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Grain-cooking traditions in Neolithic China have been characterised as a ‘wet’ cuisine based on the boiling and steaming of sticky varieties of cereal. One of these, broomcorn millet, was one of the earliest Chinese crops to move westward into Central Asia and beyond, into regions where grains were typically prepared by grinding and baking. Here, the authors present the genotypes and reconstructed phenotypes of 13 desiccated broomcorn millet samples from Xinjiang (1700 BC–AD 700). The absence in this area of sticky-starch millet and vessels for boiling and steaming suggests that, as they moved west, East Asian cereal crops were decoupled from traditional cooking practices and were incorporated into local cuisines.
To assess the impact of the coronavirus disease 2019 (COVID-19) pandemic on healthcare-associated infections (HAIs) reported from 128 acute-care and 132 long-term care Veterans Affairs (VA) facilities.
Methods:
We compared central-line–associated bloodstream infections (CLABSIs), ventilator-associated events (VAEs), catheter-associated urinary tract infections (CAUTIs), methicillin-resistant Staphylococcus aureus (MRSA), and Clostridioides difficile infections and rates reported from each facility monthly to a centralized database before the pandemic (February 2019 through January 2020) and during the pandemic (July 2020 through June 2021).
Results:
Nationwide VA COVID-19 admissions peaked in January 2021. Significant increases in the rates of CLABSIs, VAEs, and MRSA all-site HAIs (but not MRSA CLABSIs) were observed during the pandemic in acute-care facilities. There was no significant change in CAUTI rates, and C. difficile rates significantly decreased. There were no significant increases in HAIs in long-term care facilities.
Conclusions:
The COVID-19 pandemic had a differential impact on HAIs of various types in VA acute care, with many rates increasing. The decrease in CDI HAIs may be due, in part, to evolving diagnostic testing. The minimal impact of COVID-19 in VA long-term facilities may reflect differences in patient numbers and acuity and early recognition of the impact of the pandemic on nursing home residents leading to increased vigilance and optimization of infection prevention and control practices in that setting. These data support the need for building and sustaining conventional infection prevention and control strategies before and during a pandemic.
The Variables and Slow Transients Survey (VAST) on the Australian Square Kilometre Array Pathfinder (ASKAP) is designed to detect highly variable and transient radio sources on timescales from 5 s to
$\sim\!5$
yr. In this paper, we present the survey description, observation strategy and initial results from the VAST Phase I Pilot Survey. This pilot survey consists of
$\sim\!162$
h of observations conducted at a central frequency of 888 MHz between 2019 August and 2020 August, with a typical rms sensitivity of
$0.24\ \mathrm{mJy\ beam}^{-1}$
and angular resolution of
$12-20$
arcseconds. There are 113 fields, each of which was observed for 12 min integration time, with between 5 and 13 repeats, with cadences between 1 day and 8 months. The total area of the pilot survey footprint is 5 131 square degrees, covering six distinct regions of the sky. An initial search of two of these regions, totalling 1 646 square degrees, revealed 28 highly variable and/or transient sources. Seven of these are known pulsars, including the millisecond pulsar J2039–5617. Another seven are stars, four of which have no previously reported radio detection (SCR J0533–4257, LEHPM 2-783, UCAC3 89–412162 and 2MASS J22414436–6119311). Of the remaining 14 sources, two are active galactic nuclei, six are associated with galaxies and the other six have no multi-wavelength counterparts and are yet to be identified.
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
Aims
To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
Method
Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
Results
Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
Conclusions
AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
Scholarly interest has been growing in an episode of Old World globalisation of food resources significantly predating the ‘Silk Road’. This process was characteristic of crosscontinental translocations of starch-based crops mostly during the third and second millennia BC but which might have been initiated in an earlier period (Jones et al. 2011). Among these translocations we can include a range of crops originally from Southwest Asia, notably bread wheat and barley, and others originally from northern China, such as broomcorn and foxtail millet (Hunt et al. 2008; Motuzaite-Matuzeviciute et al. 2013). Parallel patterns of crop movement between North Africa and South Asia have been observed and discussed in some depth (Boivin & Fuller 2009; Fuller et al. 2011; Boivin et al. 2013). The impetus behind this growth of interest has been the expansion of archaeobotanical research in South and East Asia over the past decade (Fuller 2002; Crawford 2006; Lee et al. 2007; Liu et al. 2008; Zhao 2010). This paper considers the agents responsible for the food globalisation process during the third and second millennia BC. A key aspect of trans-Eurasian starch-crop movement was that it constituted an addition to agricultural systems, rather than movement to regions devoid of existing starch-based agriculture. Other economic plants, such as grapes, dates and peas, also moved considerable distances in the archaeological record, often to areas previously devoid of those plants. However, the novel starchy crops held a particular significance. In both cases, Southwest Asian wheat and barley and East Asian millets went on to become important staple foods in many of their new destinations.
The classic image of Upper Palaeolithic hunter-gatherers in Europe envisages them hunting large mammals in largely treeless landscapes. That is partly due to the nature of the surviving archaeological evidence, and the poor preservation of plant remains at such ancient sites. As this study illustrates, however, the potential of Upper Palaeolithic sites to yield macrofossil remains of plants gathered and processed by human groups has been underestimated. Large scale flotation of charred deposits from hearths such as that reported here at Dolní Vӗstonice II not only provides insight into the variety of flora that may have been locally available, but also suggests that some of it was being processed and consumed as food. The ability to exploit plant foods may have been a vital component in the successful colonisation of these cold European habitats.
The majority of the early crops grown in Europe had their origins in south-west Asia, and were part of a package of domestic plants and animals that were introduced by the first farmers. Broomcorn millet, however, offers a very different narrative, being domesticated first in China, but present in Eastern Europe apparently as early as the sixth millennium BC. Might this be evidence of long-distance contact between east and west, long before there is any other evidence for such connections? Or is the existing chronology faulty in some way? To resolve that question, 10 grains of broomcorn millet were directly dated by AMS, taking advantage of the increasing ability to date smaller and smaller samples. These showed that the millet grains were significantly younger than the contexts in which they had been found, and that the hypothesis of an early transmission of the crop from east to west could not be sustained. The importance of direct dating of crop remains such as these is underlined.
Francesco Guala has developed some novel and radical ideas on the problem of external validity, a topic that has not received much attention in the experimental economics literature. In this paper I argue that his views on external validity are not justified and the conclusions which he draws from these views, if widely adopted, could substantially undermine the experimental economics enterprise. In rejecting the justification of these views, the paper reaffirms the importance of experiments in economics.