normal, non-pregnant state. Though relatively quiescent in pre-pubertal and post-menopausal years, the uterus possesses a variety of functions during a woman’s reproductive years. It responds to the production of female hormones, creating changes to allow for implantation of a fertilised egg, or menstruation when pregnancy does not occur. It is also able to rapidly expand with the development of a pregnancy and has a contractile function for labour and delivery during childbirth [1].