VLBI phase-referencing monitoring of water vapor masers around the red supergiant, S Per, was conducted over four years. We successfully obtained proper motions and an annual parallax of the masers and determined the distance to S Per of 2.51±0.09 kpc. The proper motion of the star itself was inferred from the maser proper motions, and it was −0.38 and −1.54 mas/yr for right ascension and declination, respectively. Assuming the distance from the sun to the Galactic center, R0, of 8.5 kpc and the rotation velocity around the sun, Θ0, of 220 km/s, the Galactic rotation velocity around S Per is 200 km/s.