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X-ray and Sunyaev–Zeldovich effect (SZE) observations of galaxy clusters can be used to measure their distances independently of the cosmic distance ladder. We have determined the distance to 38 clusters of galaxies in the redshift range 0.14 ≤ z ≤ 0.89 using X-ray data from the Chandra X-ray Observatory and SZE data from the Owens Valley Radio Observatory and the Berkeley–Illinois–Maryland Association interferometric arrays. We measure a Hubble constant of H0 = 76.9+3.9−3.4+10.0−8.0 km s−1 Mpc−1 (statistical followed by systematic uncertainties at 68% confidence) for an ΩM=0.3, ΩΛ=0.7 cosmology. Our determination of the Hubble parameter in the distant Universe agrees with measurements from the Hubble Space Telescope Key Project that probed the nearby Universe.
A recent review suggested an association between using unpublished scales in clinical trials and finding significant results.
Aims
To determine whether such an association existed in schizophrenia trials.
Method
Three hundred trials were randomly selected from the Cochrane Schizophrenia Group's Register. All comparisons between treatment groups and control groups using rating scales were identified. The publication status of each scale was determined and claims of a significant treatment effect were recorded.
Results
Trials were more likely to report that a treatment was superior to control when an unpublished scale was used to make the comparison (relative risk 1.37 (95% C11.12–1.68)). This effect increased when a ‘gold-standard’ definition of treatment superiority was applied (RR 1.94 (95% C11.35–2.79)). In non-pharmacological trials, one-third of ‘gold-standard’ claims of treatment superiority would not have been made if published scales had been used.
Conclusions
Unpublished scales are a source of bias in schizophrenia trials.
New mapping and analysis techniques for NASA's Kuiper Airborne Observatory are described which permit us to obtain information of size scales of order 10″ in the far-infrared. Basically, the focal-plane image is highly oversampled while the telescope is scanned smoothly and repeatedly over the region of interest with a slit of size λ/D. Maximum-entropy deconvolution is then used to obtain spectral frequency information down to scales of ∼ λ/2D.
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