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A 32-year-old right-handed woman developed persistent fever with malaise and nausea. The symptoms persisted for 2 weeks, after which she was admitted because of delirium, amnesia, and repetitive generalized convulsions with loss of consciousness. She had no remarkable past and family medical history, which included a history of abortions and thyroiditis. However, she had gained a body weight of 20 kg in the 1 year preceding this episode. She was not on medication and did not smoke or consume alcohol.
Temperature is one of the most influential factors for the sexual maturation of fishes, but understanding of the extent to which temperature affects the maturational schedules is limited in multiple-spawning fishes over a protracted season. This study examined the effect of temperature on sexual maturation of Japanese anchovy Engraulis japonicus siblings under high and low temperature regimes on different birthdates. The maturation probability differed between the two temperature regimes. Specimens in high temperature regimes matured at much smaller size and younger age than their counterparts. Also, a significant difference in the maturation probability between sexes was found at low temperatures, but not at high temperatures. Our findings show that temperature affects the maturational schedules of siblings of Japanese anchovy, suggesting that the size and age at sexual maturation could differ among cohorts, even in a given sampling location and/or year.
This chapter speaks about an 82-year-old woman who was admitted with apparently sudden-onset neurological symptoms. On examination, this patient appeared well and comfortable. The patient's clinical evolution was characterized by a relentlessly progressive course over several weeks. The visual field defect expanded into a right homonymous hemianopia, and optic ataxia also developed on the left. Dysarthria and dysphagia worsened until she was dependent on tube feeding. The human prion diseases are a comparatively rare cause of dementia, with an estimated incidence of 1 case per million people per year, although some uncorroborated reports would place the true incidence much higher. Therapeutic options for all the human prion diseases are currently limited to palliation, as there are no agents capable of reliably causing a sustained improvement in clinical course. A large and diverse selection of drugs have been tried with limited success, including antivirals, antifungals, antibiotics, antimalarials, antidepressants, antioxidants, and analgesics.