This article explores the past, present, and possible future directions of the ‘‘new thalassology’’ [from the ancient Greek thalassa, ‘‘sea’’] and Indian Ocean studies from its humble beginnings in the 1950s and 1960s, and the cross-fertilization between the ‘Annales’ school and world-systems analysis in the 1980s, to its – admittedly incomplete – institutionalization in the early twenty-first century. In addition, it defines the numerous, often flexible and permeable, spatial and temporal boundaries or ‘frontiers’ of the Indian Ocean world(s). A final section surveys some of the potentialities and pitfalls of Indian Ocean studies and the new thalassology, with the strengths outweighing the weaknesses. The new thalassology undoubtedly presents some daunting challenges. It is to be hoped, however, that charting some of the ‘hundred frontiers’ of the globalized, inter-regional Indian Ocean seascape provides some sense of direction for this exciting field of scholarship and helps shape the future contours of maritime-based studies